NO913119L - STABILIZATION OF K1K2P PRO. - Google Patents

STABILIZATION OF K1K2P PRO.

Info

Publication number
NO913119L
NO913119L NO91913119A NO913119A NO913119L NO 913119 L NO913119 L NO 913119L NO 91913119 A NO91913119 A NO 91913119A NO 913119 A NO913119 A NO 913119A NO 913119 L NO913119 L NO 913119L
Authority
NO
Norway
Prior art keywords
derivative
pro
k1k2p pro
k1k2p
relates
Prior art date
Application number
NO91913119A
Other languages
Norwegian (no)
Other versions
NO913119D0 (en
NO305584B1 (en
Inventor
Ulrich Kohnert
Rainer Rudolph
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Publication of NO913119D0 publication Critical patent/NO913119D0/en
Publication of NO913119L publication Critical patent/NO913119L/en
Publication of NO305584B1 publication Critical patent/NO305584B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention relates to a pharmaceutical preparation of a non-glycosylized t-PA derivative, K1K2P pro, with an enzymatic activity of at least 0.4 MU/ml and a pH of 4.5 to 6, containing citrate and at least one compound from the following group: a) ascorbic acid, b) EDTA, c) amino compounds of formula R?1R?2N -R - X, where X = SO3?H, CH(NH2?)-CO2?H, CO2?H, H, NH2? or OH, R = C1?-C9? alkylene, C3?-C6? cycloalkylene or benzylidene and R?1 and R?2, independently of each other, are H or C1?-C3? alkyl, d) guianidinobutyric acid, e) dimethylbiguanide, f) arginine, g) glucosamine, fructose, h) pyrimidine nucleosides and pyrimidine nucleotides, i) carboxylic acids substituted with one or more hydroxyl, keto and/or further carboxyl groups. The invention also relates to a drug containing the t-PA derivative K1K2P pro as the active ingredient and a process for producing it.
NO913119A 1989-12-20 1991-08-09 Process for preparing a pharmaceutical surface preparation of a non-glycosylated t-PA derivative K1K2P pro NO305584B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3942144A DE3942144A1 (en) 1989-12-20 1989-12-20 STABILIZATION OF K1K2P PRO
PCT/EP1990/002248 WO1991008763A1 (en) 1989-12-20 1990-12-19 Stabilization of k1k2p pro

Publications (3)

Publication Number Publication Date
NO913119D0 NO913119D0 (en) 1991-08-09
NO913119L true NO913119L (en) 1991-08-09
NO305584B1 NO305584B1 (en) 1999-06-28

Family

ID=6395927

Family Applications (1)

Application Number Title Priority Date Filing Date
NO913119A NO305584B1 (en) 1989-12-20 1991-08-09 Process for preparing a pharmaceutical surface preparation of a non-glycosylated t-PA derivative K1K2P pro

Country Status (13)

Country Link
EP (1) EP0458949B1 (en)
JP (1) JPH0657662B2 (en)
KR (1) KR920700685A (en)
AT (1) ATE121948T1 (en)
AU (1) AU624761B2 (en)
CA (1) CA2046930C (en)
DE (2) DE3942144A1 (en)
DK (1) DK0458949T3 (en)
ES (1) ES2071978T3 (en)
FI (1) FI98601C (en)
HU (2) HUT59611A (en)
NO (1) NO305584B1 (en)
WO (1) WO1991008763A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3942141A1 (en) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh K2P PRO STABILIZATION
JP3368282B2 (en) * 1992-04-30 2003-01-20 ミレニアム ファーマシューティカルズ，インコーポレイティド Stable polypeptide composition
DE4405426A1 (en) * 1994-02-21 1995-08-24 Boehringer Mannheim Gmbh Pharmaceutical preparation containing plasminogen activator (t-PA) or its derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
DE3718889A1 (en) * 1987-06-05 1988-12-22 Behringwerke Ag METHOD FOR PRODUCING A SOLUTION OF HIGH SPECIFIC VOLUME ACTIVITY FROM A PROTEIN WITH TISSUE PLASMINOGEN ACTIVATOR (T-PA) ACTIVITY, SOLUTION, CONTAINING PROTEIN WITH T-PA ACTIVITY AND USE OF THE SOLUTION AND IN THE HUMAN VITALIZE
DE3923339A1 (en) * 1989-05-31 1990-12-06 Boehringer Mannheim Gmbh FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE

Also Published As

Publication number Publication date
NO913119D0 (en) 1991-08-09
FI913906A0 (en) 1991-08-19
ES2071978T3 (en) 1995-07-01
EP0458949A1 (en) 1991-12-04
KR920700685A (en) 1992-08-10
FI98601C (en) 1997-07-25
AU7046191A (en) 1991-07-18
DE59009025D1 (en) 1995-06-08
CA2046930C (en) 1997-01-14
FI98601B (en) 1997-04-15
DE3942144A1 (en) 1991-06-27
ATE121948T1 (en) 1995-05-15
CA2046930A1 (en) 1991-06-21
HUT59611A (en) 1992-06-29
JPH04502606A (en) 1992-05-14
HU912741D0 (en) 1992-01-28
NO305584B1 (en) 1999-06-28
HU208638B (en) 1993-12-28
WO1991008763A1 (en) 1991-06-27
JPH0657662B2 (en) 1994-08-03
AU624761B2 (en) 1992-06-18
DK0458949T3 (en) 1995-10-02
EP0458949B1 (en) 1995-05-03

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MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN JUNE 2003