NO962186L - Fremgangsmåte for fremstilling av kombinatoriske forbindelsesbiblioteker - Google Patents

Fremgangsmåte for fremstilling av kombinatoriske forbindelsesbiblioteker

Info

Publication number
NO962186L
NO962186L NO962186A NO962186A NO962186L NO 962186 L NO962186 L NO 962186L NO 962186 A NO962186 A NO 962186A NO 962186 A NO962186 A NO 962186A NO 962186 L NO962186 L NO 962186L
Authority
NO
Norway
Prior art keywords
preparing combinatorial
combinatorial connection
connections
connection libraries
libraries
Prior art date
Application number
NO962186A
Other languages
English (en)
Other versions
NO962186D0 (no
Inventor
Eduard Felder
Hans Rink
Ian Timothy William Matthews
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of NO962186D0 publication Critical patent/NO962186D0/no
Publication of NO962186L publication Critical patent/NO962186L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/0054—Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572—Chemical means
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Diabetes (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det blir beskrevet en fremgangsmåte for fremstilling av et flertall forskjellige enheter bestående av en fast eller halvfast bærer (perler), en syntetisk oligomer (ligand) og en identifikasjonsstruktur (merke), ved hjelp av hvilke monomerene i ligandene er kodet, og anvendelse av nevnte bibliotek for søk etter nye klasser av forbindelser og individu- elle forbindelser. Oppfinnelsen angår videre forbindelser runnet med den nye prosessen og anvendelsen derav som trombinhemmere.
NO962186A 1993-12-09 1996-05-29 Fremgangsmåte for fremstilling av kombinatoriske forbindelsesbiblioteker NO962186L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93810864 1993-12-09
PCT/EP1994/003936 WO1995016209A1 (en) 1993-12-09 1994-11-28 Process for the production of combinatorial compound libraries

Publications (2)

Publication Number Publication Date
NO962186D0 NO962186D0 (no) 1996-05-29
NO962186L true NO962186L (no) 1996-05-29

Family

ID=8215084

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962186A NO962186L (no) 1993-12-09 1996-05-29 Fremgangsmåte for fremstilling av kombinatoriske forbindelsesbiblioteker

Country Status (9)

Country Link
EP (1) EP0733213A1 (no)
JP (1) JPH09508355A (no)
AU (1) AU1068295A (no)
CA (1) CA2175078A1 (no)
FI (1) FI962371A0 (no)
HU (1) HUT75223A (no)
IL (1) IL111906A0 (no)
NO (1) NO962186L (no)
WO (1) WO1995016209A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5110096A (en) * 1995-03-28 1996-10-16 Novartis Ag Process for the production of combinatorial compound libraries
US6495314B1 (en) * 1995-09-29 2002-12-17 The Scripps Research Institute Process for characterizing proteins
ATE240347T1 (de) * 1995-12-18 2003-05-15 Praecis Pharm Inc Verfahren zum nachweis von verbindungen die bestimmte zielmoleküle binden
US5866341A (en) * 1996-04-03 1999-02-02 Chugai Pharmaceutical Co., Ltd. Compositions and methods for screening drug libraries
ATE338120T2 (de) 1998-11-27 2006-09-15 Ucb Sa Zusammensetzungen und verfahren zur erhöhung der knochenmineralisierung
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
EP1071958A1 (en) * 1999-02-17 2001-01-31 Arcaris, Inc. Methods for substrate-ligand interaction screening
ES2265917T3 (es) * 1999-03-23 2007-03-01 Biovation Limited Aislamiento y analisis de proteinas.
WO2000066259A1 (en) 1999-05-05 2000-11-09 Ut-Battelle, Llc Method and apparatus for combinatorial chemistry
US7351540B1 (en) 2000-03-17 2008-04-01 Merck Patent Gmbh Protein isolation and analysis
AU2001259586A1 (en) * 2000-05-05 2001-11-20 Agilix Corporation Highly multiplexed reporter carrier systems
DE10117274B4 (de) * 2001-04-06 2005-03-03 Hte Ag The High Throughput Experimentation Company Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek
WO2002090600A2 (en) 2001-05-08 2002-11-14 Darwin Molecular Corporation A method for regulating immune function in primates using the foxp3 protein
AU2002365271B2 (en) * 2001-11-06 2008-12-11 Agilix Corporation Sensitive coded detection systems
WO2004048552A2 (en) 2002-11-21 2004-06-10 Celltech R & D, Inc. Modulating immune responses
AU2005227785A1 (en) 2004-03-31 2005-10-13 Takayuki Doi Labeling substance and chimera substance, process for preparing these substances, and method of biosubstance trapping, structural analysis or/and identification with use of the labeling substance
CA3217862A1 (en) 2021-05-05 2022-11-10 Radius Pharmaceuticals, Inc. Animal model having homologous recombination of mouse pth1 receptor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02104595A (ja) * 1988-03-04 1990-04-17 Univ Alabama 非ペプチドのペプチド相当物及びそのデザイン方法
US5650489A (en) * 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
EP0570428B1 (en) * 1991-02-04 1998-12-16 Akzo Nobel N.V. FACTOR IIa INHIBITORS
CA2118806A1 (en) * 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers

