NO960341L - Rekombinant C140-reseptor og dens agonister og antagonister - Google Patents
Rekombinant C140-reseptor og dens agonister og antagonisterInfo
- Publication number
- NO960341L NO960341L NO960341A NO960341A NO960341L NO 960341 L NO960341 L NO 960341L NO 960341 A NO960341 A NO 960341A NO 960341 A NO960341 A NO 960341A NO 960341 L NO960341 L NO 960341L
- Authority
- NO
- Norway
- Prior art keywords
- receptor
- antagonists
- availability
- agonists
- recombinant
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title abstract 3
- 102000005962 receptors Human genes 0.000 abstract 4
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 102000006240 membrane receptors Human genes 0.000 abstract 1
- 210000000287 oocyte Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
DNA som koder for C14 0-celleoverflate-reseptoren er blitt klonet og sekvensert. Tilgjengeligheten av dette DNAet tillater rekombinant fremstilling av C140-reseptoren, som kan dannes på celle- eller oocytt-overflater og er anvendelig i testsystemer både for deteksjonen av substanser som påvirker dens aktivitet, omfattende agonister og antagonister. Videre muliggjør avsløringen av strukturen til C14 0-reseptoren utfo-rmning av agonist- og antagonist-forbindelser som er anven-delige i disse testene. Tilgjengeligheten av C140-reseptoren tillater også produksjon av antistoffer som er spesifikt immunoreaktive med reseptoren per se, eller med spesifikke regioner derav.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/097,938 US5629174A (en) | 1993-07-26 | 1993-07-26 | Recombinant C140 receptor |
PCT/US1994/008536 WO1995003318A1 (en) | 1993-07-26 | 1994-07-26 | Recombinant c140 receptor and its agonists and antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
NO960341D0 NO960341D0 (no) | 1996-01-26 |
NO960341L true NO960341L (no) | 1996-03-26 |
Family
ID=22265852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960341A NO960341L (no) | 1993-07-26 | 1996-01-26 | Rekombinant C140-reseptor og dens agonister og antagonister |
Country Status (12)
Country | Link |
---|---|
US (1) | US5629174A (no) |
EP (1) | EP0804452B1 (no) |
JP (1) | JPH09503906A (no) |
KR (1) | KR960703939A (no) |
CN (1) | CN1057118C (no) |
AT (1) | ATE205502T1 (no) |
AU (1) | AU701677B2 (no) |
CA (1) | CA2168232A1 (no) |
DE (1) | DE69428292T2 (no) |
NO (1) | NO960341L (no) |
NZ (1) | NZ271516A (no) |
WO (1) | WO1995003318A1 (no) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6297026B1 (en) * | 1993-07-26 | 2001-10-02 | Cor Therapeutics Inc. | Nucleic acids encoding the C140 receptor |
US20020032314A1 (en) * | 1994-10-28 | 2002-03-14 | Chrysalis Biotechnology, Inc. | Synthetic peptide neutrophil cell chemotactic agents |
US6602978B1 (en) * | 1994-10-28 | 2003-08-05 | Chrysalis Biotechnology | Synthetic peptide neutrophil cell chemotactic agents |
JPH11514207A (ja) * | 1995-01-25 | 1999-12-07 | シーオーアール・セラピューティックス・インコーポレーテッド | 組換えc140リセプター、そのアゴニストおよびアンタゴニスト、並びに該リセプターをコードする核酸 |
US5892014A (en) | 1996-10-30 | 1999-04-06 | The Regents Of The University Of California | DNA encoding a protease-activated receptor 3 |
US6737252B2 (en) | 1997-07-25 | 2004-05-18 | Schering Corporation | 7 transmembrane receptor family member BLRX |
US20030013155A1 (en) * | 1998-08-20 | 2003-01-16 | Millennium Pharmaceuticals, Inc. | 14400 receptor, a novel G-protein coupled receptor |
JP3677421B2 (ja) * | 1999-12-27 | 2005-08-03 | 扶桑薬品工業株式会社 | 涙液分泌促進組成物 |
KR100436441B1 (ko) * | 2001-10-11 | 2004-06-16 | 한국화장품주식회사 | 지속성 립스틱 조성물 |
FR2883873B1 (fr) | 2005-03-31 | 2009-07-10 | Pharmamens Sarl | Inhibiteurs d'age |
US7888482B2 (en) | 2006-02-10 | 2011-02-15 | Amgen Inc. | Antibodies that bind PAR-2 |
AR070911A1 (es) * | 2008-03-19 | 2010-05-12 | Regeneron Pharma | Uso de antagonistas del receptor par2 activado con proteasa |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5019646A (en) * | 1987-08-25 | 1991-05-28 | Regents Of The University Of Minnesota | Polypeptides with fibronectin activity |
US5128254A (en) * | 1989-11-01 | 1992-07-07 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Cdna encoding the long isoform of the d2 dopamine receptor |
AU701822B2 (en) * | 1993-07-26 | 1999-02-04 | Millennium Pharmaceuticals, Inc. | Recombinant C140 receptor, its agonists and antagonists, and nucleic acids encoding the receptor |
-
1993
