Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/726,654external-prioritypatent/US5244915A/en
Application filed by Warner Lambert CofiledCriticalWarner Lambert Co
Publication of NO930711D0publicationCriticalpatent/NO930711D0/en
Publication of NO930711LpublicationCriticalpatent/NO930711L/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
Det beskrives nye a-substituerte Trp-dipeptoid-derivater som er ringsluttet i den C-terminale ende som midler ved behandling av fedme, hypersekresjon av mavesaft i tarmen, gastrin-avhengige svulster eller som antipsykotika. Forbindelsene er dessuten angstdempende midler og anti-ulcusmidler. De er dessuten egnede midler for forhindring av abstinenssymptomer ved kronisk behandling med, eller bruk av, nikotin, diazepam, alkohol, kokain, koffein eller opioider. Forbindelsene i henhold til oppfinnelsen er også egnet ved behandling og/eller forhindring av panikkanfall.Det beskrives også farmasøytiske preparater og fremgangsmåter for behandling ved bruk av forbindelsene, så vel som fremgangsmåter for fremstilling av disse, samt nye mellom-produkter egnet for deres fremstilling. Et ytterligere trekk ved oppfinnelsen er bruken av forbindelsene i diagnostiske sammensetninger.New α-substituted Trp-dipeptoid derivatives are described which are cyclized at the C-terminal end as agents in the treatment of obesity, hypersecretion of gastric juice in the intestine, gastrin-dependent tumors or as antipsychotics. The compounds are also anxiolytics and anti-ulcers. They are also suitable agents for the prevention of withdrawal symptoms in chronic treatment with, or use of, nicotine, diazepam, alcohol, cocaine, caffeine or opioids. The compounds of the invention are also suitable for the treatment and / or prevention of panic attacks. Pharmaceutical compositions and methods of treatment using the compounds are also described, as well as methods for their preparation, as well as novel intermediates suitable for their preparation. A further feature of the invention is the use of the compounds in diagnostic compositions.
NO93930711A1990-08-311993-02-26
AMINO ACID DERIVATIVES CIRCULATED AT THE C-TERMINAL END
NO930711L
(en)
Composition, use of a combination of ipratropium or a salt thereof and xylometazoline or a salt thereof, and methods for the treatment of a condition selected from the group consisting of symptoms associated with the common cold and symptoms associated with rhinitis and to stabilize an aqueous solution of ipratropium or a salt thereof and xylometazoline or a salt thereof
Compound, method of treating a patient who has, or preventing a patient from catching, a disease or condition, use of a compound, and method for making a compound
An immunological method for detecting antibodies directed against tissue transglutaminase (TTG), use of TTG in diagnosis and therapy control, and an oral pharmaceutical agent containing TTG
Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds
Pharmaceutically acceptable compound or salt thereof, methods of treating or preventing disease and preparing a compound, use of a compound or salt, and pharmaceutical composition
Compound, methods of treating a patient who has or prevent a patient from contracting a disease or condition and preparing a compound, and, using a compound
Combination therapy for hiv infection using the hiv protease inhibitor indinavir adn the reverse transcriptase inhibitor 3tc, optionally together with azt, ddi or ddc.
ALKYLIDE ANALOGS OF 1'-AMINOSPIRO- [ISOCHINOLIN-4 (1H), 3'-PYRROLIDIN] -1.2 ', 3.5' (2H) TETRONONS, USED AS ALDOSE REDUCTASE INHIBITORS IN VIVO