NO923415L - IMPROVED CHIMER TOXINS - Google Patents
IMPROVED CHIMER TOXINSInfo
- Publication number
- NO923415L NO923415L NO92923415A NO923415A NO923415L NO 923415 L NO923415 L NO 923415L NO 92923415 A NO92923415 A NO 92923415A NO 923415 A NO923415 A NO 923415A NO 923415 L NO923415 L NO 923415L
- Authority
- NO
- Norway
- Prior art keywords
- fragment
- toxin
- chimeric
- chimeric toxin
- missing
- Prior art date
Links
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Et chimert toksin omfattende proteinfragmenter bundet sammen ved peptidbindinger, og det chimere toksinet består av, i rekkefolge, med start ved den aminoterminale enden av det chimere toksinet, (a) det enzymatisk aktive fragment A av difteritoksinet, (b) et første fragment som omfatter spaltningsområdet l, ved siden av difteritoksinets fragment A, (c) et annet fragment som omfatter minst en del av det hydrofobe transmembranområdet i difteritoksinets fragment B, det andre fragmentet mangler minst 50 difteritoksinaminosyre- rester, den manglende del er C-terminal for transmembran- området, og det andre fragmentet omfatter ikke område 1_, og (d) et tredje fragment omfattendeen del av en cellespesifikk polypeptidligand, idet delen omfatter minst en del av bindingsområdet til polypeptidliganden, og delen av bindings- området medfører at det chimere toksinet binder selektivt til en på forhånd bestemt klasse celler som skal angripes av det enzymatisk aktive fragment A.A chimeric toxin comprising protein fragments bound by peptide bonds, and the chimeric toxin consists, in sequence, starting at the amino-terminal end of the chimeric toxin, (a) the enzymatically active fragment A of the diphtheria toxin, (b) a first fragment comprising (c) another fragment comprising at least a portion of the hydrophobic transmembrane region of diphtheria toxin fragment B, the second fragment missing at least 50 diphtheria toxin amino acid residues, the missing portion being the C-terminal of the transmembrane membrane. and (d) a third fragment comprising a portion of a cell-specific polypeptide ligand, the portion comprising at least a portion of the binding region of the polypeptide ligand, and the portion of the binding region causing the chimeric toxin to selectively bind to a predetermined class of cells to be attacked by the enzymatically active fragment A.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48860890A | 1990-03-02 | 1990-03-02 | |
US53743090A | 1990-06-13 | 1990-06-13 | |
PCT/US1991/001282 WO1991013090A1 (en) | 1990-03-02 | 1991-02-28 | Improved chimeric toxins |
Publications (2)
Publication Number | Publication Date |
---|---|
NO923415D0 NO923415D0 (en) | 1992-09-01 |
NO923415L true NO923415L (en) | 1992-10-30 |
Family
ID=27376726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO92923415A NO923415L (en) | 1990-03-02 | 1992-09-01 | IMPROVED CHIMER TOXINS |
Country Status (1)
Country | Link |
---|---|
NO (1) | NO923415L (en) |
-
1992
- 1992-09-01 NO NO92923415A patent/NO923415L/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO923415D0 (en) | 1992-09-01 |
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