NO934721L - Hemmere av HIV-protease som er nyttige for behandling av AIDS - Google Patents

Hemmere av HIV-protease som er nyttige for behandling av AIDS

Info

Publication number
NO934721L
NO934721L NO934721A NO934721A NO934721L NO 934721 L NO934721 L NO 934721L NO 934721 A NO934721 A NO 934721A NO 934721 A NO934721 A NO 934721A NO 934721 L NO934721 L NO 934721L
Authority
NO
Norway
Prior art keywords
alkyl
heterocycle
aids
inhibitors
treatment
Prior art date
Application number
NO934721A
Other languages
English (en)
Other versions
NO934721D0 (no
Inventor
Bruce Anthony Dressman
Marlys Hammond
Stephen Warren Kaldor
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO934721D0 publication Critical patent/NO934721D0/no
Publication of NO934721L publication Critical patent/NO934721L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C07D215/60—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Det blir beskrevet en forbindelse med formel (I):. hvor. R og R° uavhengig er valgt blant hydrogen, ( C^- C^)alkyl, aryltC^)alkyl,. heterocyklus(C-C)alkyl eller umettet heterocvklus(C-C)alkyl; eller. R og R*1 er kombinert med nitrogenet til hvilket de er bundet for å danne en heterocyklus eller umettet heterocyklus med den forutsetning at nitrogen-atomet Ikke kan være kvaternlsert;. Z er en gruppe som har strukturen:. Rer hydrogen, halo, (Cy-C^alkyl, aryl( C^- C^)alkyl, (Cj-Cf,Jalkoksy, (Cj-Cfjjalkyltio, amino, (^-0)alkylamlno, di(C1-C4 )alkylamlno, karbamoyl eller N-(C1-C4 )alkylkarbamoyl;. rer aryl, heterocyklus, umettet heterocyklus, (C-^Jcykloalkyl eller -S-R, hvor Rer aryl, heterocyklus,. umettet heterocyklus eller (C5-C7 )cykloalkyl;. X er en gruppe som har strukturen:. eller et farmasøytisk akseptabelt salt av disse.Forbindelsen med formel (I) er hemmere av HIV-protease og er anvendelige i farmasøytisk formuleringer for behandling og/eller forhindring av HIV-infeksJon og/eller AIDS.
NO934721A 1992-12-22 1993-12-20 Hemmere av HIV-protease som er nyttige for behandling av AIDS NO934721L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US99562192A 1992-12-22 1992-12-22

Publications (2)

Publication Number Publication Date
NO934721D0 NO934721D0 (no) 1993-12-20
NO934721L true NO934721L (no) 1994-06-23

Family

ID=25542022

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934721A NO934721L (no) 1992-12-22 1993-12-20 Hemmere av HIV-protease som er nyttige for behandling av AIDS

Country Status (15)

