NO930252L - Crf analoger - Google Patents
Crf analogerInfo
- Publication number
- NO930252L NO930252L NO93930252A NO930252A NO930252L NO 930252 L NO930252 L NO 930252L NO 93930252 A NO93930252 A NO 93930252A NO 930252 A NO930252 A NO 930252A NO 930252 L NO930252 L NO 930252L
- Authority
- NO
- Norway
- Prior art keywords
- ala
- leu
- glu
- gln
- ile
- Prior art date
Links
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 3
- 102100027467 Pro-opiomelanocortin Human genes 0.000 abstract 2
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 abstract 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
- HNDVDQJCIGZPNO-RXMQYKEDSA-N D-histidine Chemical compound OC(=O)[C@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-RXMQYKEDSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 108010042362 beta-Lipotropin Proteins 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 abstract 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 abstract 1
- 229960000258 corticotropin Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- AOCUKGFDRUSDQH-PIKKTMSISA-N ocrf Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)CC)[C@@H](C)O)C(C)C)C(C)O)C1=CNC=N1 AOCUKGFDRUSDQH-PIKKTMSISA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Analoger av CRF som er basert på hCRF, oCRF og alfa-helix- formet CRF som kan tilføres for å oppnå en vesentlig økning av ACTH, (J-endorfin, p-lipotropin eller andre produkter av pro-opiomelanokortingenet og kortikosteronnivåer er beskrevet. Analoger inkluderer dem med formelen (se SEQ ID NO:9): Y-Ser-Xaa2-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe- His-Leu-Leu-Arg-Glu-Val-Leu-Xaa2o-Xaa21~Xaa22~Xaa23~Xaa24~ Xaa25-Gln-Leu-Ala-Gln-Gln-Ala-Xaa32-Ser-Asn-Arg-Lys-Leu- Xaa3Q-Xaa3g-Ile-Xaa4i-NH2 hvori Y er en acylgruppe med 7 eller færre karbonatomer eller hydrogen, Xaa2 er Glu eller Gin, Xaa2o er Ala eller Glu, Xaa2i er Met eller Nle, Xaa22 er Ala eller Thr, Xaa23 er Ar9 eller Lys, Xaa24 er D-Ala eller Ala, Xaa25 er Glu eller Asp, Xaa32 er D-His eller His, Xaa38 er Met, Nle eller Leu, Xaa3g er Ala, Glu eller Asp, Xaa41 er Ile eller Ala, med den betingelse at imidlertid minst en av Xaa2Q °9 Xaa39 er Ala og at N-terminalen kan være forkortet med en sekvens på opptil omtrent 5 rester. Et eksempel er [Ala20]-oCRF. Disse analoger eller deres farmasøytisk tålbare salter, dispergert i en tålbar væske eller en fast bærer, kan tilføres til mennesker.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/709,091 US5235036A (en) | 1991-05-31 | 1991-05-31 | Crf analogs |
| PCT/US1992/004525 WO1992021372A1 (en) | 1991-05-31 | 1992-05-29 | Crf analogs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO930252D0 NO930252D0 (no) | 1993-01-26 |
| NO930252L true NO930252L (no) | 1993-03-26 |
Family
ID=26784804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93930252A NO930252L (no) | 1991-05-31 | 1993-01-26 | Crf analoger |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO930252L (no) |
-
1993
- 1993-01-26 NO NO93930252A patent/NO930252L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO930252D0 (no) | 1993-01-26 |
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