Also Published As

Publication number Publication date
WO1995016209A1 (en) 1995-06-15
EP0733213A1 (en) 1996-09-25
IL111906A0 (en) 1995-03-15
JPH09508355A (ja) 1997-08-26
NO962186D0 (no) 1996-05-29
FI962371A (fi) 1996-06-07
AU1068295A (en) 1995-06-27
HUT75223A (en) 1997-04-28
HU9601588D0 (en) 1996-08-28
FI962371A0 (fi) 1996-06-07
CA2175078A1 (en) 1995-06-15

Similar Documents

Publication Publication Date Title
NO962186L (no) Fremgangsmåte for fremstilling av kombinatoriske forbindelsesbiblioteker
MY102884A (en) Improved method for determining mimotopes.
ATE234268T1 (de) Synthese von n-substituierten oligomeren
ATE217972T1 (de) Synthese kombinatorischer bibliotheken
DE69634191D1 (de) Kombinatorische bibliotheken von substrat-gebundenen zyklischen organischen verbindungen
DE69930137D1 (de) Verfahren zum screenen und herstellen von verbindungsbibliotheken
DE69619825D1 (de) Kombinatorische bibliotheken aus markierten biochemischen verbindungen und verfahren zu ihrer herstellung
DE69519225D1 (de) Verfahren zum nachweis von verbindungen einer konbinatorischen bibliothek.
KR100204360B1 (en) A method for identifying a polynucleotide molecule having a selected nucleic acid sequence from a library of random or semi-random polynucleotide molecules
ATE437844T1 (de) Identifizierung von verbindung-protein wechselwirkungen mit bibliotheken von gekoppelten protein-nukleinsäure-molekülen
DE69332524D1 (de) Synthese von N-substituierten Oligomeren
ATE149160T1 (de) Verfahren zu reinigung von taxol derivate
ATE358182T1 (de) Genomteilung
ZA200106630B (en) Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof.
CN1193772A (zh) 可装入硬件支持
WO2000021909A2 (en) Selecting codes to be used for encoding combinatorial libraries
Appell et al. Biological screening of a large combinatorial library
DK1044418T3 (da) Fremgangsmåde til tilvejebringelse, identificering og beskrivelse af molekyler, der er i stand til at udvise en ønsket opførsel, navnlig inden for det farmaceutiske område og molekyler opnået ved denne fremgangsmåde
DE59703469D1 (de) Verfahren zur herstellung von polymerisaten von alkenen durch gasphasenpolymerisation
ATE541264T1 (de) Profil-suche in nuclein-säuresequenzen mit schneller fourier-transformation
WO1997014106A1 (en) Identification of common chemical activity through comparison of substructural fragments
ATE290691T1 (de) Verfahren zur identifizierung von leitstrukturen oder aktiven verbindungen
WO2002081077A3 (en) System for the synthesis of spatially separated libraries of compounds and methods for the use thereof
Dayringer et al. Computer‐aided interpretation of mass spectra. Increased information form characteristic ion
ATE403494T1 (de) Verfahren zur herstellung einer vielzahl von bausteinen einer materialbibliothek