Country Link
EP (1) EP0609625A1 (no)
JP (1) JPH06256277A (no)
KR (1) KR940014336A (no)
CN (1) CN1092410A (no)
AU (1) AU5252993A (no)
BR (1) BR9305161A (no)
CA (1) CA2112052A1 (no)
CO (1) CO4180513A1 (no)
CZ (1) CZ281393A3 (no)
FI (1) FI935780A (no)
HU (1) HUT69703A (no)
IL (1) IL108098A0 (no)
MX (1) MX9308025A (no)
NO (1) NO934721L (no)
PL (1) PL301578A1 (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
US5747540A (en) * 1996-10-21 1998-05-05 Merck & Co., Inc. HIV protease inhibitors useful for the treatment of AIDS
CA2401749A1 (en) 2000-03-23 2001-09-27 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
EP1666452A2 (en) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
AU7622500A (en) * 2000-09-29 2002-07-01 Neurogen Corp High affinity small molecule c5a receptor modulators
IL159897A0 (en) * 2001-07-19 2004-06-20 Cv Therapeutics Inc Substituted piperazine compounds and their use as fatty acid oxidation inhibitors
EP1432674A2 (en) 2001-10-04 2004-06-30 Elan Pharmaceuticals, Inc. Hydroxypropylamines
WO2004058686A1 (en) 2002-04-30 2004-07-15 Elan Pharmaceuticals, Inc. Hydroxypropyl amides for the treatment of alzheimer’s disease
JP4721214B2 (ja) * 2004-09-14 2011-07-13 日本曹達株式会社 ピリジルメチルカルバミン酸エステル化合物及びピリジルメチルアミン化合物の製造方法
JP4698991B2 (ja) * 2004-09-14 2011-06-08 日本曹達株式会社 ピリジルメチルカルバミン酸エステル化合物、その製造方法及びピリジルメチルアミン化合物の製造方法
JP2008535863A (ja) 2005-04-08 2008-09-04 コメンティス，インコーポレーテッド β−セクレターゼ活性を阻害する化合物およびその使用方法
WO2010002994A1 (en) * 2008-07-01 2010-01-07 Purdue Research Foundation Nonpeptide hiv-1 protease inhibitors
CN110872251A (zh) * 2019-11-28 2020-03-10 卡博金艾美斯医药(上海)有限公司 N-乙基吡啶甲胺三氟乙酸盐及其晶体、制备工艺和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0361341A3 (en) * 1988-09-28 1991-07-03 Miles Inc. Therapeutics for aids based on inhibitors of hiv protease
WO1991008221A1 (en) * 1989-12-04 1991-06-13 Wisconsin Alumni Research Foundation Peptide inhibitors of hiv protease
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives

Also Published As

Publication number Publication date
HU9303677D0 (en) 1994-04-28
MX9308025A (es) 1994-08-31
PL301578A1 (en) 1994-06-27
NO934721D0 (no) 1993-12-20
AU5252993A (en) 1994-07-07
FI935780A (fi) 1994-06-23
CZ281393A3 (en) 1994-07-13
CA2112052A1 (en) 1994-06-23
FI935780A0 (fi) 1993-12-21
KR940014336A (ko) 1994-07-18
EP0609625A1 (en) 1994-08-10
JPH06256277A (ja) 1994-09-13
HUT69703A (en) 1995-09-28
CO4180513A1 (es) 1995-06-07
IL108098A0 (en) 1994-04-12
BR9305161A (pt) 1994-11-01
CN1092410A (zh) 1994-09-21

Similar Documents

Publication Publication Date Title
NO934721L (no) Hemmere av HIV-protease som er nyttige for behandling av AIDS
NZ505675A (en) N-alkylamide substituted hydroxamic acid derivatives are used as antibacterial agents
HUT74367A (en) Fungicidal alpha-aryl-substituted cyclic amide derivatives, fungicid compositions containing these as active ingredients and using thereof
NO905322L (no) Aminosyrederivater.
EP0638560A4 (en) MEDICINE FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND *.
DK0951474T3 (da) Nye cyclosporinderivater, deres fremstilling og farmaceutiske præparater deraf
NO934719L (no) Hemmere av HIV-protease som er nyttige for behandling av AIDS
FI915819A (fi) Hiv- proteas-inhibitorer.
DK1142887T3 (da) 5,6-Dihydropyronderivater som proteaseinhibitorer og antivirale midler
NZ507560A (en) Hydroxamic acid derivatives as antibacterials
SE0201194D0 (sv) New compounds
WO1995014011A3 (en) 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
AU6948091A (en) Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use
KR930002319A (ko) Aids 치료에 유용한 hiv 프로테아제의 억제제
CA2183234A1 (en) Agent for prophylaxis and treatment of thromboxane a2-mediated diseases
WO1990003172A3 (en) Bile acids for treatment of viral infections
TH14432A (th) สารยับยั้ง hiv โปรตีเอสที่เป็นประโยชน์สำหรับการบำบัดเอดส์
TH13345EX (th) อนุพันธ์กรดฟินิลแอซิติกที่ถูกแทนที่เชิงเฮทเทอโรไซคลิก กระบวนการสำหรับการเตรียมสารและการนำไปใช้ในยา