NO943540L - Antivirale peptider - Google Patents

Antivirale peptider

Info

Publication number
NO943540L
NO943540L NO943540A NO943540A NO943540L NO 943540 L NO943540 L NO 943540L NO 943540 A NO943540 A NO 943540A NO 943540 A NO943540 A NO 943540A NO 943540 L NO943540 L NO 943540L
Authority
NO
Norway
Prior art keywords
alkyl
cycloalkyl
aryl
group
heterocyclyl
Prior art date
Application number
NO943540A
Other languages
English (en)
Other versions
NO943540D0 (no
Inventor
Colin William Greengrass
Stephen Derek Albert Street
Peter John Whittle
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929206462A external-priority patent/GB9206462D0/en
Priority claimed from GB939301638A external-priority patent/GB9301638D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of NO943540D0 publication Critical patent/NO943540D0/no
Publication of NO943540L publication Critical patent/NO943540L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelse av formel (I) o R2 R4 HO R3 o og farmasøytisk akseptable salter derav og bioprekursorer for dette, hvor R1 er 0,-C^alkyl, C3-C8-cykloalkyl, aryl, heterocyklyl eller CONR9R10; R2 er C^Cg-alkyl, C3-C8-cykloalkyl-(C1-C4)-alkyl, aryl- (C^-C^-alkyl eller heterocyklyl-^-C^-alkyl; R3 er C^Cg-alkyl, C3-C8-cykloalkyl, Cg-Ca-cykloalkyl-^-C^-alkyl, aryl-^-C^alkyl, aryl-CCg-C^-alkenyl, heterocyklyHC^-C^-alkyl eller heterocyklyl- (Cj-C^-alkenyl; R4 er 0,-Cg-alkyl, C3-C8-cykloalkyl, aryl eller heterocyklyl; hver av R5, R6, R7 og R8 er uavhengig av hverandre H, C1-C6-alkyl eller C3-C8-cykloalkyl, eller R5 og R6 eller R7 og R8 kan bli slått sammen for å danne en 3- til 8-leddet karbocyklisk ring; X er en 4- til 10-leddet mono- eller bicyklisk heterocyklisk gruppe inne- holdende karbonringatomer og ett ringnitrogenatom via hvilket gruppen er bundet til den hosliggende karbonylgruppe; gruppen kan være mettet eller delvis umettet og i tillegg til -(CR7R8)m-Het-substituenten kan den være substituert med opp til fire ytterligere substituenter, uavhengig valgt fra F, C^Cg-alkyl, C3-C8-cykloalkyl, OR11 eller NR9R10; Het er en imidazolyl- eller triazolylgruppe hvorav hver even- tuelt kan være substituert med C1-C6-alkyl, C3-C7-cykloalkyl, NR9R10 eller CONR9R10; hvor hver av R9 og R10 uavhengig av hverandre er H, C^-Ce-alkyl eller C3-C8-cykloalkyl eller R9 og R10 kan bli slått sammen for å danne, med nitrogenet til hvilket de er bundet, en 4- til 8-leddet nitrogeninneholdende heterocyklisk gruppe; R11 er H, C^-Cg-alkyl eller C3-C8-cykloalkyl; n og m er hver uavhengig av hverandre O, 1 eller 2, hvor enhver alkyl- eller cykloalkylgruppe Inkludert l ovenfor nevnte definisjoner eventuelt kan være fullstendig eller delvis substituert med fluor; er inhibitorer for retrovirale proteaser med anvendelighet for behandling og profylakse av humane retrovirale infeksjoner.
NO943540A 1992-03-25 1994-09-23 Antivirale peptider NO943540L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929206462A GB9206462D0 (en) 1992-03-25 1992-03-25 Antiviral peptides
GB939301638A GB9301638D0 (en) 1993-01-27 1993-01-27 Antiviral peptides
PCT/EP1993/000597 WO1993019059A1 (en) 1992-03-25 1993-03-13 Antiviral peptides

Publications (2)

Publication Number Publication Date
NO943540D0 NO943540D0 (no) 1994-09-23
NO943540L true NO943540L (no) 1994-11-21

Family

ID=26300586

Family Applications (1)

Application Number Title Priority Date Filing Date
NO943540A NO943540L (no) 1992-03-25 1994-09-23 Antivirale peptider

Country Status (13)

