NO950922L - Beta-laktamer - Google Patents

Beta-laktamer

Info

Publication number
NO950922L
NO950922L NO950922A NO950922A NO950922L NO 950922 L NO950922 L NO 950922L NO 950922 A NO950922 A NO 950922A NO 950922 A NO950922 A NO 950922A NO 950922 L NO950922 L NO 950922L
Authority
NO
Norway
Prior art keywords
cyclo
optionally
substituted
het
alkyl
Prior art date
Application number
NO950922A
Other languages
English (en)
Other versions
NO950922D0 (no
Inventor
Markus Bohringer
Christian Hubschwerlen
Philippe Pflieger
Jean-Luc Specklin
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NO950922D0 publication Critical patent/NO950922D0/no
Publication of NO950922L publication Critical patent/NO950922L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Det beskrives terapeutisk aktive 6-laktamer med den generelle formel I hvor Z er metylen, O eller S og R er H, eventuelt med karboksy, alkoksykarbonyl, karbamoyl, alkylkarbamoyl, fenylkarbamoyl eller hydroksyfenylkarbamoyl substituert (cyklo)alkyl, alkenylmetyl, alkenylmetoksykarbonyl, formyl, eventuelt med halo, cyan, karbamoyl alkoksy, karbamoylalkyltio eller karbamoylalkylamino substituert (cyklo)alkanoyl hhv. (cyklo)alkylsulfonyl, eventuelt med (cyklo)alkyl, alkoksykarbonylalkyl, benzyloksykar- , bonylalkyl eller karboksyalkyl substituert karbamoyl ; eller en ringstruktur med den generelle formel Q-X-CO- (al), Q-X-SO,- (a2), hvor Q er en 5- eller 6-leddet, eventuelt N-, S- og/eller Odig ring og X er en direkte binding eller en av gruppene -CH2-, -CH2CH2-, -CH=CH-, -NH-, -NHCH2-, -CH2NH-, -CH(NH2)-, -CH2CH2NH-, -C(=NOCH3)-, -OCH2- eller -SCH2-, og hvor A er alkyl, hydroksy alkyl, vinyl, cyanvinyl, alkoksy, eventuelt j fenylsubstituert (cyklo)alkanoyloksy hhv. (cyklo)alkyl- sulfonyloksy, eventuelt (cyklo)alkyl-substituert benzo- yloksy hhv. fenylsulfonyloksy, en rest -S-Het eller -S- CH2-Het, hvor Het er en 5- eller 6-leddet, N-, S- og/eller O-holdig heterocyklus, eller en rest CH2-L, hvor L er eventuelt fenylsubstituert (cyklo)- alkanoyloksy hhv. (cyklo)alkylsulfonyloksy, eventuelt (cyklo)alkyl-substituert benzoyloksy hhv. fenyl- sulfonyloksy, karbamoyloksy, (cyklo)alkoksykarbonyl, karboksy, azido, amino, (cyklo)alkanoylaraino, (cyklo)- alkylsulfonylami.no, (cyklo)alkylamino, di-(cyklo)alkyl- amino, en 5- eller 6-leddet, til et N-atom bundet ring eller en rest -S-Het eller -S-CH2-Het, hvor Het har ovennevnte betydning, og farmasøytisk akseptable, lett hydrolyserbare estere og salter av disse forbindelser.
NO950922A 1994-03-11 1995-03-10 Beta-laktamer NO950922L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH75194 1994-03-11
CH26095 1995-01-31

Publications (2)

Publication Number Publication Date
NO950922D0 NO950922D0 (no) 1995-03-10
NO950922L true NO950922L (no) 1995-09-12

Family

ID=25684062

Family Applications (1)

Application Number Title Priority Date Filing Date
NO950922A NO950922L (no) 1994-03-11 1995-03-10 Beta-laktamer

Country Status (14)

