NO944748L - New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparation - Google Patents

New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparation

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Publication number
NO944748L
NO944748L NO944748A NO944748A NO944748L NO 944748 L NO944748 L NO 944748L NO 944748 A NO944748 A NO 944748A NO 944748 A NO944748 A NO 944748A NO 944748 L NO944748 L NO 944748L
Authority
NO
Norway
Prior art keywords
group
pharmaceutical compositions
formula
compositions containing
alkyl
Prior art date
Application number
NO944748A
Other languages
Norwegian (no)
Other versions
NO944748D0 (en
Inventor
Zoltan Tuba
Sandor Maho
Aniko Gere
Pal Vittay
Bela Kiss
Eva Palosi
Laszlo Szporny
Csaba Szantay
Ferenc Soti
Zsuzsa Baloghne Kardos
Maria Incze
Gabor Balogh
Maria Gazdag
Original Assignee
Richter Gedeon Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU9201911A external-priority patent/HU209678B/en
Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet
Publication of NO944748D0 publication Critical patent/NO944748D0/en
Publication of NO944748L publication Critical patent/NO944748L/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Oppfinnelsen angår nye ebur- nameninderivater av formel (I) NR1 R2 (D hvori R1 og R2 så vel som R3 og R4, uav- hengig av hverandre betegner hydrogen, C2.6-alkylgruppe, C2_6-alkenylgruppe; eller en C3_10-alisyklisk gruppe innbe- fattende l til 3 ringer, og hvor denne sistnevnte gruppe kan være substituert med en Cj.j-alkyl- eller C2_6-alkenyl- gruppe; eller R1 og R2 og/eller R3 og R4 sammen med det tilstøtende nitrogenatom og eventuelt med et ytterligere oksy- gen- eller nitrogenatom, danner en 4- til 6-leddet, mettet eller umettet, syklisk gruppe som kan være substituert med en Cj.j-alkyl- eller C2.6-alkenyl- gruppe; to av X, Y og Z er nitrogen mens den tredje av disse betegner en metingruppe; n er l eller 2; W betegner oksygen eller to hydrogenatomer; og den bølgede linje betegner cc-/a-, a-/p- eller p-/a-sterisk stilling, så vel som deres syreaddisjonssalter og solvater. Oppfinnelsen angår enn videre.farma- søytiske preparater inneholdende de ovenfor angitte forbindelser, så vel som en fremgangsmåte for fremstilling av forbindelsene av formel (I). Forbin- delsene av formel (I) utviser anti- oksiderende effekt, og de kan derfor være anvendbare for inhibering av per- oksidasjon av lipider som forekommer i pattedyr (innbefattende mennesker).The invention relates to novel eburomenenine derivatives of formula (I) NR1 R2 (D wherein R1 and R2 as well as R3 and R4 independently represent hydrogen, C2-6 alkyl group, C2-6 alkenyl group; or a C3-10 alicyclic group comprising 1 to 3 rings, and wherein said latter group may be substituted by a C1-6 alkyl or C2-6 alkenyl group; or R1 and R2 and / or R3 and R4 together with the adjacent nitrogen atom and optionally additional oxygen or nitrogen atom forms a 4- to 6-membered, saturated or unsaturated cyclic group which may be substituted by a C1-6 alkyl or C2-6 alkenyl group; two of X, Y and Z is nitrogen while the third of these represents a methane group; n is 1 or 2; W represents oxygen or two hydrogen atoms; and the wavy line represents cc / a, a / p or p / asteric position, The invention further relates to pharmaceutical compositions containing the above-mentioned compounds, e.g. well as a process for preparing compounds of formula (I). The compounds of formula (I) exhibit antioxidant effect and may therefore be useful for inhibiting the peroxidation of lipids present in mammals (including humans).

NO944748A 1992-06-09 1994-12-08 New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparation NO944748L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9201911A HU209678B (en) 1992-06-09 1992-06-09 Process for producing biologically active eburnamenin-14-carbonyl-amino derivatives and pharmaceutical compositions containing them
PCT/HU1993/000036 WO1993025550A1 (en) 1992-06-09 1993-06-08 Novel biologically active eburnamenine derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (2)

Publication Number Publication Date
NO944748D0 NO944748D0 (en) 1994-12-08
NO944748L true NO944748L (en) 1995-02-08

Family

ID=26318089

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944748A NO944748L (en) 1992-06-09 1994-12-08 New biologically active eburnamenine derivatives, pharmaceutical compositions containing them, and processes for their preparation

Country Status (1)

Country Link
NO (1) NO944748L (en)

Also Published As

Publication number Publication date
NO944748D0 (en) 1994-12-08

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