NO943654L - Decorin fragments and methods for inhibiting cell regulatory factors - Google Patents

Decorin fragments and methods for inhibiting cell regulatory factors

Info

Publication number
NO943654L
NO943654L NO943654A NO943654A NO943654L NO 943654 L NO943654 L NO 943654L NO 943654 A NO943654 A NO 943654A NO 943654 A NO943654 A NO 943654A NO 943654 L NO943654 L NO 943654L
Authority
NO
Norway
Prior art keywords
cell regulatory
methods
protein
regulatory factors
cell
Prior art date
Application number
NO943654A
Other languages
Norwegian (no)
Other versions
NO943654D0 (en
Inventor
Erkki I Ruoslahti
Michael D Pierschbacher
Jose Cardenas
William Scot Craig
Daniel G Mullen
Original Assignee
Jolla Cancer Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jolla Cancer Res Found filed Critical Jolla Cancer Res Found
Publication of NO943654D0 publication Critical patent/NO943654D0/en
Publication of NO943654L publication Critical patent/NO943654L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73—Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

Abstract

Fremgangsmåte for inhibering av en aktivitet av en celleregulerings- faktor som omfatter å bringe celle- reguleringsfaktoren i kontakt med et renset polypeptid, hvor polypeptidet omfatter et cellereguleringsfaktorbin- dende domene fra et protein. Proteinet karakteriseres ved en leucinrik repeti- sjon på tilnærmet 24 aminosyrer. I en spesifikk utførelse gjelder foreligg- ende oppfinnelse evnen til decorin, et protein på 40.000 dalton som vanligvis bærer en glykosaminoglykankjede, og mer spesifikt aktive deoorinfragmenter eller disses funksjonelle ekvivalenter, til å binde TGFp. Oppfinnelsen tilveie- bringer også en ny cellereguleringsfak- tor kalt MRF. Videre tilveiebringes fremgangsmåter for identifisering, på- visning og rensing av celleregulerings- faktorer og proteiner som binder og påvirker aktiviteten av cellereguler- ings faktorer.A method of inhibiting an activity of a cell regulatory factor comprising contacting the cell regulatory factor with a purified polypeptide, wherein the polypeptide comprises a cell regulatory factor binding domain of a protein. The protein is characterized by a leucine-rich repetition of approximately 24 amino acids. In a specific embodiment, the present invention relates to the ability of decorin, a 40,000 dalton protein that usually carries a glycosaminoglycan chain, and more specifically active deoorin fragments or their functional equivalents, to bind TGFβ. The invention also provides a new cell regulation factor called MRF. Furthermore, methods are provided for identifying, detecting and purifying cell regulatory factors and proteins that bind and affect the activity of cell regulatory factors.

NO943654A 1992-04-03 1994-09-30 Decorin fragments and methods for inhibiting cell regulatory factors NO943654L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86565292A 1992-04-03 1992-04-03
PCT/US1993/003171 WO1993020202A1 (en) 1992-04-03 1993-04-02 Decorin fragments and methods of inhibiting cell regulatory factors

Publications (2)

Publication Number Publication Date
NO943654D0 NO943654D0 (en) 1994-09-30
NO943654L true NO943654L (en) 1994-12-05

Family

ID=25345963

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943654A NO943654L (en) 1992-04-03 1994-09-30 Decorin fragments and methods for inhibiting cell regulatory factors

Country Status (7)

Country Link
EP (1) EP0636175A1 (en)
JP (1) JPH07508403A (en)
AU (1) AU679178B2 (en)
CA (1) CA2132859A1 (en)
FI (1) FI944575A (en)
NO (1) NO943654L (en)
WO (1) WO1993020202A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2157388C (en) * 1993-03-01 1998-12-15 Daniel P. Witt Analogs for specific oligosaccharide-protein interactions and uses thereof
US5567807A (en) * 1994-07-08 1996-10-22 La Jolla Cancer Research Foundation Processes for the purification of human recombinant decorin and the detection of guanidinium ions
JP2008503205A (en) * 2004-05-31 2008-02-07 ナショナル ユニヴァーシティ オブ シンガポール Peptide derived from decorin leucine rich repeat and use thereof
PT1806358E (en) * 2005-09-05 2010-05-28 Immatics Biotechnologies Gmbh Tumor-associated peptides binding promiscuously to human leukocyte antigen (hla) class ii molecules
ES2283212B1 (en) * 2006-03-31 2008-08-16 Lipotec S.A. USEFUL SYNTHETIC PEPTIDES IN THE TREATMENT OF SKIN AND ITS USE IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS.
HU0700024D0 (en) * 2007-01-11 2007-03-28 Mta Szegedi Biolog Koezpont Use of enhancers in biglycan activuty in the preparation of pharmaceutical compositions having utility in cardiac diseases
EP2538223A3 (en) * 2007-11-05 2013-04-24 Nordic Bioscience A/S Biochemical markers for CVD risk assessment
WO2012125626A2 (en) * 2011-03-14 2012-09-20 Catalent Pharma Solutions Llc Decorin compositions and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991010727A1 (en) * 1990-01-22 1991-07-25 La Jolla Cancer Research Foundation Inhibitors of cell regulatory factors

Also Published As

Publication number Publication date
JPH07508403A (en) 1995-09-21
FI944575A (en) 1994-11-29
FI944575A0 (en) 1994-09-30
AU4025793A (en) 1993-11-08
EP0636175A1 (en) 1995-02-01
NO943654D0 (en) 1994-09-30
AU679178B2 (en) 1997-06-26
CA2132859A1 (en) 1993-10-14
WO1993020202A1 (en) 1993-10-14

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