EA199600104A1 - Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives - Google Patents

Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives

Info

Publication number
EA199600104A1
EA199600104A1 EA199600104A EA199600104A EA199600104A1 EA 199600104 A1 EA199600104 A1 EA 199600104A1 EA 199600104 A EA199600104 A EA 199600104A EA 199600104 A EA199600104 A EA 199600104A EA 199600104 A1 EA199600104 A1 EA 199600104A1
Authority
EA
Eurasian Patent Office
Prior art keywords
biologically active
polypyrrolecarboxamidonaphthalene
linking
derivatives
active compounds
Prior art date
Application number
EA199600104A
Other languages
Russian (ru)
Other versions
EA000006B1 (en
Inventor
Никола Монджелли
Джиованни Бьясолли
Андреа Ломбарди Борджиа
Марина Чомей
Энрико Пезенци
Францеско Анджелуччи
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199600104A1 publication Critical patent/EA199600104A1/en
Publication of EA000006B1 publication Critical patent/EA000006B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Предложено соединение формулы (II)где R является кислотной группой; m есть целое число от 1 до 3; n равен 0 или целому числу от 1 до 3; A представляет собой ферментативно гидролизуемый спейсер; X является биологически активным соединением; или его фармацевтически приемлемая соль, для использования в качестве противопролиферативного, в частности противоопухолевого и противоангиогенного средства, и в качестве противовоспалительного средства.The proposed compound of formula (II) where R is an acid group; m is an integer from 1 to 3; n is 0 or an integer from 1 to 3; A is an enzymatically hydrolyzable spacer; X is a biologically active compound; or a pharmaceutically acceptable salt thereof, for use as an anti-proliferative, in particular anti-tumor and anti-angiogenic agent, and as an anti-inflammatory agent.

EA199600104A 1995-03-01 1996-02-08 Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives EA000006B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9504065.5A GB9504065D0 (en) 1995-03-01 1995-03-01 Poly-pyrrolecarboxamidonaphthalenic acid derivatives
PCT/EP1996/000528 WO1996026950A1 (en) 1995-03-01 1996-02-08 Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives

Publications (2)

Publication Number Publication Date
EA199600104A1 true EA199600104A1 (en) 1997-09-30
EA000006B1 EA000006B1 (en) 1997-12-30

Family

ID=10770421

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199600104A EA000006B1 (en) 1995-03-01 1996-02-08 Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives

Country Status (18)

Country Link
EP (1) EP0758339A1 (en)
JP (1) JPH10504319A (en)
KR (1) KR970702868A (en)
CN (1) CN1148391A (en)
AR (1) AR002280A1 (en)
AU (1) AU696470B2 (en)
CA (1) CA2189358A1 (en)
EA (1) EA000006B1 (en)
FI (1) FI964331A (en)
GB (1) GB9504065D0 (en)
HU (1) HUP9603305A3 (en)
IL (1) IL117193A0 (en)
MX (1) MX9605089A (en)
NO (1) NO964610D0 (en)
NZ (1) NZ302267A (en)
PL (1) PL317094A1 (en)
WO (1) WO1996026950A1 (en)
ZA (1) ZA961636B (en)

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ATE210673T1 (en) * 1996-09-30 2001-12-15 Bayer Ag GLYCOCONJUGATES OF MODIFIED CAMPTOTHECINE DERIVATIVES (20-O LINKAGE)
DE19640969A1 (en) * 1996-10-04 1998-04-16 Bayer Ag 20-0 linked glycoconjugates from camptothecin
ID23424A (en) * 1997-05-14 2000-04-20 Bayer Ag GLIKOKONJUGUS OF 20 (S) -CAMPTOTESIN
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
US6485514B1 (en) * 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6777425B2 (en) 2001-06-13 2004-08-17 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
US7060685B2 (en) * 2002-05-16 2006-06-13 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
AU2003243380A1 (en) 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
EP1539151B1 (en) 2002-08-02 2009-03-18 Genesoft Pharmaceuticals, Inc. Biaryl compounds having anti-infective activity
WO2004039318A2 (en) 2002-10-25 2004-05-13 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
EP1587529A4 (en) 2002-12-10 2009-08-12 Oscient Pharmaceuticals Corp Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
LT2264043T (en) 2005-09-02 2017-12-11 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
US7875602B2 (en) 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
EP2585096B1 (en) * 2010-06-24 2021-05-05 University Of Kansas Bifunctional conjugate compositions and associated methods
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
AU2012358150B2 (en) 2011-12-22 2017-07-20 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
CN104837492B (en) 2012-12-07 2018-04-27 糖模拟物有限公司 Use compound, composition and the method for E-Selectin antagonist mobilizing hematopoietic cell
EP3227310B1 (en) 2014-12-03 2019-07-31 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
JP2019524791A (en) 2016-08-08 2019-09-05 グリコミメティクス， インコーポレイテッド Combinations of T cell checkpoint inhibitors with inhibitors of E-selectin or inhibitors of CXCR4 or with heterobifunctional inhibitors of both E-selectin and CXCR4
US11072625B2 (en) 2016-10-07 2021-07-27 Glycomimetics, Inc. Highly potent multimeric e-selectin antagonists
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
EP3732186A1 (en) 2017-12-29 2020-11-04 GlycoMimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
EP3761994A1 (en) 2018-03-05 2021-01-13 GlycoMimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
WO2021118927A1 (en) 2019-12-13 2021-06-17 Insideoutbio, Inc. Methods and compositions for targeted delivery of nucleic acid therapeutics
CN114933569B (en) * 2022-04-07 2024-07-23 澳门科技大学 Sphingolipid compound, liposome containing sphingolipid compound and application

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GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation

Also Published As

Publication number Publication date
JPH10504319A (en) 1998-04-28
AR002280A1 (en) 1998-03-11
AU696470B2 (en) 1998-09-10
ZA961636B (en) 1996-09-06
CA2189358A1 (en) 1996-09-06
EA000006B1 (en) 1997-12-30
IL117193A0 (en) 1996-06-18
CN1148391A (en) 1997-04-23
NO964610L (en) 1996-10-31
FI964331A (en) 1996-11-01
FI964331A0 (en) 1996-10-28
PL317094A1 (en) 1997-03-17
NZ302267A (en) 1997-10-24
AU4869896A (en) 1996-09-18
NO964610D0 (en) 1996-10-31
KR970702868A (en) 1997-06-10
HUP9603305A3 (en) 1998-01-28
EP0758339A1 (en) 1997-02-19
WO1996026950A1 (en) 1996-09-06
HUP9603305A2 (en) 1997-08-28
GB9504065D0 (en) 1995-04-19
MX9605089A (en) 1997-12-31

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ RU

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ KG TJ TM