NO970803L - Fremgangsmåte for identifisering av forbindelser egnet for behandling av autoimmune sykdommer - Google Patents
Fremgangsmåte for identifisering av forbindelser egnet for behandling av autoimmune sykdommerInfo
- Publication number
- NO970803L NO970803L NO970803A NO970803A NO970803L NO 970803 L NO970803 L NO 970803L NO 970803 A NO970803 A NO 970803A NO 970803 A NO970803 A NO 970803A NO 970803 L NO970803 L NO 970803L
- Authority
- NO
- Norway
- Prior art keywords
- ciita
- methods
- identifying compounds
- treatment
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- 101100382122 Homo sapiens CIITA gene Proteins 0.000 abstract 3
- 102100026371 MHC class II transactivator Human genes 0.000 abstract 3
- 108700002010 MHC class II transactivator Proteins 0.000 abstract 3
- 230000004913 activation Effects 0.000 abstract 2
- 230000003993 interaction Effects 0.000 abstract 2
- 102000043131 MHC class II family Human genes 0.000 abstract 1
- 108091054438 MHC class II family Proteins 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Beskrevet er fremgangsmåter for å identifisere forbindelser som hemmer transkripsjonaktivering av CIITA og på denne måte heminer MHC klasse Il-genekspresjon. Slike forbindelser kan affisere induksjon av en itnmunrespons. Fremgangsmåtene benytter uavhengig aktiverings- og interaksjonsdomenene i CIITA. Fremgangs- måtene benytter også aktiverings- og interaks j onsdomene"ne av isotype-spesifikke CIITA-proteiner, noe som tillater identifikasjon av forbindelser som er isotype-spesif ikke inhibitorer av transkripsjon og som er hensiktsmessige for selektivt å affisere immunsystemet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/295,502 US5672473A (en) | 1994-08-24 | 1994-08-24 | Methods of identifying compounds useful for treating autoimmune diseases |
PCT/US1995/010691 WO1996006107A1 (en) | 1994-08-24 | 1995-08-22 | Methods of identifying compounds useful for treating autoimmune diseases |
Publications (2)
Publication Number | Publication Date |
---|---|
NO970803D0 NO970803D0 (no) | 1997-02-21 |
NO970803L true NO970803L (no) | 1997-04-21 |
Family
ID=23137979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO970803A NO970803L (no) | 1994-08-24 | 1997-02-21 | Fremgangsmåte for identifisering av forbindelser egnet for behandling av autoimmune sykdommer |
Country Status (18)
Country | Link |
---|---|
US (1) | US5672473A (no) |
EP (1) | EP0777677B1 (no) |
JP (1) | JPH10507908A (no) |
KR (1) | KR970705573A (no) |
AT (1) | ATE219099T1 (no) |
AU (1) | AU700235B2 (no) |
CA (1) | CA2197233C (no) |
DE (1) | DE69527073T2 (no) |
ES (1) | ES2178677T3 (no) |
FI (1) | FI970735A (no) |
MX (1) | MX9701295A (no) |
NO (1) | NO970803L (no) |
NZ (1) | NZ292369A (no) |
PL (1) | PL318812A1 (no) |
PT (1) | PT777677E (no) |
RU (1) | RU2160447C2 (no) |
WO (1) | WO1996006107A1 (no) |
ZA (1) | ZA957120B (no) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020155542A1 (en) * | 1994-08-26 | 2002-10-24 | Mach Bernard F. | Inhibitors for suppressing the activity of proteins displaying CIITA activity, methods for their identification and pharmaceutical compositions |
US5994082A (en) * | 1994-08-26 | 1999-11-30 | Mach; Bernard | Methods for the identification of inhibitors which suppress the activity of proteins displaying CIITA activity |
AU5795498A (en) * | 1996-12-11 | 1998-07-03 | University Of North Carolina At Chapel Hill, The | Novel forms of class ii mhc transactivator (ciita) |