Country Link
US (2) US5464617A (no)
EP (1) EP0671401A1 (no)
JP (1) JPH07258254A (no)
KR (1) KR950032198A (no)
CN (1) CN1051547C (no)
AU (1) AU694469B2 (no)
CA (1) CA2143519A1 (no)
CZ (1) CZ62895A3 (no)
FI (1) FI951135A (no)
HU (1) HUT72502A (no)
IL (1) IL112889A (no)
NO (1) NO950922L (no)
NZ (1) NZ270638A (no)
RU (1) RU2143435C1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0508234T3 (da) * 1991-04-11 1996-10-28 Hoffmann La Roche Beta-lactamer
US5712268A (en) * 1991-04-11 1998-01-27 Hoffmann-La Roche Inc. Compositions of tricyclic β-lactams and uses thereof
GB9326248D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Plc Pharmaceutical formulations
TW358097B (en) * 1996-05-24 1999-05-11 Hoffmann La Roche Beta-lactams and their process and pharmaceutical compositions
TR200003807T2 (tr) * 1998-06-22 2001-06-21 Basilea Pharmaceutica Ag Propenil sefalosporin türevleri
CA2341650A1 (en) * 1998-09-01 2000-03-09 Merck & Co., Inc. Carbapenem antibacterial compositions and methods of treatment
US6221859B1 (en) 1999-08-27 2001-04-24 Merck & Co., Inc. Carbapenem antibacterial compositions and methods of the treatment
WO2002022137A1 (en) * 2000-09-12 2002-03-21 Shoichet Brian K β-LACTAM ANALOGS AND USES THEREFOR
CN101249090A (zh) * 2002-11-22 2008-08-27 约翰斯·霍普金斯大学 治疗认知功能障碍的靶位
PL2197881T3 (pl) * 2007-09-17 2013-09-30 Basilea Pharmaceutica Ag Sposób wytwarzania związków pośrednich dla mostkowanych monobaktamów
US20110118462A1 (en) * 2009-11-18 2011-05-19 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory N-heterocyclic substituent-containing antibiotic, preparation and use thereof
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
EP2761296B1 (en) 2011-09-28 2017-08-30 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals
US11352325B2 (en) 2011-09-28 2022-06-07 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
CN107110785A (zh) 2014-10-30 2017-08-29 沃特世科技公司 快速制备标记的葡糖基胺和分析生产所述标记的葡糖基胺的糖基化生物分子的方法
CN111796039B (zh) 2014-11-13 2023-03-17 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
CN104610280B (zh) * 2015-02-12 2017-04-05 浙江东邦药业有限公司 一种头孢噻吩酸的制备方法
EP4234062A3 (en) 2016-06-21 2023-10-25 Waters Technologies Corporation Methods of electrospray ionization of glycans modified with amphipathic, strongly basic moieties
EP3472132A4 (en) 2016-06-21 2020-01-15 Waters Technologies Corporation FLUORESCENCE LABELING OF GLYCANS AND OTHER BIOMOLECULES BY REDUCING AMINATION FOR IMPROVED MASS SPECTROMETRY SIGNALS
CN114839302A (zh) 2016-07-01 2022-08-02 沃特世科技公司 使用分子量截留过滤和过滤器上去糖基化从复杂基质快速制备标记的葡基胺的方法
JOP20190061A1 (ar) * 2016-09-28 2019-03-26 Novartis Ag مثبطات بيتا-لاكتاماز

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4018782A (en) * 1972-04-10 1977-04-19 Queen's University 2,2-Dimethyl-3R-carboxy-6S-acylamido-1-oxa-4-aza-5R-bicyclo[3,2,0]heptan-7-ones
US3950352A (en) * 1972-04-10 1976-04-13 Queen's University 2,2-Dimethyl-3R-carboxy-6S-phenyl(or phenoxy)acetamido-1-oxa-4-aza-5R-bicyclo[3,2,0]heptan-7-one and processes for their production
CA1090806A (en) * 1977-01-10 1980-12-02 Mitsuru Yoshioka Oxazolines
US4140688A (en) * 1978-04-03 1979-02-20 Smithkline Corporation Tricyclic (azeto-isoquinoline) β-lactams
US4525304A (en) * 1982-11-16 1985-06-25 Eli Lilly And Company Process for preparing oxazolinoazetidinones
JPS63152384A (ja) * 1986-07-15 1988-06-24 Takeda Chem Ind Ltd ３環性セファムまたはイソセファム化合物，その製造法および用途
US5055463A (en) * 1989-02-02 1991-10-08 Merck & Co., Inc. Spirocyclic 6-amido carbapenems
DK0508234T3 (da) * 1991-04-11 1996-10-28 Hoffmann La Roche Beta-lactamer
AU3264393A (en) * 1992-01-22 1993-09-01 Smithkline Beecham Plc 2-isocephem and oxacephem derivatives, processes for their preparation, intermediates thereof and use as antibacterial agents

Also Published As

Publication number Publication date
JPH07258254A (ja) 1995-10-09
NO950922D0 (no) 1995-03-10
IL112889A0 (en) 1995-06-29
AU694469B2 (en) 1998-07-23
IL112889A (en) 1999-06-20
KR950032198A (ko) 1995-12-20
HUT72502A (en) 1996-05-28
FI951135A0 (fi) 1995-03-10
RU2143435C1 (ru) 1999-12-27
RU95103424A (ru) 1997-01-10
CA2143519A1 (en) 1995-09-12
CZ62895A3 (en) 1995-12-13
CN1051547C (zh) 2000-04-19
US5464617A (en) 1995-11-07
CN1132752A (zh) 1996-10-09
NZ270638A (en) 1996-07-26
AU1364695A (en) 1995-09-21
FI951135A (fi) 1995-09-12
HU9500665D0 (en) 1995-04-28
EP0671401A1 (de) 1995-09-13
US5494666A (en) 1996-02-27

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