NO964566L - Binding av E-selektin, P-selektin eller L-selektin til sialyl-Lewisx eller sialyl-Lewisa - Google Patents

Binding av E-selektin, P-selektin eller L-selektin til sialyl-Lewisx eller sialyl-Lewisa

Info

Publication number
NO964566L
NO964566L NO964566A NO964566A NO964566L NO 964566 L NO964566 L NO 964566L NO 964566 A NO964566 A NO 964566A NO 964566 A NO964566 A NO 964566A NO 964566 L NO964566 L NO 964566L
Authority
NO
Norway
Prior art keywords
alkyl
selectin
sialyl
group
mco2h
Prior art date
Application number
NO964566A
Other languages
English (en)
Other versions
NO964566D0 (no
Inventor
Timothy P Kogan
Brian Dupre
Ian L Scott
Karin Keller
Huong Dao
Pamela J Beck
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Publication of NO964566D0 publication Critical patent/NO964566D0/no
Publication of NO964566L publication Critical patent/NO964566L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Forbindelser med generell struktur ! (ii) (CH2)pRs .OH (ii) som inhiberer bindingen av E-selektin og/eller P-selektin til sialyl-Lewisx eller sialyl-Lewisa til stede på en celleoverflate. Fremgangsmåter for inhibering av bindingen av E-selektin og/eller P-selektin til sialyl-Lewisx eller sialyl-Lewisa til stede på en celleoverflate ved anvendelse av disse ', forbindelser, og farmasøytisk aktive preparater omfattende forbindelser som inhiberer bindingen av E-selektin til sialyl-Lewisx er også beskrevet. Anven- deise av forbindelsene ved behandling av septisk sjokk, ARDS, Crohns sykdom, kronisk inflammatorisk sykdom, som psoriasis og reumatoid artritt, og reperfusjonsskader som forekommer etter hjerteattakk, slag og organtransplanta- sjoner, er også beskrevet.
NO964566A 1994-04-29 1996-10-28 Binding av E-selektin, P-selektin eller L-selektin til sialyl-Lewisx eller sialyl-Lewisa NO964566L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/235,293 US5444050A (en) 1994-04-29 1994-04-29 Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
PCT/US1995/005463 WO1995029682A1 (en) 1994-04-29 1995-04-28 BINDING OF E-SELECTIN, P-SELECTIN OR L-SELECTIN TO SIALYL-LEWISx OR SIALYL-LEWIS?a¿

Publications (2)

Publication Number Publication Date
NO964566D0 NO964566D0 (no) 1996-10-28
NO964566L true NO964566L (no) 1996-12-30

Family

ID=22884899

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964566A NO964566L (no) 1994-04-29 1996-10-28 Binding av E-selektin, P-selektin eller L-selektin til sialyl-Lewisx eller sialyl-Lewisa

Country Status (13)

Country Link
US (1) US5444050A (no)
EP (1) EP0758243B1 (no)
JP (1) JPH09512560A (no)
CN (1) CN1151117A (no)
AT (1) ATE234102T1 (no)
AU (1) AU691920B2 (no)
BR (1) BR9507561A (no)
CA (1) CA2189013A1 (no)
CZ (1) CZ314396A3 (no)
DE (1) DE69529892T2 (no)
NO (1) NO964566L (no)
PL (1) PL316994A1 (no)
WO (1) WO1995029682A1 (no)

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CA2546784A1 (en) * 2003-11-19 2005-06-16 Glycomimetics, Inc. Glycomimetic antagonists for both e- and p-selectins
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
WO2006127906A1 (en) * 2005-05-25 2006-11-30 Glycomimetics, Inc. Heterobifunctional compounds for selectin inhibition
CN101291946B (zh) * 2005-08-09 2011-06-29 糖模拟物有限公司 对来自假单胞菌的pa-il凝集素、pa-iil凝集素或其两者的糖模拟物抑制剂
LT2264043T (lt) * 2005-09-02 2017-12-11 Glycomimetics, Inc. Heterobifunkciniai pan-selektino inhibitoriai
EP1764096A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
EP1764095A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
US20090176717A1 (en) * 2006-06-01 2009-07-09 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
EP2074132B1 (en) 2006-10-12 2013-05-15 GlycoMimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
NZ598863A (en) * 2007-02-09 2013-11-29 Glycomimetics Inc Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) * 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
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Also Published As

Publication number Publication date
AU2432995A (en) 1995-11-29
US5444050A (en) 1995-08-22
DE69529892T2 (de) 2004-02-05
CZ314396A3 (en) 1997-05-14
EP0758243A1 (en) 1997-02-19
EP0758243B1 (en) 2003-03-12
CN1151117A (zh) 1997-06-04
DE69529892D1 (de) 2003-04-17
PL316994A1 (en) 1997-03-03
WO1995029682A1 (en) 1995-11-09
EP0758243A4 (en) 1997-08-20
CA2189013A1 (en) 1995-11-09
JPH09512560A (ja) 1997-12-16
NO964566D0 (no) 1996-10-28
ATE234102T1 (de) 2003-03-15
AU691920B2 (en) 1998-05-28
BR9507561A (pt) 1997-08-05

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