NO922961L - Oral farmasoeytisk sammensetning inneholdende cyklosporin og fremgangsmaate ved fremstilling derav - Google Patents

Oral farmasoeytisk sammensetning inneholdende cyklosporin og fremgangsmaate ved fremstilling derav

Info

Publication number
NO922961L
NO922961L NO92922961A NO922961A NO922961L NO 922961 L NO922961 L NO 922961L NO 92922961 A NO92922961 A NO 92922961A NO 922961 A NO922961 A NO 922961A NO 922961 L NO922961 L NO 922961L
Authority
NO
Norway
Prior art keywords
cyclosporin
preparing
pharmaceutical composition
parts
procedures
Prior art date
Application number
NO92922961A
Other languages
English (en)
Other versions
NO922961D0 (no
Inventor
Erno Orban
Laszlone Tomori
Maria Kuthy
Tibor Balogh
Laszlo Jaszlits
Imre Moravcsik
Istvan Kovacs
Istvanne Jusztin
Sandor Jancso
Erzsebet Takacs
Tamasne Kiss
Antalne Kovacs
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of NO922961D0 publication Critical patent/NO922961D0/no
Publication of NO922961L publication Critical patent/NO922961L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Oppfinnelsen vedrører terapeutisk nyttige nye orale løs-ninger inneholdende cyklosporin som aktiv bestanddel, hvilke løsninger har fordelaktige absorpsjonsegenskaper. Oppfinnelsen vedrører også en fremgangsmåte ved frem-stilling av disse løsninger.Løsningene i henhold til oppfinnelsen omfatter 1 vektdel av en eller flere cyklosporin oppløst i en blanding inneholdende 4-50 volumdeler propylenglykol, 0-25 volumdeler etanol og 0,01 - 5 vektdeler av en polyoksy-etylen/polyoksypropylen blokkpolymer i homogenisert til-stand .Basert på undersøkelser utført ved 100C, viser det seg at stabiliteten av løsningene fremstilt i henhold til oppfinnelsen, ikke adskiller seg fra stabiliteten hos kommersielt tilgjengelige, orale Sandimmun løsninger.
NO92922961A 1990-11-27 1992-07-27 Oral farmasoeytisk sammensetning inneholdende cyklosporin og fremgangsmaate ved fremstilling derav NO922961L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU907653A HU208491B (en) 1990-11-27 1990-11-27 Process for producing oral pharmaceutical composition containing cyclosporin
PCT/HU1991/000050 WO1992009299A1 (en) 1990-11-27 1991-11-27 Oral pharmaceutical composition containing cyclosporin and process for preparing same

Publications (2)

Publication Number Publication Date
NO922961D0 NO922961D0 (no) 1992-07-27
NO922961L true NO922961L (no) 1992-09-23

Family

ID=10972318

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922961A NO922961L (no) 1990-11-27 1992-07-27 Oral farmasoeytisk sammensetning inneholdende cyklosporin og fremgangsmaate ved fremstilling derav

Country Status (18)

Country Link
US (1) US5430017A (no)
EP (1) EP0512109B1 (no)
JP (1) JPH082795B2 (no)
AT (1) ATE129898T1 (no)
AU (1) AU651154B2 (no)
CA (1) CA2072983A1 (no)
CS (1) CS230492A3 (no)
DE (1) DE69114476T2 (no)
DK (1) DK0512109T3 (no)
FI (1) FI923385A0 (no)
HU (1) HU208491B (no)
IL (1) IL100162A (no)
MX (1) MX9102243A (no)
NO (1) NO922961L (no)
NZ (1) NZ240762A (no)
PT (1) PT99623A (no)
WO (1) WO1992009299A1 (no)
ZA (1) ZA919352B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
DK0789580T3 (da) 1994-11-03 2002-09-09 Novartis Ag Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
US6022536A (en) * 1995-08-09 2000-02-08 Schering Corporation Combined use of interleukin 10 and cyclosporin for immunosuppression therapy
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5766629A (en) * 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
EP0789561B1 (en) * 1995-08-25 2004-04-07 Sangstat Medical Corporation Oral cyclosporin formulations
AU764599B2 (en) * 1995-08-25 2003-08-21 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
EP0988046B1 (en) 1997-01-30 2004-09-15 Novartis AG Oil-free pharmaceutical compositions containing cyclosporin a
CA2284000C (en) * 1997-03-12 2012-01-03 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
US5891845A (en) * 1997-11-21 1999-04-06 Fuisz Technologies Ltd. Drug delivery systems utilizing liquid crystal structures
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
DE69939335D1 (de) 1998-12-30 2008-09-25 Dexcel Ltd Dispergierbares konzentrat zur verabreichung von cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE290460C (no) *
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
SE8601624D0 (sv) * 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
CA1323306C (en) * 1987-03-05 1993-10-19 Mircea C. Popescu Pharmacological agent-lipid solution preparation
JP2577049B2 (ja) * 1987-06-04 1997-01-29 三共株式会社 シクロスポリン製剤
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
FR2642650B1 (fr) * 1989-02-09 1994-12-09 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine

Also Published As

Publication number Publication date
HU907653D0 (en) 1991-06-28
DE69114476T2 (de) 1996-04-18
IL100162A0 (en) 1992-08-18
ZA919352B (en) 1992-09-30
HU208491B (en) 1993-11-29
EP0512109B1 (en) 1995-11-08
FI923385A (fi) 1992-07-27
DK0512109T3 (da) 1995-12-11
MX9102243A (es) 1992-07-08
WO1992009299A1 (en) 1992-06-11
EP0512109A1 (en) 1992-11-11
ATE129898T1 (de) 1995-11-15
JPH082795B2 (ja) 1996-01-17
HUT60929A (en) 1992-11-30
DE69114476D1 (de) 1995-12-14
AU8944091A (en) 1992-06-25
JPH05503306A (ja) 1993-06-03
AU651154B2 (en) 1994-07-14
CA2072983A1 (en) 1992-05-28
NZ240762A (en) 1993-05-26
CS230492A3 (en) 1992-12-16
FI923385A0 (fi) 1992-07-27
PT99623A (pt) 1992-12-31
NO922961D0 (no) 1992-07-27
IL100162A (en) 1995-11-27
US5430017A (en) 1995-07-04

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