NO942274L - 2-piperazinon-forbindelser og deres anvendelse - Google Patents

2-piperazinon-forbindelser og deres anvendelse

Info

Publication number
NO942274L
NO942274L NO942274A NO942274A NO942274L NO 942274 L NO942274 L NO 942274L NO 942274 A NO942274 A NO 942274A NO 942274 A NO942274 A NO 942274A NO 942274 L NO942274 L NO 942274L
Authority
NO
Norway
Prior art keywords
group
formula
hydrogen atom
halogen atom
adhesion
Prior art date
Application number
NO942274A
Other languages
English (en)
Other versions
NO942274D0 (no
Inventor
Hirosada Sugihara
Zenichi Terashita
Hideto Fukushi
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO942274D0 publication Critical patent/NO942274D0/no
Publication of NO942274L publication Critical patent/NO942274L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Det blir beskrevet forbindelser med formelen C-N-CH-C-N hvor A står for amidinogruppe eller en eventuelt substituert aminoetylgruppe; R10 står for en art valgt fra en gruppe bestående av nitrogruppe, halogenatomer, lavalkenylgrupper, lavalkynylgrupper, lavalkyloksykar- bonylgrupper, hydroksymetylgrupper, formylgrupper og grupper representert ved formelen OR11 hvor R11 er hydrogenatom eller en lavalkyl, en lavalkenyl, en lavalkynyl, en lavalkanoyl, en karbamoyl eller en metansulfonylgruppe, som hver kan være substituert; R12 og R1^ står henholdsvis for hydrogenatom, hydroksyl- gruppe, en lavalkoksygruppe eller et halogenatom; X står for hydroksylgruppe, p-hydroksyfenylgruppe eller en eventuelt esterifisert eller amldert karboksylgrup- pe; Y står for en eventuelt esterifisert eller amidert karboksylgruppe; og n står for l eller 2], eller et salt av dette, som middel for hemming av adhesjon av celler som omfatter nevnte forbindelse. Disse har en kraftigere og mer langvarig aktivitet for hemming av celleadhesjon enn kjente midler, og er således anvendelig som et oralt adminlstrerbart antitrombonisk middel.
NO942274A 1993-06-17 1994-06-16 2-piperazinon-forbindelser og deres anvendelse NO942274L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14613693 1993-06-17
JP25414293 1993-10-21

Publications (2)

Publication Number Publication Date
NO942274D0 NO942274D0 (no) 1994-06-16
NO942274L true NO942274L (no) 1994-12-19

Family

ID=26477044

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942274A NO942274L (no) 1993-06-17 1994-06-16 2-piperazinon-forbindelser og deres anvendelse

Country Status (11)

Country Link
US (1) US5550131A (no)
EP (1) EP0643072B1 (no)
KR (1) KR950000683A (no)
CN (1) CN1098409A (no)
AT (1) ATE176912T1 (no)
AU (1) AU6477194A (no)
CA (1) CA2126026A1 (no)
DE (1) DE69416629T2 (no)
FI (1) FI942881A (no)
HU (1) HUT70045A (no)
NO (1) NO942274L (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033982A1 (en) * 1995-04-26 1996-10-31 Takeda Chemical Industries, Ltd. Piperazinones useful as inhibitors of platelet aggregation
CA2180206A1 (en) * 1995-06-30 1996-12-31 Motoya Ohshika Freeze-dried preparation for pharmaceutical use
MX9801716A (es) * 1995-08-30 1998-05-31 Searle & Co Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5919777A (en) * 1996-04-24 1999-07-06 Novo Nordisk A/S Compounds with growth hormone releasing properties
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
WO1998039324A1 (en) 1997-03-07 1998-09-11 Takeda Chemical Industries, Ltd. 2-peperazinone-1-acetic acid derivatives and their use
CA2283704A1 (en) * 1997-03-24 1998-10-01 Merck & Co., Inc. Thrombin inhibitors
US6133256A (en) * 1997-04-14 2000-10-17 Cor Therapeutics Inc Selective factor Xa inhibitors
AU6896298A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
AU6896398A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
JP2002516326A (ja) * 1998-05-26 2002-06-04 メルク エンド カムパニー インコーポレーテッド イミダゾピリジン系トロンビン阻害薬
CA2380218A1 (en) 1999-07-26 2001-02-01 Santen Pharmaceutical Co., Ltd. Novel thiazine or pyrazine derivatives
KR100360122B1 (ko) * 2000-09-14 2002-11-07 대한민국(서울대학교 총장) 제충 및 제초 기능을 갖는 폴리에틸렌 멀칭필름
US7354923B2 (en) * 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
WO2003013571A1 (en) 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7732451B2 (en) * 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7456184B2 (en) * 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7655658B2 (en) * 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2097378C1 (ru) * 1991-03-26 1997-11-27 Ф.Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ N-АЦИЛ- α -АМИНОКИСЛОТЫ ИЛИ ИХ ФИЗИОЛОГИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ, ПРОСТЫЕ ИЛИ СЛОЖНЫЕ ЭФИРЫ, АМИДЫ ИЛИ ГИДРАТЫ И КОМПОЗИЦИЯ ИНГИБИРУЮЩАЯ СВЯЗЫВАНИЕ АДГЕЗИВНЫХ ПРОТЕИНОВ С ТРОМБОЦИТАМИ И АГРЕГАЦИЮ ТРОМБОЦИТОВ
US5294713A (en) * 1991-08-23 1994-03-15 Takeda Chemical Industries, Ltd. 2-piperazinone compounds and their use

Also Published As

Publication number Publication date
AU6477194A (en) 1994-12-22
ATE176912T1 (de) 1999-03-15
FI942881A0 (fi) 1994-06-16
EP0643072A1 (en) 1995-03-15
HU9401726D0 (en) 1994-09-28
DE69416629D1 (de) 1999-04-01
DE69416629T2 (de) 1999-07-22
HUT70045A (en) 1995-09-28
US5550131A (en) 1996-08-27
NO942274D0 (no) 1994-06-16
CA2126026A1 (en) 1994-12-18
EP0643072B1 (en) 1999-02-24
KR950000683A (ko) 1995-01-03
FI942881A (fi) 1994-12-18
CN1098409A (zh) 1995-02-08

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