NO964610L - Increased bioavailability of biologically active compounds by binding to polypyrrole carboxamidone offset derivatives - Google Patents

Increased bioavailability of biologically active compounds by binding to polypyrrole carboxamidone offset derivatives

Info

Publication number
NO964610L
NO964610L NO964610A NO964610A NO964610L NO 964610 L NO964610 L NO 964610L NO 964610 A NO964610 A NO 964610A NO 964610 A NO964610 A NO 964610A NO 964610 L NO964610 L NO 964610L
Authority
NO
Norway
Prior art keywords
biologically active
carboxamidone
polypyrrole
binding
active compounds
Prior art date
Application number
NO964610A
Other languages
Norwegian (no)
Other versions
NO964610D0 (en
Inventor
Nicola Mongelli
Andrea Lomdardi Borgia
Enrico Pesenti
Giovanni Biasoli
Marina Ciomei
Francesco Angelicci
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of NO964610D0 publication Critical patent/NO964610D0/en
Publication of NO964610L publication Critical patent/NO964610L/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

Forbindelse av formel (II) NH--CO¿A-X --CO- N CH, (II) hvor R er en sur gruppe; m er et helt tall fra l til 3; n er O eller et helt tall fra l til 3; A er en enzymatisk hydrolyserbar avstandsgruppe; og X er en biologisk aktiv forbindelse; eller et farmasøytisk akseptabelt salt derav, for bruk som et antiproliferativ, spesielt anti-tumor- og anti-angiogent middel, og anti-inflammatorisk middel.Compound of formula (II) NH - CO COA-X - CO- N CH, (II) wherein R is an acidic group; m is an integer from 1 to 3; n is 0 or an integer from 1 to 3; A is an enzymatic hydrolyzable spacer; and X is a biologically active compound; or a pharmaceutically acceptable salt thereof, for use as an antiproliferative, especially anti-tumor and anti-angiogenic agent, and anti-inflammatory agent.

NO964610A 1995-03-01 1996-10-31 Increased bioavailability of biologically active compounds by binding to polypyrrole carboxamidone offset derivatives NO964610L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9504065.5A GB9504065D0 (en) 1995-03-01 1995-03-01 Poly-pyrrolecarboxamidonaphthalenic acid derivatives
PCT/EP1996/000528 WO1996026950A1 (en) 1995-03-01 1996-02-08 Increased bioavailability of biologically active compounds by linking to polypyrrolecarboxamidonaphthalene derivatives

Publications (2)

Publication Number Publication Date
NO964610D0 NO964610D0 (en) 1996-10-31
NO964610L true NO964610L (en) 1996-10-31

Family

ID=10770421

Family Applications (1)

Application Number Title Priority Date Filing Date
NO964610A NO964610L (en) 1995-03-01 1996-10-31 Increased bioavailability of biologically active compounds by binding to polypyrrole carboxamidone offset derivatives

Country Status (18)

Country Link
EP (1) EP0758339A1 (en)
JP (1) JPH10504319A (en)
KR (1) KR970702868A (en)
CN (1) CN1148391A (en)
AR (1) AR002280A1 (en)
AU (1) AU696470B2 (en)
CA (1) CA2189358A1 (en)
EA (1) EA000006B1 (en)
FI (1) FI964331A (en)
GB (1) GB9504065D0 (en)
HU (1) HUP9603305A3 (en)
IL (1) IL117193A0 (en)
MX (1) MX9605089A (en)
NO (1) NO964610L (en)
NZ (1) NZ302267A (en)
PL (1) PL317094A1 (en)
WO (1) WO1996026950A1 (en)
ZA (1) ZA961636B (en)

Families Citing this family (36)

