NO962000L - Prolegemidler av en inhibitor av HIV-protease - Google Patents

Prolegemidler av en inhibitor av HIV-protease

Info

Publication number
NO962000L
NO962000L NO962000A NO962000A NO962000L NO 962000 L NO962000 L NO 962000L NO 962000 A NO962000 A NO 962000A NO 962000 A NO962000 A NO 962000A NO 962000 L NO962000 L NO 962000L
Authority
NO
Norway
Prior art keywords
hiv protease
promoters
protease inhibitor
hiv
treating
Prior art date
Application number
NO962000A
Other languages
English (en)
Other versions
NO962000D0 (no
Inventor
Jose Alexander
Dilbir Bindra
Bruce D Dorsey
Arnold J Repta
Joseph P Vacca
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO962000L publication Critical patent/NO962000L/no
Publication of NO962000D0 publication Critical patent/NO962000D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Prolegemidler med formel (I) er anvendbare ved inhibering av HIV-protease, forhindring eller behandling av infeksjon med HIV og behandling av AIDS, enten som forbindelser, farmasøytisk akseptable salter, farmasøytiske preparatbestanddeler, enten eller ikke i kombinasjon med andre antivirale midler, immuno- modulatorer, antibiotika eller vaksiner. Metoder for behandling av AIDS og metoder for forhindring eller behandling av infeksjon med HIV er også beskrevet.
NO962000A 1993-11-18 1996-05-15 Prolegemidler av en inhibitor av HIV-protease NO962000D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15420493A 1993-11-18 1993-11-18
PCT/US1994/013085 WO1995014016A1 (en) 1993-11-18 1994-11-14 Prodrugs of an inhibitor of hiv protease

Publications (2)

Publication Number Publication Date
NO962000L true NO962000L (no) 1996-05-15
NO962000D0 NO962000D0 (no) 1996-05-15

Family

ID=22550424

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962000A NO962000D0 (no) 1993-11-18 1996-05-15 Prolegemidler av en inhibitor av HIV-protease

Country Status (17)

Country Link
US (1) US5733907A (no)
EP (1) EP0729467A1 (no)
JP (1) JPH09505303A (no)
KR (1) KR960705809A (no)
CN (1) CN1139432A (no)
AU (1) AU687128B2 (no)
CA (1) CA2174649A1 (no)
CZ (1) CZ140696A3 (no)
FI (1) FI962073A0 (no)
HU (1) HUT76270A (no)
IL (1) IL111584A0 (no)
NO (1) NO962000D0 (no)
NZ (1) NZ276622A (no)
PL (1) PL314486A1 (no)
SK (1) SK61496A3 (no)
WO (1) WO1995014016A1 (no)
ZA (1) ZA949127B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US6878728B1 (en) 1999-06-11 2005-04-12 Vertex Pharmaceutical Incorporated Inhibitors of aspartyl protease
US20040122000A1 (en) 1981-01-07 2004-06-24 Vertex Pharmaceuticals Incorporated. Inhibitors of aspartyl protease
MY126358A (en) * 1996-03-22 2006-09-29 Glaxo Group Ltd Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs
AU2012199A (en) * 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
FR2773994B1 (fr) * 1998-01-23 2002-10-11 Univ Nice Sophia Antipolis Prodrogues issues d'anti-proteases inhibitrices du virus de l'immunodeficience humaine (vih) pour l'amelioration de leur biodisponibilite, de leur tropisme vers et/ou de leur delivrance dans le systeme nerveux central
DK1086076T3 (da) 1998-06-19 2005-03-29 Vertex Pharma Sulfonamidinhibitorer af aspartylprotease
TWI260322B (en) 1999-02-12 2006-08-21 Vertex Pharma Inhibitors of aspartyl protease
WO2001054481A2 (en) * 2000-01-28 2001-08-02 Rohm And Haas Company Enhanced propertied pharmaceuticals
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7202092B2 (en) * 2001-07-13 2007-04-10 Roche Diagnostics Operations, Inc. Indinavir derivatives useful in immunoassay
WO2003077902A1 (en) * 2002-02-19 2003-09-25 Xenoport, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
WO2005017106A2 (en) * 2003-06-17 2005-02-24 California Institute Of Technology Libraries of optimized cytochrome p450 enzymes and the optimized p450 enzymes
US7662987B2 (en) * 2003-07-15 2010-02-16 Xenoport, Inc. Methods for synthesis of acyloxyalkyl compounds
BRPI0413756A (pt) 2003-08-20 2006-10-31 Xenoport Inc composto, métodos para tratar ou evitar espasticidade ou um sintoma de espasticidade, doença de refluxo gastro-esofágico, vìcio em droga, vìcio em ou abuso de álcool, ou vìcio em ou abuso de nicotina, e tosse ou êmese em um paciente, e, composição farmacêutica
CA2551859C (en) 2003-12-30 2011-10-04 Xenoport, Inc. Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US541168A (en) * 1895-06-18 Frank e
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines
US4144346A (en) * 1977-01-31 1979-03-13 Janssen Pharmaceutica N.V. Novel 1-(1,3-dioxolan-2-ylmethyl)-1H-imidazoles
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
FI902006A7 (fi) * 1987-10-21 1990-04-20 Upjohn Co Menetelmä renniini-inhibiittoreiden valmistamiseksi, jotka sisältävät 1-amino-2-hydroksi-2-heterosyklisen etyylitähteen
DK24089D0 (da) * 1989-01-20 1989-01-20 Hans Bundgaard Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups
US5218114A (en) * 1991-04-10 1993-06-08 Merck & Co., Inc. Cholecystokinin antagonists
US5169952A (en) * 1991-07-02 1992-12-08 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral α-amino epoxides
SG52731A1 (en) * 1991-11-08 1998-09-28 Merck & Co Inc Hiv protease inhibitors useful for the treatment of aids
US5413999A (en) * 1991-11-08 1995-05-09 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
SK282616B6 (sk) * 1993-07-16 2002-10-08 Merck & Co., Inc. Spôsob výroby medziproduktov na výrobu inhibítorov HIV-proteázy a príslušné medziprodukty
US5463067A (en) * 1993-07-16 1995-10-31 Merck & Co., Inc. Process for making HIV protease inhibitors
AU7973994A (en) * 1993-10-13 1995-05-04 Merck & Co., Inc. Combination therapy for hiv infection
US5455351A (en) * 1993-12-13 1995-10-03 Abbott Laboratories Retroviral protease inhibiting piperazine compounds

