NO922447L - HYBRID MOLECULE WITH TRANSLOCATION REGION AND CELL BINDING REGION - Google Patents
HYBRID MOLECULE WITH TRANSLOCATION REGION AND CELL BINDING REGIONInfo
- Publication number
- NO922447L NO922447L NO92922447A NO922447A NO922447L NO 922447 L NO922447 L NO 922447L NO 92922447 A NO92922447 A NO 92922447A NO 922447 A NO922447 A NO 922447A NO 922447 L NO922447 L NO 922447L
- Authority
- NO
- Norway
- Prior art keywords
- region
- hybrid molecule
- moiety
- cell
- hybrid
- Prior art date
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- Peptides Or Proteins (AREA)
Abstract
Hybridmolekyl som omfatter en første del, en andre del og en tredje del bundet sammen med kovalente bindinger, (a) den første delen omfatter en del av det bindende området til en celle-bindende forbindelse, hvis del er i stand til å binde hybridmolekylet i oppfinnelsen til en dyrecelle; (b) den andre del som omfatter et område av en translokasjonsregion i et protein, hvis del transporterer den tredje delen over cellens cytoplasmamembran; og (c) den tredje delen som omfatter en kjemisk forbindelse som skal innføres.i cellen, forutsatt at (i) hybridmolekylet er fremstilt ved å uttrykke et rekombinant DNA-molekyl som koder for hybridmolekylet, og (ii) den andre og tredje delen er ikke deler av det samme naturlig-forekom- mende polypeptidtoksin; et rekombinant DNA-molekyl som koder for hybridmolekylet; og en fremgangsmåte for fremstilling av hybridmolekylet.A hybrid molecule comprising a first moiety, a second moiety, and a third moiety bonded together with covalent bonds; (a) the first moiety comprises a portion of the binding region of a cell-binding compound whose moiety is capable of binding the hybrid the invention of an animal cell; (b) the second portion comprising a region of a translocation region of a protein whose portion carries the third portion across the cytoplasmic membrane of the cell; and (c) the third part comprising a chemical compound to be introduced into the cell, provided that (i) the hybrid molecule is prepared by expressing a recombinant DNA molecule encoding the hybrid molecule, and (ii) the second and third moieties are not parts of the same naturally occurring polypeptide toxin; a recombinant DNA molecule encoding the hybrid molecule; and a process for preparing the hybrid molecule.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45609589A | 1989-12-22 | 1989-12-22 | |
US53827690A | 1990-06-14 | 1990-06-14 | |
PCT/US1990/007619 WO1991009871A1 (en) | 1989-12-22 | 1990-12-21 | Hybrid molecules having translocation region and cell-binding region |
Publications (2)
Publication Number | Publication Date |
---|---|
NO922447D0 NO922447D0 (en) | 1992-06-19 |
NO922447L true NO922447L (en) | 1992-08-19 |
Family
ID=27376503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92922447A NO922447L (en) | 1989-12-22 | 1992-06-19 | HYBRID MOLECULE WITH TRANSLOCATION REGION AND CELL BINDING REGION |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO922447L (en) |
-
1992
- 1992-06-19 NO NO92922447A patent/NO922447L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO922447D0 (en) | 1992-06-19 |
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