NO970140L - Technetium-sulfonamide complexes, their use, pharmaceuticals containing them, and process for the preparation of the complexes and agents - Google Patents

Technetium-sulfonamide complexes, their use, pharmaceuticals containing them, and process for the preparation of the complexes and agents

Info

Publication number
NO970140L
NO970140L NO970140A NO970140A NO970140L NO 970140 L NO970140 L NO 970140L NO 970140 A NO970140 A NO 970140A NO 970140 A NO970140 A NO 970140A NO 970140 L NO970140 L NO 970140L
Authority
NO
Norway
Prior art keywords
complexes
agents
technetium
sulfonamide
preparation
Prior art date
Application number
NO970140A
Other languages
Norwegian (no)
Other versions
NO970140D0 (en
Inventor
Johannes Platzek
Bernd Raduechel
Wolfgang Kramp
Ludger Dinkelborg
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO970140D0 publication Critical patent/NO970140D0/en
Publication of NO970140L publication Critical patent/NO970140L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
    • C07C331/16—Isothiocyanates
    • C07C331/28—Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Chelatdannende midler inneholdende sulfonamidgrupper og deres metall- chelater med generell formel I V-CHJ¿-v' ¿^^ NX X N-. 1 <=«.l S i ¦ 3 R (I) hvori n, m, p, V^ vS V^ v*, x\ X^ x', R^ Vi}, v? og R* har forskjellige betyd- ninger, farmasøytiske midler innehold- ende disse forbindelser, deres anvend- elser ved radiodiagnostikk og -terapi, fremgangsmåter for fremstilling av disse forbindelser og midler, så vel som konjugater av disse forbindelser med stoffer som selektivt anrikes i sykt vev, spesielt peptider.Chelating agents containing sulphonamide groups and their metal chelates of general formula I V-CHJ¿-v '¿^^ NX X N-. 1 <= «. L S i ¦ 3 R (I) wherein n, m, p, V ^ vS V ^ v *, x \ X ^ x ', R ^ Vi}, v? and R * has various meanings, pharmaceutical agents containing these compounds, their applications in radiodiagnostics and therapy, methods of preparing these compounds and agents, as well as conjugates of these compounds with substances selectively enriched in disease. tissue, especially peptides.

NO970140A 1994-07-14 1997-01-13 Technetium-sulfonamide complexes, their use, pharmaceuticals containing them, and process for the preparation of the complexes and agents NO970140L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4425781A DE4425781A1 (en) 1994-07-14 1994-07-14 Technetium sulfonamide complexes, their use, pharmaceutical compositions containing them, and processes for the preparation of the complexes and compositions
PCT/EP1995/002404 WO1996002500A1 (en) 1994-07-14 1995-06-22 Technetium-sulphonamide complexes, their use, pharmaceutical agents containing them, and process for producing the complexes and agents

Publications (2)

Publication Number Publication Date
NO970140D0 NO970140D0 (en) 1997-01-13
NO970140L true NO970140L (en) 1997-03-13

Family

ID=6523740

Family Applications (1)

Application Number Title Priority Date Filing Date
NO970140A NO970140L (en) 1994-07-14 1997-01-13 Technetium-sulfonamide complexes, their use, pharmaceuticals containing them, and process for the preparation of the complexes and agents

Country Status (11)

Country Link
EP (1) EP0770063A1 (en)
JP (1) JPH10502648A (en)
KR (1) KR970704682A (en)
CN (1) CN1152914A (en)
AU (1) AU698824B2 (en)
CA (1) CA2194561A1 (en)
DE (1) DE4425781A1 (en)
HU (1) HUT76806A (en)
NO (1) NO970140L (en)
WO (1) WO1996002500A1 (en)
ZA (1) ZA955896B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5028422A (en) * 1986-05-27 1991-07-02 Schering Corporation Treatment of basal cell carcinoma intralesionally with recombinant human alpha interferon
US6586467B2 (en) * 2000-07-06 2003-07-01 Array Biopharma Inc. Preparation of phosphatase inhibitors
KR100445971B1 (en) * 2002-04-15 2004-08-25 한국원자력연구소 Process for labeling technetium or rhenium using borohydride exchange resin
ATE448799T1 (en) * 2002-05-06 2009-12-15 Endocyte Inc FOLATE RECEPTOR TARGETED IMAGING CONJUGATES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4980147A (en) * 1984-06-25 1990-12-25 University Of Utah Research Foundation Radiolabeled technetium chelates for use in renal function determinations
ATE52516T1 (en) * 1986-05-28 1990-05-15 Mallinckrodt Inc TECHNETIUM CHELATE FOR DETERMINING KIDNEY FUNCTION.

Also Published As

Publication number Publication date
ZA955896B (en) 1996-02-19
CA2194561A1 (en) 1996-02-01
KR970704682A (en) 1997-09-06
AU698824B2 (en) 1998-11-05
WO1996002500A1 (en) 1996-02-01
EP0770063A1 (en) 1997-05-02
HUT76806A (en) 1997-11-28
JPH10502648A (en) 1998-03-10
NO970140D0 (en) 1997-01-13
CN1152914A (en) 1997-06-25
DE4425781A1 (en) 1996-01-18
AU2886595A (en) 1996-02-16

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