NO962000L - Prolegemidler av en inhibitor av HIV-protease - Google Patents

Prolegemidler av en inhibitor av HIV-protease

Info

Publication number
NO962000L
NO962000L NO962000A NO962000A NO962000L NO 962000 L NO962000 L NO 962000L NO 962000 A NO962000 A NO 962000A NO 962000 A NO962000 A NO 962000A NO 962000 L NO962000 L NO 962000L
Authority
NO
Norway
Prior art keywords
hiv protease
promoters
protease inhibitor
hiv
treating
Prior art date
Application number
NO962000A
Other languages
English (en)
Other versions
NO962000D0 (no
Inventor
Jose Alexander
Dilbir Bindra
Bruce D Dorsey
Arnold J Repta
Joseph P Vacca
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO962000D0 publication Critical patent/NO962000D0/no
Publication of NO962000L publication Critical patent/NO962000L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Prolegemidler med formel (I) er anvendbare ved inhibering av HIV-protease, forhindring eller behandling av infeksjon med HIV og behandling av AIDS, enten som forbindelser, farmasøytisk akseptable salter, farmasøytiske preparatbestanddeler, enten eller ikke i kombinasjon med andre antivirale midler, immuno- modulatorer, antibiotika eller vaksiner. Metoder for behandling av AIDS og metoder for forhindring eller behandling av infeksjon med HIV er også beskrevet.
NO962000A 1993-11-18 1996-05-15 Prolegemidler av en inhibitor av HIV-protease NO962000L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15420493A 1993-11-18 1993-11-18
PCT/US1994/013085 WO1995014016A1 (en) 1993-11-18 1994-11-14 Prodrugs of an inhibitor of hiv protease

Publications (2)

Publication Number Publication Date
NO962000D0 NO962000D0 (no) 1996-05-15
NO962000L true NO962000L (no) 1996-05-15

Family

ID=22550424

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962000A NO962000L (no) 1993-11-18 1996-05-15 Prolegemidler av en inhibitor av HIV-protease

Country Status (17)

Country Link
US (1) US5733907A (no)
EP (1) EP0729467A1 (no)
JP (1) JPH09505303A (no)
KR (1) KR960705809A (no)
CN (1) CN1139432A (no)
AU (1) AU687128B2 (no)
CA (1) CA2174649A1 (no)
CZ (1) CZ140696A3 (no)
FI (1) FI962073L (no)
HU (1) HUT76270A (no)
IL (1) IL111584A0 (no)
NO (1) NO962000L (no)
NZ (1) NZ276622A (no)
PL (1) PL314486A1 (no)
SK (1) SK61496A3 (no)
WO (1) WO1995014016A1 (no)
ZA (1) ZA949127B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
MY126358A (en) * 1996-03-22 2006-09-29 Glaxo Group Ltd Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2012199A (en) * 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
FR2773994B1 (fr) * 1998-01-23 2002-10-11 Univ Nice Sophia Antipolis Prodrogues issues d'anti-proteases inhibitrices du virus de l'immunodeficience humaine (vih) pour l'amelioration de leur biodisponibilite, de leur tropisme vers et/ou de leur delivrance dans le systeme nerveux central
DK1086076T3 (da) 1998-06-19 2005-03-29 Vertex Pharma Sulfonamidinhibitorer af aspartylprotease
TNSN00027A1 (fr) 1999-02-12 2005-11-10 Vertex Pharma Inhibiteurs de l'aspartyle protease
EP1272463A1 (en) * 2000-01-28 2003-01-08 Rohm And Haas Company Enhanced propertied pharmaceuticals
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7202092B2 (en) * 2001-07-13 2007-04-10 Roche Diagnostics Operations, Inc. Indinavir derivatives useful in immunoassay
AU2002316231A1 (en) * 2002-02-19 2003-09-29 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
US8603949B2 (en) * 2003-06-17 2013-12-10 California Institute Of Technology Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes
US7662987B2 (en) * 2003-07-15 2010-02-16 Xenoport, Inc. Methods for synthesis of acyloxyalkyl compounds
KR101140559B1 (ko) * 2003-08-20 2012-07-05 제노포트 인코포레이티드 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
DK1716115T3 (da) 2003-12-30 2013-05-27 Xenoport Inc Syntese af acyloxyalkylcarbamat-prodrug og mellemprodukter deraf

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US541168A (en) * 1895-06-18 Frank e
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
JPH03500772A (ja) * 1987-10-21 1991-02-21 ジ・アップジョン・カンパニー （１‐アミノ‐２‐ヒドロキシ‐２‐ヘテロサイクリック）エチル基を含有するレニン抑制物質類
DK24089D0 (da) * 1989-01-20 1989-01-20 Hans Bundgaard Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5169952A (en) * 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides
CA2081970C (en) * 1991-11-08 1997-07-08 Joseph P. Vacca Hiv protease inhibitors useful for the treatment of aids
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
PL179039B1 (pl) * 1993-07-16 2000-07-31 Merck & Co Inc Sposoby wytwarzania zwiazków posrednich dla inhibitorów proteazy HIV oraz nowy zwiazek posredni PL PL PL
US5463067A (en) * 1993-07-16 1995-10-31 Merck & Co., Inc. Process for making HIV protease inhibitors
AU7973994A (en) * 1993-10-13 1995-05-04 Merck & Co., Inc. Combination therapy for hiv infection
US5455351A (en) * 1993-12-13 1995-10-03 Abbott Laboratories Retroviral protease inhibiting piperazine compounds

Also Published As

Publication number Publication date
CN1139432A (zh) 1997-01-01
WO1995014016A1 (en) 1995-05-26
CZ140696A3 (en) 1996-12-11
AU687128B2 (en) 1998-02-19
FI962073A0 (fi) 1996-05-15
HU9601340D0 (en) 1996-07-29
NZ276622A (en) 1997-09-22
IL111584A0 (en) 1995-01-24
HUT76270A (en) 1997-07-28
ZA949127B (en) 1996-05-17
NO962000D0 (no) 1996-05-15
KR960705809A (ko) 1996-11-08
CA2174649A1 (en) 1995-05-26
AU1096095A (en) 1995-06-06
US5733907A (en) 1998-03-31
SK61496A3 (en) 1996-11-06
FI962073A7 (fi) 1996-05-15
JPH09505303A (ja) 1997-05-27
PL314486A1 (en) 1996-09-16
FI962073L (fi) 1996-05-15
EP0729467A1 (en) 1996-09-04

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