NO943654L - Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer - Google Patents

Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer

Info

Publication number
NO943654L
NO943654L NO943654A NO943654A NO943654L NO 943654 L NO943654 L NO 943654L NO 943654 A NO943654 A NO 943654A NO 943654 A NO943654 A NO 943654A NO 943654 L NO943654 L NO 943654L
Authority
NO
Norway
Prior art keywords
cell regulatory
methods
protein
regulatory factors
cell
Prior art date
Application number
NO943654A
Other languages
English (en)
Other versions
NO943654D0 (no
Inventor
Erkki I Ruoslahti
Michael D Pierschbacher
Jose Cardenas
William Scot Craig
Daniel G Mullen
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Publication of NO943654D0 publication Critical patent/NO943654D0/no
Publication of NO943654L publication Critical patent/NO943654L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

Abstract

Fremgangsmåte for inhibering av en aktivitet av en celleregulerings- faktor som omfatter å bringe celle- reguleringsfaktoren i kontakt med et renset polypeptid, hvor polypeptidet omfatter et cellereguleringsfaktorbin- dende domene fra et protein. Proteinet karakteriseres ved en leucinrik repeti- sjon på tilnærmet 24 aminosyrer. I en spesifikk utførelse gjelder foreligg- ende oppfinnelse evnen til decorin, et protein på 40.000 dalton som vanligvis bærer en glykosaminoglykankjede, og mer spesifikt aktive deoorinfragmenter eller disses funksjonelle ekvivalenter, til å binde TGFp. Oppfinnelsen tilveie- bringer også en ny cellereguleringsfak- tor kalt MRF. Videre tilveiebringes fremgangsmåter for identifisering, på- visning og rensing av celleregulerings- faktorer og proteiner som binder og påvirker aktiviteten av cellereguler- ings faktorer.
NO943654A 1992-04-03 1994-09-30 Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer NO943654L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86565292A 1992-04-03 1992-04-03
PCT/US1993/003171 WO1993020202A1 (en) 1992-04-03 1993-04-02 Decorin fragments and methods of inhibiting cell regulatory factors

Publications (2)

Publication Number Publication Date
NO943654D0 NO943654D0 (no) 1994-09-30
NO943654L true NO943654L (no) 1994-12-05

Family

ID=25345963

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943654A NO943654L (no) 1992-04-03 1994-09-30 Decorinfragmenter og fremgangsmåter for inhibering av celleregulerende faktorer

Country Status (7)

Country Link
EP (1) EP0636175A1 (no)
JP (1) JPH07508403A (no)
AU (1) AU679178B2 (no)
CA (1) CA2132859A1 (no)
FI (1) FI944575A (no)
NO (1) NO943654L (no)
WO (1) WO1993020202A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE179712T1 (de) * 1993-03-01 1999-05-15 Glycan Pharm Inc Analoge für spezifische oligosaccharid-protein- wechselwirkungen und ihre verwendungen
US5567807A (en) * 1994-07-08 1996-10-22 La Jolla Cancer Research Foundation Processes for the purification of human recombinant decorin and the detection of guanidinium ions
EP1758931A1 (en) * 2004-05-31 2007-03-07 National University of Singapore Peptides derived from decorin leucine rich repeats and uses thereof
ATE461214T1 (de) * 2005-09-05 2010-04-15 Immatics Biotechnologies Gmbh Tumor-assoziierte peptide, welche an unterschiedliche menschliche leukozytenantigene der klasse ii binden
ES2283212B1 (es) * 2006-03-31 2008-08-16 Lipotec S.A. Peptidos sinteticos utiles en el tratamiento de la piel y su uso en composiciones cosmeticas o dermofarmaceuticas.
HU0700024D0 (en) * 2007-01-11 2007-03-28 Mta Szegedi Biolog Koezpont Use of enhancers in biglycan activuty in the preparation of pharmaceutical compositions having utility in cardiac diseases
EP2538221A3 (en) * 2007-11-05 2013-04-24 Nordic Bioscience A/S Biochemical markers for CVD risk assessment
CN103917655B (zh) * 2011-03-14 2016-05-25 康泰伦特药物解决方案有限责任公司 核心蛋白聚糖组合物及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010727A1 (en) * 1990-01-22 1991-07-25 La Jolla Cancer Research Foundation Inhibitors of cell regulatory factors

Also Published As

Publication number Publication date
AU679178B2 (en) 1997-06-26
FI944575A (fi) 1994-11-29
FI944575A0 (fi) 1994-09-30
AU4025793A (en) 1993-11-08
NO943654D0 (no) 1994-09-30
JPH07508403A (ja) 1995-09-21
CA2132859A1 (en) 1993-10-14
EP0636175A1 (en) 1995-02-01
WO1993020202A1 (en) 1993-10-14

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