NO912979L - Fremgangsmaate for fremstilling av 2-(9-fluorenoyl)-carbapenederivater. - Google Patents

Fremgangsmaate for fremstilling av 2-(9-fluorenoyl)-carbapenederivater.

Info

Publication number
NO912979L
NO912979L NO91912979A NO912979A NO912979L NO 912979 L NO912979 L NO 912979L NO 91912979 A NO91912979 A NO 91912979A NO 912979 A NO912979 A NO 912979A NO 912979 L NO912979 L NO 912979L
Authority
NO
Norway
Prior art keywords
fluorenoyl
carbapene
derivatives
procedure
preparation
Prior art date
Application number
NO91912979A
Other languages
English (en)
Other versions
NO912979D0 (no
Inventor
Mark L Greenlee
Frank P Dininno
Lovji D Cama
James V Heck
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/561,541 external-priority patent/US5025007A/en
Priority claimed from US07/594,809 external-priority patent/US5144028A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO912979D0 publication Critical patent/NO912979D0/no
Publication of NO912979L publication Critical patent/NO912979L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO91912979A 1990-08-01 1991-07-31 Fremgangsmaate for fremstilling av 2-(9-fluorenoyl)-carbapenederivater. NO912979L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/561,541 US5025007A (en) 1990-08-01 1990-08-01 2-(9-fluorenonyl)-carbapenem antibacterial agents
US07/594,809 US5144028A (en) 1990-10-09 1990-10-09 2-(9-fluorenonyl)-carbapenem intermediates

Publications (2)

Publication Number Publication Date
NO912979D0 NO912979D0 (no) 1991-07-31
NO912979L true NO912979L (no) 1992-02-03

Family

ID=27072673

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91912979A NO912979L (no) 1990-08-01 1991-07-31 Fremgangsmaate for fremstilling av 2-(9-fluorenoyl)-carbapenederivater.

Country Status (12)

Country Link
EP (1) EP0469844A1 (no)
JP (1) JPH0798821B2 (no)
KR (1) KR920004389A (no)
AU (1) AU643308B2 (no)
CA (1) CA2048279A1 (no)
FI (1) FI913654A (no)
IE (1) IE912708A1 (no)
IL (1) IL99011A0 (no)
MX (1) MX9100467A (no)
NO (1) NO912979L (no)
NZ (1) NZ239187A (no)
PT (1) PT98521A (no)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE172956T1 (de) * 1993-06-18 1998-11-15 Otsuka Pharma Co Ltd Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen
US5451579A (en) * 1994-02-15 1995-09-19 Merck & Co., Inc. 1-β-methyl-carbapenem, compositions containing same and methods of use
US20070265242A1 (en) * 2004-09-03 2007-11-15 Makoto Sunagawa Novel Carbapenem Compound
EP2135871A1 (en) * 2008-06-18 2009-12-23 LEK Pharmaceuticals D.D. New trinem antibiotics and inhibitors of beta-lactamases
ES2926800T3 (es) 2010-07-08 2022-10-28 Hans Rudolf Pfaendler Carbapenem fluorescentes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4543257A (en) * 1977-10-19 1985-09-24 Merck & Co., Inc. 1-Carba-2-penem-3-carboxylic acid
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
US4600713A (en) * 1979-12-03 1986-07-15 Merck & Co., Inc. 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids
EP0277743A1 (en) * 1987-02-02 1988-08-10 Merck & Co. Inc. 2-(heteroaryliumalkyl)phenyl carbapenem antibacterial agents
US5025008A (en) * 1989-06-08 1991-06-18 Merck & Co., Inc. 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents

Also Published As

Publication number Publication date
KR920004389A (ko) 1992-03-27
IL99011A0 (en) 1992-07-15
PT98521A (pt) 1992-06-30
NZ239187A (en) 1993-10-26
AU8151891A (en) 1992-02-06
FI913654A (fi) 1992-02-02
JPH05105681A (ja) 1993-04-27
FI913654A0 (fi) 1991-07-31
CA2048279A1 (en) 1992-02-02
MX9100467A (es) 1992-04-01
IE912708A1 (en) 1992-02-12
EP0469844A1 (en) 1992-02-05
JPH0798821B2 (ja) 1995-10-25
NO912979D0 (no) 1991-07-31
AU643308B2 (en) 1993-11-11

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