NO944748L - New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparation - Google Patents
New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparationInfo
- Publication number
- NO944748L NO944748L NO944748A NO944748A NO944748L NO 944748 L NO944748 L NO 944748L NO 944748 A NO944748 A NO 944748A NO 944748 A NO944748 A NO 944748A NO 944748 L NO944748 L NO 944748L
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- NO
- Norway
- Prior art keywords
- group
- pharmaceutical compositions
- formula
- compositions containing
- alkyl
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Oppfinnelsen angår nye ebur- nameninderivater av formel (I) NR1 R2 (D hvori R1 og R2 så vel som R3 og R4, uav- hengig av hverandre betegner hydrogen, C2.6-alkylgruppe, C2_6-alkenylgruppe; eller en C3_10-alisyklisk gruppe innbe- fattende l til 3 ringer, og hvor denne sistnevnte gruppe kan være substituert med en Cj.j-alkyl- eller C2_6-alkenyl- gruppe; eller R1 og R2 og/eller R3 og R4 sammen med det tilstøtende nitrogenatom og eventuelt med et ytterligere oksy- gen- eller nitrogenatom, danner en 4- til 6-leddet, mettet eller umettet, syklisk gruppe som kan være substituert med en Cj.j-alkyl- eller C2.6-alkenyl- gruppe; to av X, Y og Z er nitrogen mens den tredje av disse betegner en metingruppe; n er l eller 2; W betegner oksygen eller to hydrogenatomer; og den bølgede linje betegner cc-/a-, a-/p- eller p-/a-sterisk stilling, så vel som deres syreaddisjonssalter og solvater. Oppfinnelsen angår enn videre.farma- søytiske preparater inneholdende de ovenfor angitte forbindelser, så vel som en fremgangsmåte for fremstilling av forbindelsene av formel (I). Forbin- delsene av formel (I) utviser anti- oksiderende effekt, og de kan derfor være anvendbare for inhibering av per- oksidasjon av lipider som forekommer i pattedyr (innbefattende mennesker).The invention relates to novel eburomenenine derivatives of formula (I) NR1 R2 (D wherein R1 and R2 as well as R3 and R4 independently represent hydrogen, C2-6 alkyl group, C2-6 alkenyl group; or a C3-10 alicyclic group comprising 1 to 3 rings, and wherein said latter group may be substituted by a C1-6 alkyl or C2-6 alkenyl group; or R1 and R2 and / or R3 and R4 together with the adjacent nitrogen atom and optionally additional oxygen or nitrogen atom forms a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C1-6 alkyl or C2-6 alkenyl group; two of X, Y and Z is nitrogen while the third of these represents a methane group; n is 1 or 2; W represents oxygen or two hydrogen atoms; and the wavy line represents cc / a, a / p or p / asteric position, The invention further relates to pharmaceutical compositions containing the above-mentioned compounds, e.g. well as a process for preparing compounds of formula (I). The compounds of formula (I) exhibit antioxidant effect and may therefore be useful for inhibiting the peroxidation of lipids present in mammals (including humans).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9201911A HU209678B (en) | 1992-06-09 | 1992-06-09 | Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them |
PCT/HU1993/000036 WO1993025550A1 (en) | 1992-06-09 | 1993-06-08 | Novel biologically active eburnamenine derivatives, pharmaceutical compositions containing them and process for preparing same |
Publications (2)
Publication Number | Publication Date |
---|---|
NO944748D0 NO944748D0 (en) | 1994-12-08 |
NO944748L true NO944748L (en) | 1995-02-08 |
Family
ID=26318089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO944748A NO944748L (en) | 1992-06-09 | 1994-12-08 | New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparation |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO944748L (en) |
-
1994
- 1994-12-08 NO NO944748A patent/NO944748L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO944748D0 (en) | 1994-12-08 |
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