Country Link
EP (1) EP0632808A1 (no)
JP (1) JPH07501556A (no)
KR (1) KR950700901A (no)
AU (1) AU3748393A (no)
BR (1) BR9306138A (no)
CA (1) CA2131154A1 (no)
CZ (1) CZ229594A3 (no)
FI (1) FI944428A0 (no)
HU (1) HU9402744D0 (no)
NO (1) NO943540L (no)
RU (1) RU94041225A (no)
SK (1) SK114094A3 (no)
WO (1) WO1993019059A1 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2098020C (en) * 1991-01-02 2003-10-21 Daniel Schirlin Anti-viral compounds
DE69425971T2 (de) * 1993-07-08 2001-05-23 Merrell Dow Pharma Analoge von difluoro-staton
KR100308839B1 (ko) * 1993-09-09 2002-10-04 메렐 파마슈티칼스 인크. 디플루오로 스타톤 항바이러스성 유사체
US6114380A (en) * 1995-12-18 2000-09-05 Merrell Pharmaceuticals Inc. Difluoro statone analogs
GB9601680D0 (en) 1996-01-27 1996-03-27 Pfizer Ltd Therapeutic agents
AU745855B2 (en) * 1998-02-02 2002-04-11 Lg Chemical Ltd. Farnesyl transferase inhibitors having a piperidine structure and process for preparation thereof
US6809200B2 (en) 2000-07-28 2004-10-26 Pfizer Inc. Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof
EP1879894A1 (en) 2005-04-14 2008-01-23 F.Hoffmann-La Roche Ag Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL91780A (en) * 1988-10-04 1995-08-31 Abbott Lab History of the amine of the xenon-preventing xanine acid, the process for their preparation and the pharmaceutical preparations containing them
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
WO1990012804A2 (en) * 1989-04-18 1990-11-01 The Upjohn Company Peptides having novel polar n-terminal groups
DE4001236A1 (de) * 1990-01-18 1991-07-25 Bayer Ag Neue peptide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel, insbesondere als arzneimittel gegen retroviren

Also Published As

Publication number Publication date
BR9306138A (pt) 1998-06-23
FI944428A (fi) 1994-09-23
CZ229594A3 (en) 1995-04-12
HU9402744D0 (en) 1994-12-28
WO1993019059A1 (en) 1993-09-30
NO943540D0 (no) 1994-09-23
RU94041225A (ru) 1996-07-20
EP0632808A1 (en) 1995-01-11
FI944428A0 (fi) 1994-09-23
JPH07501556A (ja) 1995-02-16
SK114094A3 (en) 1995-04-12
KR950700901A (ko) 1995-02-20
AU3748393A (en) 1993-10-21
CA2131154A1 (en) 1993-09-30

Similar Documents

Publication Publication Date Title
TW200508232A (en) Bicyclic derivatives, their preparation, pharmaceutical compositions containing them and their use in therapy
DE59308619D1 (de) Germicide wirkstoffkombinationen
NO943540L (no) Antivirale peptider
ES2126573T3 (es) Derivado de pirazol (1,5-a)pirimidina y agente antiinflamatorio que contiene este derivado.
MX9706382A (es) Derivados de benzoilo.
NO305209B1 (no) N-alkyl-2-substituerte ATP-analoger, slike forbindelser til fremstilling av terapeutikum, farmas°ytisk preparat inneholdende slike forbindelser, og deres anvendelse
BG101430A (en) Triazolyl derivatives
MY105494A (en) Triazole antifungal agents.
MY116917A (en) N-[4-(heteroarylmethyl)phenyl]-heteroarylamines
MY101208A (en) Phenyl-piperazine anti-arrhythmia agents.
CA2236677A1 (en) 4-pyrimidinyl- or 4-pyrazinyl-piperazinyl-phenyl-oxazolidinone derivatives, their preparation and their use as anti-bacterial agents
EP0324387A3 (en) Composition for treatment of ischemic disorder in organs
DE69106189T2 (de) Substituierte Benzimidazol- und Indazol-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Herbizide.
NZ503822A (en) 2-halo-6-O-substituted erythromycin derivatives, a process for their preparation and pharmaceuticals thereof, useful for treating bacterial infections
ES8703406A1 (es) Un procedimiento para la preparacion de derivados de acetanilida.
MXPA04000494A (es) Antagonistas del factor liberador de corticotropina hetero-biciclico.
ES482701A1 (es) Procedimiento para la obtencion de alfa-azolil-ceto-derivados.
MY118004A (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
ES488644A1 (es) Procedimiento para la obtencion de derivados de 1-aliltria- zol de efecto protector para las plantas
JPS57169473A (en) Novel bactericidal triazole derivative
FR2334676A1 (fr) Ethers triazoliques substitues utiles comme fongicides
GB966283A (en) Agents for combatting undesired plant growth
ES463162A1 (es) Procedimiento para la obtencion de derivados de 4,5-dicloro-imidazol.
ES481526A1 (es) Procedimiento de obtencion de derivados del 1,2,4-triazol.
GB1108288A (en) Improvements in or relating to pyrimidine compounds