NO960080L - Piperidinyl substituerte metanoantracener som D1/D2 antagonister og 5HT2-serotonin-antagonister - Google Patents
Piperidinyl substituerte metanoantracener som D1/D2 antagonister og 5HT2-serotonin-antagonisterInfo
- Publication number
- NO960080L NO960080L NO960080A NO960080A NO960080L NO 960080 L NO960080 L NO 960080L NO 960080 A NO960080 A NO 960080A NO 960080 A NO960080 A NO 960080A NO 960080 L NO960080 L NO 960080L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- antagonists
- hydrogen
- formula
- independently selected
- Prior art date
Links
- 125000003386 piperidinyl group Chemical group 0.000 title abstract 3
- 239000005557 antagonist Substances 0.000 title 1
- 229940082988 antihypertensives serotonin antagonists Drugs 0.000 title 1
- 239000003420 antiserotonin agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000000164 antipsychotic agent Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003210 dopamine receptor blocking agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 150000003462 sulfoxides Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939314250A GB9314250D0 (en) | 1993-07-09 | 1993-07-09 | Piperidinyl compounds |
| PCT/GB1994/001439 WO1995001974A1 (en) | 1993-07-09 | 1994-07-04 | Piperidinyl substituted methanoanthracenes as d1/d2-antagonists and 5ht2-serotanin-antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO960080D0 NO960080D0 (no) | 1996-01-08 |
| NO960080L true NO960080L (no) | 1996-01-08 |
Family
ID=10738563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960080A NO960080L (no) | 1993-07-09 | 1996-01-08 | Piperidinyl substituerte metanoantracener som D1/D2 antagonister og 5HT2-serotonin-antagonister |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP0707579B1 (cs) |
| JP (1) | JP3031634B2 (cs) |
| AP (1) | AP521A (cs) |
| AT (1) | ATE175963T1 (cs) |
| AU (1) | AU687414B2 (cs) |
| CA (1) | CA2163994A1 (cs) |
| CZ (1) | CZ4496A3 (cs) |
| DE (1) | DE69416131T2 (cs) |
| DK (1) | DK0707579T3 (cs) |
| DZ (1) | DZ1796A1 (cs) |
| ES (1) | ES2128567T3 (cs) |
| FI (1) | FI960084A7 (cs) |
| GB (2) | GB9314250D0 (cs) |
| HR (1) | HRP940394A2 (cs) |
| HU (1) | HU219239B (cs) |
| IL (1) | IL110222A (cs) |
| MY (1) | MY111604A (cs) |
| NO (1) | NO960080L (cs) |
| NZ (1) | NZ268048A (cs) |
| PL (1) | PL312498A1 (cs) |
| RU (1) | RU2128178C1 (cs) |
| SG (1) | SG45425A1 (cs) |
| SI (1) | SI9400281A (cs) |
| SK (1) | SK2996A3 (cs) |
| WO (1) | WO1995001974A1 (cs) |
| ZA (1) | ZA944930B (cs) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9117639D0 (en) * | 1991-08-15 | 1991-10-02 | Ici Plc | Therapeutic compounds |
-
1993
- 1993-07-09 GB GB939314250A patent/GB9314250D0/en active Pending
-
1994
- 1994-06-30 AP APAP/P/1994/000652A patent/AP521A/en active
- 1994-07-01 GB GB9413235A patent/GB9413235D0/en active Pending
- 1994-07-04 HU HU9503554A patent/HU219239B/hu not_active IP Right Cessation
- 1994-07-04 CA CA002163994A patent/CA2163994A1/en not_active Abandoned
- 1994-07-04 DE DE69416131T patent/DE69416131T2/de not_active Expired - Lifetime
- 1994-07-04 JP JP7503893A patent/JP3031634B2/ja not_active Expired - Fee Related
- 1994-07-04 RU RU96102585A patent/RU2128178C1/ru active
- 1994-07-04 ES ES94919752T patent/ES2128567T3/es not_active Expired - Lifetime
- 1994-07-04 CZ CZ9644A patent/CZ4496A3/cs unknown
- 1994-07-04 EP EP94919752A patent/EP0707579B1/en not_active Expired - Lifetime
- 1994-07-04 PL PL94312498A patent/PL312498A1/xx unknown
- 1994-07-04 SG SG1996007272A patent/SG45425A1/en unknown
- 1994-07-04 AU AU70779/94A patent/AU687414B2/en not_active Ceased
- 1994-07-04 DK DK94919752T patent/DK0707579T3/da active
- 1994-07-04 NZ NZ268048A patent/NZ268048A/en unknown
- 1994-07-04 WO PCT/GB1994/001439 patent/WO1995001974A1/en not_active Ceased
- 1994-07-04 SK SK29-96A patent/SK2996A3/sk unknown
- 1994-07-04 AT AT94919752T patent/ATE175963T1/de not_active IP Right Cessation
- 1994-07-05 IL IL11022294A patent/IL110222A/xx not_active IP Right Cessation
- 1994-07-06 HR HR9314250.3A patent/HRP940394A2/xx not_active Application Discontinuation
- 1994-07-07 ZA ZA944930A patent/ZA944930B/xx unknown
- 1994-07-08 SI SI9400281A patent/SI9400281A/sl unknown
- 1994-07-09 MY MYPI94001799A patent/MY111604A/en unknown
- 1994-07-09 DZ DZ940075A patent/DZ1796A1/fr active
-
1996
- 1996-01-08 FI FI960084A patent/FI960084A7/fi unknown
- 1996-01-08 NO NO960080A patent/NO960080L/no not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |