ZA93690B - Reversal of multi-drug resistance by tetraarylethylenes. - Google Patents
Reversal of multi-drug resistance by tetraarylethylenes.Info
- Publication number
- ZA93690B ZA93690B ZA93690A ZA93690A ZA93690B ZA 93690 B ZA93690 B ZA 93690B ZA 93690 A ZA93690 A ZA 93690A ZA 93690 A ZA93690 A ZA 93690A ZA 93690 B ZA93690 B ZA 93690B
- Authority
- ZA
- South Africa
- Prior art keywords
- tetraarylethylenes
- drug resistance
- reversal
- certain
- tumors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83254192A | 1992-02-06 | 1992-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA93690B true ZA93690B (en) | 1993-09-06 |
Family
ID=25261952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA93690A ZA93690B (en) | 1992-02-06 | 1993-02-01 | Reversal of multi-drug resistance by tetraarylethylenes. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5523304A (xx) |
| EP (1) | EP0624090B1 (xx) |
| JP (1) | JPH07503728A (xx) |
| KR (1) | KR950700061A (xx) |
| AT (1) | ATE142879T1 (xx) |
| AU (1) | AU668910B2 (xx) |
| CA (1) | CA2129143C (xx) |
| DE (1) | DE69304895T2 (xx) |
| DK (1) | DK0624090T3 (xx) |
| ES (1) | ES2094525T3 (xx) |
| GR (1) | GR3021811T3 (xx) |
| HU (1) | HUT75163A (xx) |
| IL (1) | IL104599A (xx) |
| MX (1) | MX9300578A (xx) |
| NO (1) | NO942918L (xx) |
| NZ (1) | NZ246818A (xx) |
| TW (1) | TW226330B (xx) |
| WO (1) | WO1993015733A1 (xx) |
| ZA (1) | ZA93690B (xx) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996006604A2 (en) | 1994-08-31 | 1996-03-07 | Eli Lilly And Company | Methods for identifying and treating resistant tumors |
| AU3486297A (en) * | 1996-06-17 | 1998-01-07 | Eli Lilly And Company | Drug resistance and multidrug resistance modulators |
| US6162616A (en) * | 1997-04-16 | 2000-12-19 | Millennium Pharmaceuticals, Inc. | Multidrug resistance-associated polypeptide |
| US5776939A (en) * | 1997-06-12 | 1998-07-07 | Eli Lilly And Company | Drug resistance and multidrug resistance modulators |
| AU6366000A (en) * | 1999-07-23 | 2001-02-13 | Colorado State University Research Foundation | Multidrug resistance pump inhibitors and uses thereof |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| FR2906533B1 (fr) * | 2006-09-28 | 2013-02-22 | Pf Medicament | Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations |
| CN111909114A (zh) * | 2015-06-24 | 2020-11-10 | 香港科技大学 | 用于癌症的可视化和治疗的aie发光体 |
| US10729669B2 (en) | 2015-07-28 | 2020-08-04 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| US9980951B2 (en) * | 2015-12-17 | 2018-05-29 | University Of Iowa Research Foundation | Image guided therapy for cancer |
| WO2017223565A1 (en) | 2016-06-24 | 2017-12-28 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| US11529335B2 (en) | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2914563A (en) * | 1957-08-06 | 1959-11-24 | Wm S Merrell Co | Therapeutic composition |
| US5236899A (en) * | 1987-11-16 | 1993-08-17 | Merck & Co., Inc. | 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance |
| US4990538A (en) * | 1989-08-23 | 1991-02-05 | Harris Adrian L | Use of toremifene and its metabolites for the reversal of multidrug resistance of cancer cells against cytotoxic drugs |
| ZA908852B (en) * | 1989-11-13 | 1991-09-25 | Merrell Dow Pharma | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones |
| US5182293A (en) * | 1989-11-13 | 1993-01-26 | Merrell Dow Pharmaceuticals Inc. | Treatment of multi-drug resistant tumors with pyridyloxazole-2-ones |
-
1993
- 1993-01-11 DK DK93903052.4T patent/DK0624090T3/da active
- 1993-01-11 JP JP5514060A patent/JPH07503728A/ja active Pending
- 1993-01-11 EP EP93903052A patent/EP0624090B1/en not_active Expired - Lifetime
- 1993-01-11 DE DE69304895T patent/DE69304895T2/de not_active Expired - Fee Related
- 1993-01-11 ES ES93903052T patent/ES2094525T3/es not_active Expired - Lifetime
- 1993-01-11 HU HU9402284A patent/HUT75163A/hu unknown
- 1993-01-11 NZ NZ246818A patent/NZ246818A/en unknown
- 1993-01-11 CA CA002129143A patent/CA2129143C/en not_active Expired - Fee Related
- 1993-01-11 KR KR1019940702685A patent/KR950700061A/ko not_active Application Discontinuation
- 1993-01-11 AT AT93903052T patent/ATE142879T1/de not_active IP Right Cessation
- 1993-01-11 WO PCT/US1993/000190 patent/WO1993015733A1/en active IP Right Grant
- 1993-01-11 AU AU34408/93A patent/AU668910B2/en not_active Ceased
- 1993-02-01 ZA ZA93690A patent/ZA93690B/xx unknown
- 1993-02-02 TW TW082100675A patent/TW226330B/zh active
- 1993-02-03 MX MX9300578A patent/MX9300578A/es not_active IP Right Cessation
- 1993-02-03 IL IL10459993A patent/IL104599A/xx not_active IP Right Cessation
-
1994
- 1994-08-05 NO NO942918A patent/NO942918L/no unknown
- 1994-12-15 US US08/357,361 patent/US5523304A/en not_active Expired - Fee Related
-
1995
- 1995-12-06 US US08/568,067 patent/US5665780A/en not_active Expired - Fee Related
-
1996
- 1996-11-28 GR GR960403202T patent/GR3021811T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0624090T3 (da) | 1996-11-11 |
| NO942918D0 (xx) | 1994-08-05 |
| JPH07503728A (ja) | 1995-04-20 |
| AU668910B2 (en) | 1996-05-23 |
| WO1993015733A1 (en) | 1993-08-19 |
| TW226330B (xx) | 1994-07-11 |
| GR3021811T3 (en) | 1997-02-28 |
| HU9402284D0 (en) | 1994-10-28 |
| KR950700061A (ko) | 1995-01-16 |
| US5523304A (en) | 1996-06-04 |
| IL104599A0 (en) | 1993-06-10 |
| CA2129143C (en) | 1997-05-06 |
| HUT75163A (en) | 1997-04-28 |
| US5665780A (en) | 1997-09-09 |
| AU3440893A (en) | 1993-09-03 |
| EP0624090B1 (en) | 1996-09-18 |
| ES2094525T3 (es) | 1997-01-16 |
| MX9300578A (es) | 1993-08-01 |
| DE69304895T2 (de) | 1997-02-06 |
| NZ246818A (en) | 1997-07-27 |
| EP0624090A1 (en) | 1994-11-17 |
| CA2129143A1 (en) | 1993-08-19 |
| ATE142879T1 (de) | 1996-10-15 |
| DE69304895D1 (de) | 1996-10-24 |
| IL104599A (en) | 1997-01-10 |
| NO942918L (no) | 1994-08-05 |
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