NO923415L - IMPROVED CHIMER TOXINS - Google Patents

IMPROVED CHIMER TOXINS

Info

Publication number
NO923415L
NO923415L NO92923415A NO923415A NO923415L NO 923415 L NO923415 L NO 923415L NO 92923415 A NO92923415 A NO 92923415A NO 923415 A NO923415 A NO 923415A NO 923415 L NO923415 L NO 923415L
Authority
NO
Norway
Prior art keywords
fragment
toxin
chimeric
chimeric toxin
missing
Prior art date
Application number
NO92923415A
Other languages
Norwegian (no)
Other versions
NO923415D0 (en
Inventor
Diane Williams
Original Assignee
Univ Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1991/001282 external-priority patent/WO1991013090A1/en
Application filed by Univ Hospital filed Critical Univ Hospital
Publication of NO923415D0 publication Critical patent/NO923415D0/en
Publication of NO923415L publication Critical patent/NO923415L/en

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  • Peptides Or Proteins (AREA)

Abstract

Et chimert toksin omfattende proteinfragmenter bundet sammen ved peptidbindinger, og det chimere toksinet består av, i rekkefolge, med start ved den aminoterminale enden av det chimere toksinet, (a) det enzymatisk aktive fragment A av difteritoksinet, (b) et første fragment som omfatter spaltningsområdet l, ved siden av difteritoksinets fragment A, (c) et annet fragment som omfatter minst en del av det hydrofobe transmembranområdet i difteritoksinets fragment B, det andre fragmentet mangler minst 50 difteritoksinaminosyre- rester, den manglende del er C-terminal for transmembran- området, og det andre fragmentet omfatter ikke område 1_, og (d) et tredje fragment omfattendeen del av en cellespesifikk polypeptidligand, idet delen omfatter minst en del av bindingsområdet til polypeptidliganden, og delen av bindings- området medfører at det chimere toksinet binder selektivt til en på forhånd bestemt klasse celler som skal angripes av det enzymatisk aktive fragment A.A chimeric toxin comprising protein fragments bound by peptide bonds, and the chimeric toxin consists, in sequence, starting at the amino-terminal end of the chimeric toxin, (a) the enzymatically active fragment A of the diphtheria toxin, (b) a first fragment comprising (c) another fragment comprising at least a portion of the hydrophobic transmembrane region of diphtheria toxin fragment B, the second fragment missing at least 50 diphtheria toxin amino acid residues, the missing portion being the C-terminal of the transmembrane membrane. and (d) a third fragment comprising a portion of a cell-specific polypeptide ligand, the portion comprising at least a portion of the binding region of the polypeptide ligand, and the portion of the binding region causing the chimeric toxin to selectively bind to a predetermined class of cells to be attacked by the enzymatically active fragment A.

NO92923415A 1990-03-02 1992-09-01 IMPROVED CHIMER TOXINS NO923415L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48860890A 1990-03-02 1990-03-02
US53743090A 1990-06-13 1990-06-13
PCT/US1991/001282 WO1991013090A1 (en) 1990-03-02 1991-02-28 Improved chimeric toxins

Publications (2)

Publication Number Publication Date
NO923415D0 NO923415D0 (en) 1992-09-01
NO923415L true NO923415L (en) 1992-10-30

Family

ID=27376726

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92923415A NO923415L (en) 1990-03-02 1992-09-01 IMPROVED CHIMER TOXINS

Country Status (1)

Country Link
NO (1) NO923415L (en)

Also Published As

Publication number Publication date
NO923415D0 (en) 1992-09-01

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