NO903667L - Forbedret fremgangsmaate for fremstilling av trans-6-(2-(substituert-pyrrol-yl)alkyl)pyran-2-on inhibitorer for kolesterolsyntese. - Google Patents

Forbedret fremgangsmaate for fremstilling av trans-6-(2-(substituert-pyrrol-yl)alkyl)pyran-2-on inhibitorer for kolesterolsyntese.

Info

Publication number
NO903667L
NO903667L NO90903667A NO903667A NO903667L NO 903667 L NO903667 L NO 903667L NO 90903667 A NO90903667 A NO 90903667A NO 903667 A NO903667 A NO 903667A NO 903667 L NO903667 L NO 903667L
Authority
NO
Norway
Prior art keywords
pyrrol
pyran
inhibitors
substituted
alkyl
Prior art date
Application number
NO90903667A
Other languages
English (en)
Other versions
NO177566B (no
NO903667D0 (no
NO177566C (no
Inventor
Donald Eugene Butler
Carl Francis Deering
Alan Millar
Thomas Norman Nanninga
Bruce David Roth
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27376115&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO903667(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/303,733 external-priority patent/US5003080A/en
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO903667D0 publication Critical patent/NO903667D0/no
Publication of NO903667L publication Critical patent/NO903667L/no
Priority to NO941725A priority Critical patent/NO177706C/no
Priority to NO943057A priority patent/NO177423C/no
Priority to NO951075A priority patent/NO180119C/no
Publication of NO177566B publication Critical patent/NO177566B/no
Publication of NO177566C publication Critical patent/NO177566C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/80—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms having carbon atoms of carboxamide groups and keto groups bound to the same carbon atom, e.g. acetoacetamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO903667A 1988-02-22 1990-08-21 Nye 1,3-dioksan-derivater NO177566C (no)

Priority Applications (3)

Application Number Priority Date Filing Date Title
NO941725A NO177706C (no) 1988-02-22 1994-05-09 Forbedret fremgangsmåte for fremstilling av trans-6-[2- (substituert-pyrrol-yl) alkylÅ pyran-2-on-inhibitorer for kolesterolsyntese
NO943057A NO177423C (no) 1988-02-22 1994-08-18 Forbedret fremgangsmåte for fremstilling av trans-6-[2-(substituert-pyrrol-yl)alkylÅpyran-2-on-inhibitorer for kolesterolsyntese
NO951075A NO180119C (no) 1988-02-22 1995-03-21 Utgangsmaterialer for fremstilling av trans-6-£2-(substituert-pyrrol-yl)alkyl|pyran-2-on-inhibitorer for kolesterolsyntese

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15843988A 1988-02-22 1988-02-22
US07/303,733 US5003080A (en) 1988-02-22 1989-02-01 Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
PCT/US1989/000719 WO1989007598A2 (en) 1988-02-22 1989-02-22 Improved process for trans-6-[2-(substituted-pyrrol-1-yl)alkyl]pyran-2-one inhibitors of cholesterol synthesis

Publications (4)

Publication Number Publication Date
NO903667D0 NO903667D0 (no) 1990-08-21
NO903667L true NO903667L (no) 1990-09-27
NO177566B NO177566B (no) 1995-07-03
NO177566C NO177566C (no) 1995-10-11

Family

ID=27376115

Family Applications (1)

Application Number Title Priority Date Filing Date
NO903667A NO177566C (no) 1988-02-22 1990-08-21 Nye 1,3-dioksan-derivater

Country Status (2)

Country Link
AU (1) AU621874B2 (no)
NO (1) NO177566C (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO881411L (no) * 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.
FI94339C (fi) * 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi

Also Published As

Publication number Publication date
NO177566B (no) 1995-07-03
NO903667D0 (no) 1990-08-21
AU621874B2 (en) 1992-03-26
AU3349689A (en) 1989-09-06
NO177566C (no) 1995-10-11

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