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Publication number Priority date Publication date Assignee Title
PT934329E (en) * 1996-09-30 2002-05-31 Bayer Ag GLYCOCONYGATES OF MODIFIED CAMPTOTECIN DERIVATIVES (LIGACAO 20-O)
DE19640969A1 (en) * 1996-10-04 1998-04-16 Bayer Ag 20-0 linked glycoconjugates from camptothecin
ID23424A (en) * 1997-05-14 2000-04-20 Bayer Ag GLIKOKONJUGUS OF 20 (S) -CAMPTOTESIN
GB9713732D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Substituted triazinic compounds
GB9713733D0 (en) * 1997-06-27 1997-09-03 Pharmacia & Upjohn Spa Poly-branched polycarboxamido compounds
US6485514B1 (en) * 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
US6288072B1 (en) * 1999-12-29 2001-09-11 Monroe E. Wall Camptothecin β-alanine esters with topoisomerase I inhibition
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
WO2002100832A1 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Isoquinoline compounds having antiinfective activity
WO2003097658A2 (en) * 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
WO2003101998A1 (en) 2002-06-03 2003-12-11 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
DE60326735D1 (en) 2002-08-02 2009-04-30 Genesoft Pharmaceuticals Inc BIARYL COMPOUNDS WITH ANTI-INFECTIVE EFFECT
US7265129B2 (en) 2002-10-25 2007-09-04 Genesoft Pharmaceuticals, Inc. Anti-infective biaryl compounds
EP1587529A4 (en) 2002-12-10 2009-08-12 Oscient Pharmaceuticals Corp Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
ES2651929T3 (en) 2005-09-02 2018-01-30 Glycomimetics, Inc. Heterobifunctional pan-selectin inhibitors
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
WO2009126556A1 (en) 2008-04-08 2009-10-15 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
EP2585096B1 (en) * 2010-06-24 2021-05-05 University Of Kansas Bifunctional conjugate compositions and associated methods
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
KR102055958B1 (en) 2011-12-22 2019-12-13 글리코미메틱스, 인크. E-selectin antagonist compounds, compositions, and methods of use
SI2928476T1 (en) 2012-12-07 2018-06-29 Glycomimetics, Inc. Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells
PT3227310T (en) 2014-12-03 2019-11-06 Glycomimetics Inc Heterobifunctional inhibitors of e-selectins and cxcr4 chemokine receptors
WO2017127422A1 (en) 2016-01-22 2017-07-27 Glycomimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
JP2019524791A (en) 2016-08-08 2019-09-05 グリコミメティクス， インコーポレイテッド Combinations of T cell checkpoint inhibitors with inhibitors of E-selectin or inhibitors of CXCR4 or with heterobifunctional inhibitors of both E-selectin and CXCR4
BR112019006642A2 (en) 2016-10-07 2019-07-02 Glycomimetics Inc highly potent multimeric e-selectin antagonists
EP3596096A1 (en) 2017-03-15 2020-01-22 GlycoMimetics, Inc. Galactopyranosyl-cyclohexyl derivatives as e-selectin antagonists
EP3381897A1 (en) 2017-03-27 2018-10-03 Leadiant Biosciences SA Derivatives of the disodium 2,2'-{carbonylbis[imino-3,1-phenylenecarbonylimino(1-methyl-1h-pyrrole-4,2-diyl)carbonylimino]}dinaphthalene-1,5-disulfonate salt and related compounds as heparanase inhibitors for the treatment of cancer
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
KR20200104889A (en) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-selectin and heterobifunctional inhibitors of galectin-3
WO2019173229A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
WO2021118927A1 (en) 2019-12-13 2021-06-17 Insideoutbio, Inc. Methods and compositions for targeted delivery of nucleic acid therapeutics
CN114933569B (en) * 2022-04-07 2024-07-23 澳门科技大学 Sphingolipid compound, liposome containing sphingolipid compound and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9304589D0 (en) * 1993-03-05 1993-04-21 Erba Carlo Spa Biologically active ureido derivatives useful as antimetastic agents
GB9307948D0 (en) * 1993-04-16 1993-06-02 Erba Carlo Spa Biologically active ureido derivatives useful in the treatment of lentivirus-induced disease
GB9403909D0 (en) * 1994-03-01 1994-04-20 Erba Carlo Spa Ureido derivatives of naphthalenephosphonic acids and process for their preparation

Also Published As

Publication number Publication date
NZ302267A (en) 1997-10-24
AU696470B2 (en) 1998-09-10
HUP9603305A3 (en) 1998-01-28
NO964610D0 (en) 1996-10-31
FI964331A0 (en) 1996-10-28
CA2189358A1 (en) 1996-09-06
ZA961636B (en) 1996-09-06
HUP9603305A2 (en) 1997-08-28
AU4869896A (en) 1996-09-18
EP0758339A1 (en) 1997-02-19
KR970702868A (en) 1997-06-10
CN1148391A (en) 1997-04-23
EA199600104A1 (en) 1997-09-30
FI964331A (en) 1996-11-01
WO1996026950A1 (en) 1996-09-06
IL117193A0 (en) 1996-06-18
MX9605089A (en) 1997-12-31
GB9504065D0 (en) 1995-04-19
EA000006B1 (en) 1997-12-30
AR002280A1 (en) 1998-03-11
JPH10504319A (en) 1998-04-28
PL317094A1 (en) 1997-03-17

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