NO932769L - Faktor iia inhibitorer - Google Patents

Faktor iia inhibitorer

Info

Publication number
NO932769L
NO932769L NO93932769A NO932769A NO932769L NO 932769 L NO932769 L NO 932769L NO 93932769 A NO93932769 A NO 93932769A NO 932769 A NO932769 A NO 932769A NO 932769 L NO932769 L NO 932769L
Authority
NO
Norway
Prior art keywords
group
present
nle
nal
ile
Prior art date
Application number
NO93932769A
Other languages
English (en)
Other versions
NO932769D0 (no
Inventor
Johannes Wilhelmus Fran Nispen
Henricus Carl Joseph Ottenheym
Jacobus Albertus Maria Peters
Arie Visser
Willemientje Jetten
Original Assignee
Akzo Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nv filed Critical Akzo Nv
Publication of NO932769D0 publication Critical patent/NO932769D0/no
Publication of NO932769L publication Critical patent/NO932769L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Forbindelser med formelen: X Y Z A P Q T som er meget kraftige, selektive faktor Ila-inhibitorer er beskrevet. X kan, når den er tilstede, være bundet til T og være H, CH3, acyl eller en vanlig beskyttende gruppe. Y er D-DPA, D-Phe, D-Val, D-Ile, D-Nle, fenylsulfonyl, dansyl eller 8-(l,2,3,4- tetrahydrokinolinsulfonyl). Z er, når den er tilstede, Gly, L/D-Pro, L/D-Ala, L/D-Leu, aminoisosmørsyre, en substituert eller usubstituert L/D-Pro-ring-homolog eller L/D-Val. A kan være (I) hvor K er -CO-CF,- (CO) 5- , -(CD)d-NH-, - (CO)d-(CH2)p- eller -CH(OH)-(CH2) p-, d er 0-2, p og q er 0-5 og s er O eller l, eller A er en prolin-lignende gruppe. P og Q (hvis Q er tilstede) er substituerte eller usubstituerte aminosyrer valgt fra L/D-Phe, L/D-Cha, L/D-Nal(l), L/D-Nal(2), L/D-fenyl- glycinyl, L/D-Leu, L/D-Ile, L/D-Nle, L/D-Arg, L/D-Lys eller L/D-His. T kan vsre bundet til X eller kan være -OH, -OR4, -NH2, -NHR* eller -NR"R5, hvor R4 og R5 uavhengig er valgt fra alkyl, aryl, (ar)alkyl, og hvor R4 og R5 kan være cyklisk bundet til hverandre.
NO93932769A 1991-02-04 1993-08-03 Faktor iia inhibitorer NO932769L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP91200201 1991-02-04
PCT/EP1992/000273 WO1992013877A1 (en) 1991-02-04 1992-02-04 Factor iia inhibitors

Publications (2)

Publication Number Publication Date
NO932769D0 NO932769D0 (no) 1993-08-03
NO932769L true NO932769L (no) 1993-08-03

Family

ID=8207509

Family Applications (1)

Application Number Title Priority Date Filing Date
NO93932769A NO932769L (no) 1991-02-04 1993-08-03 Faktor iia inhibitorer

Country Status (11)

