NO942918L - Reversering av flerlegemiddelresistens av tetraaryletylener - Google Patents

Reversering av flerlegemiddelresistens av tetraaryletylener

Info

Publication number
NO942918L
NO942918L NO942918A NO942918A NO942918L NO 942918 L NO942918 L NO 942918L NO 942918 A NO942918 A NO 942918A NO 942918 A NO942918 A NO 942918A NO 942918 L NO942918 L NO 942918L
Authority
NO
Norway
Prior art keywords
tetraarylethylenes
reversal
multidrug resistance
certain
tumors
Prior art date
Application number
NO942918A
Other languages
English (en)
Other versions
NO942918D0 (no
Inventor
Sai Prasad Sunkara
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO942918D0 publication Critical patent/NO942918D0/no
Publication of NO942918L publication Critical patent/NO942918L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)

Abstract

Visse tetraaryletylener re- verserer legemiddelresistens i fler- legemiddelresistente tumorer. Disse forbindelser virker tilsynelatende ved inhibering av en P-glykoproteinpumpe som blir aktivert i et sent trinn for tumorutvikling, og som naturlig er til stede i tumorer fra visse opprinnelser.
NO942918A 1992-02-06 1994-08-05 Reversering av flerlegemiddelresistens av tetraaryletylener NO942918L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83254192A 1992-02-06 1992-02-06
PCT/US1993/000190 WO1993015733A1 (en) 1992-02-06 1993-01-11 Reversal of multi-drug resistance by tetraarylethylenes

Publications (2)

Publication Number Publication Date
NO942918D0 NO942918D0 (no) 1994-08-05
NO942918L true NO942918L (no) 1994-08-05

Family

ID=25261952

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942918A NO942918L (no) 1992-02-06 1994-08-05 Reversering av flerlegemiddelresistens av tetraaryletylener

Country Status (19)

Country Link
US (2) US5523304A (no)
EP (1) EP0624090B1 (no)
JP (1) JPH07503728A (no)
KR (1) KR950700061A (no)
AT (1) ATE142879T1 (no)
AU (1) AU668910B2 (no)
CA (1) CA2129143C (no)
DE (1) DE69304895T2 (no)
DK (1) DK0624090T3 (no)
ES (1) ES2094525T3 (no)
GR (1) GR3021811T3 (no)
HU (1) HUT75163A (no)
IL (1) IL104599A (no)
MX (1) MX9300578A (no)
NO (1) NO942918L (no)
NZ (1) NZ246818A (no)
TW (1) TW226330B (no)
WO (1) WO1993015733A1 (no)
ZA (1) ZA93690B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996006604A2 (en) 1994-08-31 1996-03-07 Eli Lilly And Company Methods for identifying and treating resistant tumors
EP0814081A1 (en) * 1996-06-17 1997-12-29 Eli Lilly And Company Drug resistance and multidrug resistance modulators
US6162616A (en) * 1997-04-16 2000-12-19 Millennium Pharmaceuticals, Inc. Multidrug resistance-associated polypeptide
US5776939A (en) * 1997-06-12 1998-07-07 Eli Lilly And Company Drug resistance and multidrug resistance modulators
AU6366000A (en) * 1999-07-23 2001-02-13 Colorado State University Research Foundation Multidrug resistance pump inhibitors and uses thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
FR2906533B1 (fr) * 2006-09-28 2013-02-22 Pf Medicament Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations
US10935552B2 (en) * 2015-06-24 2021-03-02 The Hong Kong University Of Science And Technology Aie luminogens for visualization and treatment of cancer
AU2016298175B2 (en) 2015-07-28 2022-01-06 University Of Iowa Research Foundation Compositions and methods of treating cancer
US9980951B2 (en) * 2015-12-17 2018-05-29 University Of Iowa Research Foundation Image guided therapy for cancer
WO2017223565A1 (en) 2016-06-24 2017-12-28 University Of Iowa Research Foundation Compositions and methods of treating melanoma
US11529335B2 (en) 2020-07-31 2022-12-20 University Of Iowa Research Foundation Compositions and methods for treating cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2914563A (en) * 1957-08-06 1959-11-24 Wm S Merrell Co Therapeutic composition
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4990538A (en) * 1989-08-23 1991-02-05 Harris Adrian L Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs
ZA908852B (en) * 1989-11-13 1991-09-25 Merrell Dow Pharma Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones
US5182293A (en) * 1989-11-13 1993-01-26 Merrell Dow Pharmaceuticals Inc. Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones

Also Published As

Publication number Publication date
KR950700061A (ko) 1995-01-16
ES2094525T3 (es) 1997-01-16
JPH07503728A (ja) 1995-04-20
IL104599A (en) 1997-01-10
AU668910B2 (en) 1996-05-23
TW226330B (no) 1994-07-11
ZA93690B (en) 1993-09-06
NO942918D0 (no) 1994-08-05
DK0624090T3 (da) 1996-11-11
US5665780A (en) 1997-09-09
GR3021811T3 (en) 1997-02-28
CA2129143A1 (en) 1993-08-19
HUT75163A (en) 1997-04-28
ATE142879T1 (de) 1996-10-15
EP0624090A1 (en) 1994-11-17
MX9300578A (es) 1993-08-01
HU9402284D0 (en) 1994-10-28
DE69304895T2 (de) 1997-02-06
CA2129143C (en) 1997-05-06
WO1993015733A1 (en) 1993-08-19
IL104599A0 (en) 1993-06-10
DE69304895D1 (de) 1996-10-24
NZ246818A (en) 1997-07-27
US5523304A (en) 1996-06-04
AU3440893A (en) 1993-09-03
EP0624090B1 (en) 1996-09-18

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