NO883614L - MOLECYCLES CLONING AND EXPRESSION OF HUMANT IL-3. - Google Patents

MOLECYCLES CLONING AND EXPRESSION OF HUMANT IL-3.

Info

Publication number
NO883614L
NO883614L NO88883614A NO883614A NO883614L NO 883614 L NO883614 L NO 883614L NO 88883614 A NO88883614 A NO 88883614A NO 883614 A NO883614 A NO 883614A NO 883614 L NO883614 L NO 883614L
Authority
NO
Norway
Prior art keywords
hil
expression
molecycles
humant
cloning
Prior art date
Application number
NO88883614A
Other languages
Norwegian (no)
Other versions
NO180544B (en
NO180544C (en
NO883614D0 (en
Inventor
Lambertus Christiaan Dorssers
Gerard Wagemaker
Yvonne Johanna Vos
Robert Willem Van Leen
Original Assignee
Gist Brocades Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv
Publication of NO883614D0 publication Critical patent/NO883614D0/en
Publication of NO883614L publication Critical patent/NO883614L/en
Publication of NO180544B publication Critical patent/NO180544B/en
Publication of NO180544C publication Critical patent/NO180544C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5403—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

A cDNA encoding human interleukin-3, also designated herein hIL-3 or hmulti-CSF, has been disposed in expression systems and caused to produce hIL-3 substantially free of impurities normally accompanying this protein as it is produced $i(inter alia) by peripheral blood lymphocytes in nature. The resulting hIL-3 can be produced in practical amounts and is useful in a variety of therapeutic and diagnostic protocols.
NO883614A 1986-12-16 1988-08-12 Process for Preparation of Human IL-3 (Pro-8), Expression Vector, Vector and Transformed Living Host Cell NO180544C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP86202285 1986-12-16
EP87201322 1987-07-13
PCT/NL1987/000037 WO1988004691A1 (en) 1986-12-16 1987-12-16 Molecular cloning and expression of human il-3

Publications (4)

Publication Number Publication Date
NO883614D0 NO883614D0 (en) 1988-08-12
NO883614L true NO883614L (en) 1988-08-12
NO180544B NO180544B (en) 1997-01-27
NO180544C NO180544C (en) 1997-05-07

Family

ID=26103432

Family Applications (1)

Application Number Title Priority Date Filing Date
NO883614A NO180544C (en) 1986-12-16 1988-08-12 Process for Preparation of Human IL-3 (Pro-8), Expression Vector, Vector and Transformed Living Host Cell

Country Status (14)

Country Link
JP (2) JPH01502157A (en)
AT (1) ATE161882T1 (en)
AU (1) AU617095B2 (en)
CA (1) CA1341503C (en)
DE (1) DE3752158T2 (en)
ES (1) ES2113338T3 (en)
FI (1) FI102293B1 (en)
GR (1) GR3025857T3 (en)
IE (1) IE81129B1 (en)
IL (1) IL84852A (en)
NO (1) NO180544C (en)
NZ (1) NZ222939A (en)
PT (1) PT86381B (en)
WO (1) WO1988004691A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors
US6238889B1 (en) 1986-12-16 2001-05-29 Dsm N.V. Molecular cloning and expression of the Pro8 isoform of human IL-3
OA09736A (en) * 1987-02-18 1993-11-30 Schering Biotech Corp "Human interleukin-3 and muteins thereof".
US5304637A (en) * 1987-07-13 1994-04-19 Gist-Brocades N.V. Expression and purification of human interleukin-3 and muteins thereof
GB2210883B (en) * 1987-10-08 1992-01-02 British Bio Technology Synthetic interleukin-3 gene
US6384194B1 (en) 1987-12-16 2002-05-07 Dsm N.V. Expression and purification of human interleukin-3 and muteins thereof
EP0425536A4 (en) * 1988-07-20 1992-01-02 Immunex Corporation Nonglycosylated human interleukin-3 compositions
NZ232913A (en) * 1989-03-15 1992-08-26 Gist Brocades Nv Il-3 produced recombinantly and purified to homogeneity; vectors and pharmaceutical preparations
US5128450A (en) * 1989-06-30 1992-07-07 Urdal David L Nonglycosylated human interleukin-3 analog proteins
US5516512A (en) 1989-08-14 1996-05-14 Gist-Brocades, N.V. N- and C-terminal truncation and deletion mutants of human interleukin-3
EP0810285A3 (en) 1989-08-14 1998-07-08 Gist-Brocades B.V. Mutants of human Interleukin-3
ES2100953T3 (en) * 1991-08-01 1997-07-01 Fond Nat Transfusion Sanguine EXPRESSION IN NON-TUMOR HUMAN LYMPHOBLASTOID LINES WITH AN INTEGRATING VECTOR.
US5738849A (en) * 1992-11-24 1998-04-14 G. D. Searle & Co. Interleukin-3 (IL-3) variant fusion proteins, their recombinant production, and therapeutic compositions comprising them
WO1994012639A2 (en) * 1992-11-24 1994-06-09 G. D. Searle & Co. Interleukin-3 (il-3) mutant polypeptides
US5501962A (en) * 1993-06-21 1996-03-26 G. D. Searle & Co. Interleuken-3 (IL-3) human/murine hybrid polypeptides and recombinant production of the same
US6017523A (en) * 1995-06-06 2000-01-25 G.D. Searle & Co. Therapeutic methods employing mutant human interleukin-3 (IL-3) polypeptides
WO1999041382A2 (en) * 1998-02-17 1999-08-19 Hyseq, Inc. A novel interleukin-3 and uses thereof
JP2008527981A (en) * 2005-01-25 2008-07-31 アポロ ライフ サイエンシズ リミテッド GM-CSF, IL-3, IL-4, IL-5, and chimeras thereof selected by parameters for therapeutic and diagnostic purposes
WO2007123689A1 (en) * 2006-04-03 2007-11-01 New England Biolabs, Inc. Expression, secretion and purification of recombinant bovine serum albumin (rbsa) and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695542A (en) * 1983-10-04 1987-09-22 Dnax Research Institute Of Molecular And Cellular Biology, Inc. cDNA clones coding for polypeptides exhibiting multi-lineage cellular growth factor activity
AU570762B2 (en) * 1983-12-23 1988-03-24 Australian National University, The Cloning of cdna for il-3
GR871029B (en) * 1986-07-14 1987-11-02 Genetics Inst Novel osteoinductive factors

Also Published As

Publication number Publication date
FI102293B (en) 1998-11-13
PT86381A (en) 1988-01-01
FI883688A (en) 1988-08-08
GR3025857T3 (en) 1998-04-30
NO180544B (en) 1997-01-27
NO180544C (en) 1997-05-07
ES2113338T3 (en) 1998-05-01
DE3752158D1 (en) 1998-02-12
PT86381B (en) 1990-11-20
JPH1080286A (en) 1998-03-31
IL84852A0 (en) 1988-06-30
AU617095B2 (en) 1991-11-21
AU1057788A (en) 1988-07-15
NZ222939A (en) 1991-03-26
NO883614D0 (en) 1988-08-12
FI102293B1 (en) 1998-11-13
IL84852A (en) 1994-06-24
FI883688A0 (en) 1988-08-08
IE873409L (en) 1988-06-12
JPH01502157A (en) 1989-08-03
WO1988004691A1 (en) 1988-06-30
CA1341503C (en) 2006-04-04
ATE161882T1 (en) 1998-01-15
DE3752158T2 (en) 1998-05-20
IE81129B1 (en) 2000-03-22

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Legal Events

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Free format text: LAPSED IN JUNE 2003