Country Link
US (1) US5719128A (no)
EP (2) EP0570428B1 (no)
JP (1) JPH06505001A (no)
KR (1) KR930703348A (no)
AT (1) ATE174603T1 (no)
AU (1) AU656947B2 (no)
CA (1) CA2101331A1 (no)
DE (1) DE69227895D1 (no)
FI (1) FI933454A (no)
NO (1) NO932769L (no)
WO (1) WO1992013877A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391705A (en) * 1991-03-15 1995-02-21 Merrell Dow Pharmaceuticals Inc. Polyfluorinated tripeptide thrombin inhibitors
AU1068295A (en) * 1993-12-09 1995-06-27 Novartis Ag Process for the production of combinatorial compound libraries
US6069232A (en) * 1995-10-02 2000-05-30 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
US5739354A (en) * 1996-03-26 1998-04-14 Hoechst Marion Roussel, Inc. Process for the preparation of N-methyl-D-phenylalanyl-N- 1- 3- (aminoiminomethyl)amino!propyl!-3,3-difluoro-2-oxohexyl!-L-prolinamide
EP1425296B1 (de) 2001-09-10 2011-04-13 Novel Science International GmbH Organische verbindungen mit biologischer wirkung als thrombinhemmer und ihre verwendung
DE602005023429D1 (de) 2004-10-19 2010-10-21 Lonza Ag Verfahren zur festphasen-peptidsynthese
US10526371B2 (en) 2015-07-13 2020-01-07 Universiteit Gent Hydrogel-forming peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4318904A (en) * 1980-04-25 1982-03-09 Research Corporation Peptide affinity labels for thrombin and other trypsin-like proteases
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
IT251700Y1 (it) * 2000-01-21 2004-01-20 Lotto Sport Italia Spa Struttura di suola

Also Published As

Publication number Publication date
FI933454A0 (fi) 1993-08-03
DE69227895D1 (de) 1999-01-28
ATE174603T1 (de) 1999-01-15
CA2101331A1 (en) 1992-08-05
EP0570428A1 (en) 1993-11-24
NO932769D0 (no) 1993-08-03
WO1992013877A1 (en) 1992-08-20
JPH06505001A (ja) 1994-06-09
FI933454A (fi) 1993-08-03
US5719128A (en) 1998-02-17
KR930703348A (ko) 1993-11-29
EP0570428B1 (en) 1998-12-16
EP0498508A1 (en) 1992-08-12
AU1193392A (en) 1992-09-07
AU656947B2 (en) 1995-02-23

Similar Documents

Publication Publication Date Title
HUP9901209A2 (hu) Opioid analóg peptid vegyületek, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
HUP9901319A2 (hu) 9-Hidroxi-riszperidon zsírsavészterek vizes szuszpenziói, előállításuk és alkalmazásuk
IE820465L (en) Peptides
KR830006219A (ko) 아미노산 유도체의 제조방법
ATE194846T1 (de) Zyklische antimikrobielle peptide und deren herstellung
DE3881592D1 (de) Lhrh antagonisten, deren herstellung und entsprechende pharmazeutische zubereitungen.
ATE174603T1 (de) Faktor iia inhibitoren
KR910014395A (ko) 신규 화합물
ATE63750T1 (de) Peptid, dessen herstellung und benutzung.
KR900016238A (ko) 신규 화합물
EP0206090A3 (en) Peptide renin inhibitors
MY106287A (en) Acid addition salts of amidated taurine or glycine, their preparation and use
KR850006941A (ko) 데스-프로린 바조프레신 길항제의 제조방법
ATE47880T1 (de) Vorlaeufer eines an dem c-ende amidierten peptids und dessen herstellung.
KR920012008A (ko) 페닐알킬아미노알킬 화합물과 이들의 제법 및 이 화합물들을 포함하는 약물
ES536117A0 (es) Un procedimiento para preparar heptapeptidos y hexapeptidos ciclicos antagonistas de la vasopresina
ATE6148T1 (de) Hexapeptide, deren herstellung, deren anwendung in arzneimitteln und sie enthaltende zusammensetzungen.
EP0361977A3 (en) Peptides having t cell suppressor activity
DE3867039D1 (de) Vincristin enthaltendes produkt.
EP0307662A3 (en) Enkephalin analogs
IE38320L (en) Nor-morphines and nor-codeines
IT1230733B (it) Analoghi della timopentina retro invertita a tutti i legami, il metodo per la loro sintesi ed il loro impiego per la preparazione di composizioni farmaceutiche.
ATE10934T1 (de) Peptid, verfahren zu dessen herstellung und dessen verwendung.
JPS5772950A (en) Tetrapeptide derivative, its preparation and analgesic agent
JPS6450896A (en) Contraction suppressing peptide