Also Published As

Publication number Publication date
NZ276622A (en) 1997-09-22
JPH09505303A (ja) 1997-05-27
ZA949127B (en) 1996-05-17
CA2174649A1 (en) 1995-05-26
HU9601340D0 (en) 1996-07-29
FI962073A7 (fi) 1996-05-15
KR960705809A (ko) 1996-11-08
SK61496A3 (en) 1996-11-06
WO1995014016A1 (en) 1995-05-26
HUT76270A (en) 1997-07-28
CN1139432A (zh) 1997-01-01
AU687128B2 (en) 1998-02-19
US5733907A (en) 1998-03-31
AU1096095A (en) 1995-06-06
IL111584A0 (en) 1995-01-24
EP0729467A1 (en) 1996-09-04
FI962073L (fi) 1996-05-15
PL314486A1 (en) 1996-09-16
FI962073A0 (fi) 1996-05-15
CZ140696A3 (en) 1996-12-11
NO962000D0 (no) 1996-05-15

Similar Documents

Publication Publication Date Title
NO954427L (no) Hiv-proteaseinhibitorer som er anvendbare for behandling av AIDS
NO962000L (no) Prolegemidler av en inhibitor av HIV-protease
NO953308L (no) Inhibitorer av HIV-reverstranskriptase
WO1998056761A3 (en) Benzimidazole derivatives
HK129093A (en) N-tert-butyl-decahydro-2(3-amino-2-hydroxy-4-phenyl-butyl)isoquinoline-3-carboxamide & asparaginyl derivatives thereof
DE69228106D1 (de) HIV-Protease-Inhibitoren
MD1224B2 (en) Application of nucleoside analogues with 1,3-oxathiolan for treatment of hepatitis B
UA42699C2 (uk) Бензоксазинонові сполуки, спосіб інгібування зворотної транскриптази, попередження або лікування, комбінації та фармацевтичні композиції
AU3475097A (en) Substituted cyclopentane compounds useful as neuraminidase inhibitors
NO953876D0 (no) HIV-proteaseinhibitorer som er anvendbare for behandling av AIDS
HU9201258D0 (en) Process for the production of medical preparations for treating hiv infections and of their active agents
ATE215952T1 (de) Hiv-proteaseinhibitoren
NO933611L (no) Anti-tumor- og anti-psoriatiske midler
NO934720L (no) Nye HIV protease inhibitorer
NO960775L (no) Anvendelse av kinoksaliner i kombinasjon med proteaseinhibitorer som legemiddel for behandling av AIDS og/eller HIV-infeksjoner
CA2100066A1 (en) Michellamines useful as antiviral agents, composition and method of treatment
DK0604186T3 (da) HIV-proteaseinhibitorer, som er egnede til behandling af AIDS
AU614204B2 (en) 16-hydroxymethyl amphotericin b derivatives
NO20002481L (no) Kombinasjonsterapi for behandling av AIDS
DK0859613T3 (da) Anvendelse af flupirtin til forebyggelse og behandling af sygdomme, som er forbundet med beskadigelse af det hæmopoietiske cellesystem
NO965591L (no) Kombinasjonsbehandling av HIV-infeksjon
EP0774969B8 (en) Hiv protease inhibitor combination
NO944208L (no) Nye kinazoliner som inhibitorer av HIV-reverstranskriptase
WO1988008707A3 (en) Rubradirin derivatives for treatment of hiv infection
FI970565A0 (fi) HIV-proteaasia inhiboiva yhdistelmä