- 1993-07-26 US US08/097,938 patent/US5629174A/en not_active Expired - Lifetime
-
1994
- 1994-07-26 CA CA002168232A patent/CA2168232A1/en not_active Abandoned
- 1994-07-26 AT AT94925135T patent/ATE205502T1/de not_active IP Right Cessation
- 1994-07-26 CN CN94193502A patent/CN1057118C/zh not_active Expired - Fee Related
- 1994-07-26 WO PCT/US1994/008536 patent/WO1995003318A1/en active IP Right Grant
- 1994-07-26 DE DE69428292T patent/DE69428292T2/de not_active Expired - Fee Related
- 1994-07-26 EP EP94925135A patent/EP0804452B1/en not_active Expired - Lifetime
- 1994-07-26 JP JP7505408A patent/JPH09503906A/ja active Pending
- 1994-07-26 KR KR1019960700414A patent/KR960703939A/ko active IP Right Grant
- 1994-07-26 NZ NZ271516A patent/NZ271516A/en unknown
- 1994-07-26 AU AU75167/94A patent/AU701677B2/en not_active Ceased
-
1996
- 1996-01-26 NO NO960341A patent/NO960341L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CA2168232A1 (en) | 1995-02-02 |
NZ271516A (en) | 1997-01-29 |
EP0804452A1 (en) | 1997-11-05 |
EP0804452B1 (en) | 2001-09-12 |
JPH09503906A (ja) | 1997-04-22 |
KR960703939A (ko) | 1996-08-31 |
EP0804452A4 (en) | 1998-08-12 |
AU701677B2 (en) | 1999-02-04 |
ATE205502T1 (de) | 2001-09-15 |
DE69428292D1 (de) | 2001-10-18 |
US5629174A (en) | 1997-05-13 |
CN1131950A (zh) | 1996-09-25 |
DE69428292T2 (de) | 2002-06-27 |
NO960341D0 (no) | 1996-01-26 |
CN1057118C (zh) | 2000-10-04 |
AU7516794A (en) | 1995-02-20 |
WO1995003318A1 (en) | 1995-02-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1378524A3 (en) | Recombinant thrombin receptor antibodies and their use | |
NO960341L (no) | Rekombinant C140-reseptor og dens agonister og antagonister | |
WO1998010068A3 (en) | Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals | |
GB2286398B (en) | Human metabotropic glutamate receptors,nucleic acids encoding same and uses thereof | |
Yu et al. | Pancreatic receptors for cholecystokinin: evidence for three receptor classes | |
ATE203566T1 (de) | Protein-g-gekoppelte glutaminsäure-rezeptoren | |
DE69334100D1 (de) | Elk ligand, ein cytokin | |
DK0474744T3 (da) | PDGF-alfa-receptor | |
DE69837811D1 (de) | Menschlicher lysophosphatidsäure rezeptor und dessen verwendung | |
CA2279881A1 (en) | A method of identifying modulators of cell surface membrane receptors useful in the treatment of disease | |
Winder et al. | Structural and functional characterization of calponin fragments. | |
Kassis et al. | Desensitization of the mammalian beta-adrenergic receptor: analysis of receptor redistribution on nonlinear sucrose gradients. | |
Kiener et al. | Increased levels of circulating intercellular adhesion molecule-1 in patients with systemic sclerosis. | |
NO973422D0 (no) | Recombinant C140-reseptor, dens agonister og antagonister og nukleinsyrer som koder for reseptoren | |
ATE273390T1 (de) | Säugertier edg-7 rezeptor homologen | |
Kratzsch et al. | Measurement of serum exon 3-retaining growth hormone-binding protein in children and adolescents by radioimmunoassay | |
Johnson et al. | Identification and topography of substrates for protein carboxyl methyltransferase in synaptic membrane and myelin‐enriched fractions of bovine and rat brain | |
Miller et al. | Potassium release by alpha 2-adrenergic receptor stimulation of rat parotid acinar cells. | |
Bymaster et al. | Arachidonic acid release in cell lines transfected with muscarinic receptors: a simple functional assay to determine response of agonists | |
BR9506511A (pt) | Processo e composiçao para prevenir ou reduzir a severidade de psoriase processo para evitar proliferaçao das células e processo para diagnosticar ou predizir a susceptibilidade á psoriase e vetor | |
Lotstra et al. | Possible misinterpretations of radioimmunoassay results of endocrine tissues containing peptides in the micromolar range. | |
Majeed et al. | Serotonergic regulation of the brain and gut beta-endorphin and dynorphin content in the rat. | |
Zhu et al. | Alterations in Activities of Protein Phosphatases PP1 and PP2A in and B Lymphocytes of Autoimmune MRL/MpJ-lpr/lpr Mice | |
DE69131289D1 (de) | Polypeptide mit einer aktivität des menschlichen dopaminergischen rezeptors, deren kodierende nukleinsäuresequenzen und verwendung dieser polypeptide | |
Schlesinger et al. | The nature and function of T-cell antigens. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |