NO943654L - Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer - Google Patents

Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer

Info

Publication number
NO943654L
NO943654L NO943654A NO943654A NO943654L NO 943654 L NO943654 L NO 943654L NO 943654 A NO943654 A NO 943654A NO 943654 A NO943654 A NO 943654A NO 943654 L NO943654 L NO 943654L
Authority
NO
Norway
Prior art keywords
cell regulatory
methods
protein
regulatory factors
cell
Prior art date
Application number
NO943654A
Other languages
English (en)
Other versions
NO943654D0 (no
Inventor
Erkki I Ruoslahti
Michael D Pierschbacher
Jose Cardenas
William Scot Craig
Daniel G Mullen
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Publication of NO943654D0 publication Critical patent/NO943654D0/no
Publication of NO943654L publication Critical patent/NO943654L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725Proteoglycans, e.g. aggreccan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/50Fusion polypeptide containing protease site
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Fremgangsmåte for inhibering av en aktivitet av en celleregulerings- faktor som omfatter å bringe celle- reguleringsfaktoren i kontakt med et renset polypeptid, hvor polypeptidet omfatter et cellereguleringsfaktorbin- dende domene fra et protein. Proteinet karakteriseres ved en leucinrik repeti- sjon på tilnærmet 24 aminosyrer. I en spesifikk utførelse gjelder foreligg- ende oppfinnelse evnen til decorin, et protein på 40.000 dalton som vanligvis bærer en glykosaminoglykankjede, og mer spesifikt aktive deoorinfragmenter eller disses funksjonelle ekvivalenter, til å binde TGFp. Oppfinnelsen tilveie- bringer også en ny cellereguleringsfak- tor kalt MRF. Videre tilveiebringes fremgangsmåter for identifisering, på- visning og rensing av celleregulerings- faktorer og proteiner som binder og påvirker aktiviteten av cellereguler- ings faktorer.
NO943654A 1992-04-03 1994-09-30 Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer NO943654L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86565292A 1992-04-03 1992-04-03
PCT/US1993/003171 WO1993020202A1 (en) 1992-04-03 1993-04-02 Decorin fragments and methods of inhibiting cell regulatory factors

Publications (2)

Publication Number Publication Date
NO943654D0 NO943654D0 (no) 1994-09-30
NO943654L true NO943654L (no) 1994-12-05

Family

ID=25345963

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943654A NO943654L (no) 1992-04-03 1994-09-30 Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer

Country Status (7)

Country Link
EP (1) EP0636175A1 (no)
JP (1) JPH07508403A (no)
AU (1) AU679178B2 (no)
CA (1) CA2132859A1 (no)
FI (1) FI944575A (no)
NO (1) NO943654L (no)
WO (1) WO1993020202A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69418322D1 (de) * 1993-03-01 1999-06-10 Glycan Pharm Inc Analoge für spezifische oligosaccharid-protein-wechselwirkungen und ihre verwendungen
US5567807A (en) * 1994-07-08 1996-10-22 La Jolla Cancer Research Foundation Processes for the purification of human recombinant decorin and the detection of guanidinium ions
WO2005116066A1 (en) * 2004-05-31 2005-12-08 National University Of Singapore Peptides derived from decorin leucine rich repeats and uses thereof
EP1806359B1 (en) * 2005-09-05 2010-03-17 Immatics Biotechnologies GmbH Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
ES2283212B1 (es) * 2006-03-31 2008-08-16 Lipotec S.A. Peptidos sinteticos utiles en el tratamiento de la piel y su uso en composiciones cosmeticas o dermofarmaceuticas.
HU0700024D0 (en) * 2007-01-11 2007-03-28 Mta Szegedi Biolog Koezpont Use of enhancers in biglycan activuty in the preparation of pharmaceutical compositions having utility in cardiac diseases
EP2538221A3 (en) * 2007-11-05 2013-04-24 Nordic Bioscience A/S Biochemical markers for CVD risk assessment
WO2012125626A2 (en) * 2011-03-14 2012-09-20 Catalent Pharma Solutions Llc Decorin compositions and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010727A1 (en) * 1990-01-22 1991-07-25 La Jolla Cancer Research Foundation Inhibitors of cell regulatory factors

Also Published As

Publication number Publication date
AU679178B2 (en) 1997-06-26
EP0636175A1 (en) 1995-02-01
CA2132859A1 (en) 1993-10-14
JPH07508403A (ja) 1995-09-21
NO943654D0 (no) 1994-09-30
FI944575A0 (fi) 1994-09-30
FI944575A (fi) 1994-11-29
WO1993020202A1 (en) 1993-10-14
AU4025793A (en) 1993-11-08

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