US6426411B1 (en) * | 1997-05-30 | 2002-07-30 | Dana-Farber Cancer Institute | PGC-1, a novel brown fat pparγ coactivator |
US6410261B2 (en) * | 1997-11-06 | 2002-06-25 | President And Fellows Of Harvard College | CIITA-interacting proteins and methods of use therefor |
FR2775003A1 (fr) | 1998-02-19 | 1999-08-20 | Transgene Sa | Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1 |
AU4219899A (en) | 1998-05-28 | 1999-12-13 | President And Fellows Of Harvard College | Methods and compositions relating to modulation of cartilage cell growth and/or differentiation by modulation of nfatp activity |
US20050244849A1 (en) * | 2000-12-15 | 2005-11-03 | Genetics Institute, Llc | Screening assays for rheumatoid arthritis |
US20030125273A1 (en) * | 2001-12-05 | 2003-07-03 | Isis Pharmaceuticals Inc, | Antisense modulation of MHC class II transactivator expression |
WO2005049860A2 (en) * | 2003-11-05 | 2005-06-02 | Karolinska Innovations Ab | Diagnostic and therapeutic methods and assays |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69429608T2 (de) * | 1993-08-26 | 2002-09-12 | Novimmune Sa, Genf/Geneve | MHC-Klasse-II Transaktivator (CIITA) und dessen Anwendungen |
-
1994
- 1994-08-24 US US08/295,502 patent/US5672473A/en not_active Expired - Lifetime
-
1995
- 1995-08-22 WO PCT/US1995/010691 patent/WO1996006107A1/en not_active Application Discontinuation
- 1995-08-22 KR KR1019970701167A patent/KR970705573A/ko not_active Application Discontinuation
- 1995-08-22 EP EP95930911A patent/EP0777677B1/en not_active Expired - Lifetime
- 1995-08-22 MX MX9701295A patent/MX9701295A/es unknown
- 1995-08-22 ES ES95930911T patent/ES2178677T3/es not_active Expired - Lifetime
- 1995-08-22 AT AT95930911T patent/ATE219099T1/de not_active IP Right Cessation
- 1995-08-22 JP JP8508279A patent/JPH10507908A/ja active Pending
- 1995-08-22 RU RU97104477/14A patent/RU2160447C2/ru active
- 1995-08-22 DE DE69527073T patent/DE69527073T2/de not_active Expired - Fee Related
- 1995-08-22 NZ NZ292369A patent/NZ292369A/xx unknown
- 1995-08-22 CA CA002197233A patent/CA2197233C/en not_active Expired - Fee Related
- 1995-08-22 AU AU34126/95A patent/AU700235B2/en not_active Ceased
- 1995-08-22 PL PL95318812A patent/PL318812A1/xx unknown
- 1995-08-22 PT PT95930911T patent/PT777677E/pt unknown
- 1995-08-24 ZA ZA957120A patent/ZA957120B/xx unknown
-
1997
- 1997-02-21 FI FI970735A patent/FI970735A/fi unknown
- 1997-02-21 NO NO970803A patent/NO970803L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MX9701295A (es) | 1997-05-31 |
KR970705573A (ko) | 1997-10-09 |
PT777677E (pt) | 2002-11-29 |
NZ292369A (en) | 1999-01-28 |
EP0777677A1 (en) | 1997-06-11 |
CA2197233C (en) | 2001-02-20 |
DE69527073D1 (de) | 2002-07-18 |
US5672473A (en) | 1997-09-30 |
AU700235B2 (en) | 1998-12-24 |
ATE219099T1 (de) | 2002-06-15 |
EP0777677A4 (en) | 1998-04-01 |
FI970735A (fi) | 1997-04-21 |
AU3412695A (en) | 1996-03-14 |
DE69527073T2 (de) | 2003-01-23 |
RU2160447C2 (ru) | 2000-12-10 |
ES2178677T3 (es) | 2003-01-01 |
FI970735A0 (fi) | 1997-02-21 |
EP0777677B1 (en) | 2002-06-12 |
CA2197233A1 (en) | 1996-02-29 |
PL318812A1 (en) | 1997-07-07 |
JPH10507908A (ja) | 1998-08-04 |
ZA957120B (en) | 1996-03-26 |
NO970803D0 (no) | 1997-02-21 |
WO1996006107A1 (en) | 1996-02-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |