NO872581L - Et produksjon av antistoffer ved anvendelse av insolubil iserte immunkomplekser. - Google Patents
Et produksjon av antistoffer ved anvendelse av insolubil iserte immunkomplekser.Info
- Publication number
- NO872581L NO872581L NO872581A NO872581A NO872581L NO 872581 L NO872581 L NO 872581L NO 872581 A NO872581 A NO 872581A NO 872581 A NO872581 A NO 872581A NO 872581 L NO872581 L NO 872581L
- Authority
- NO
- Norway
- Prior art keywords
- insolubilized
- antibodies
- antigen
- immune complexes
- antibody
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- C07K16/4266—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig against anti-tumor receptor Ig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6056—Antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/622—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier non-covalent binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
En fremgangsmåte for forbedring av produksjon av antistoffer gjennom immunosering med insolubiliserte immunkomplekser er beskrevet. Renset antigen eller heterogene antigenblandinger kan kombineres med polyklonalt eller monoklonalt antistoff og det resulterende kompleks blir bundet til insolubilisert protein A for å danne insolubiliserte immunkomplekser. Fremgangsmåter for forbedring av immunogeniteten av et leselig antigen og for produksjon av monoklonale anti-idiotypiske antistoffer er også beskrevet. Monoklonale antistoffer som er spesifikke for en spesiell, ennå ugjenkjent epitop, kan produseres ved en annen beskrevet fremgangsmåte. Insolubiliserte immunkomplekser, som omfatter er.tigen cg antistoff som enten er direkte bandet tii sefarose -ll = r absorbert på insolubilisert protein A og iir.munosorbenter, so- omfatter antistoff absorbert på insolubilisert protein A, også beskrevet.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87682886A | 1986-06-20 | 1986-06-20 | |
US07/024,632 US4879225A (en) | 1986-06-20 | 1987-03-11 | Enhanced production of antibodies utilizing insolubilized immune complexes |
Publications (2)
Publication Number | Publication Date |
---|---|
NO872581D0 NO872581D0 (no) | 1987-06-19 |
NO872581L true NO872581L (no) | 1987-12-21 |
Family
ID=26698676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO872581A NO872581L (no) | 1986-06-20 | 1987-06-19 | Et produksjon av antistoffer ved anvendelse av insolubil iserte immunkomplekser. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4879225A (no) |
EP (1) | EP0251065A3 (no) |
JP (1) | JPS63258496A (no) |
CN (1) | CN87105716A (no) |
AU (1) | AU615628B2 (no) |
DK (1) | DK315187A (no) |
NO (1) | NO872581L (no) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3565289A (en) * | 1988-05-05 | 1989-11-29 | National Research Development Corporation | Immunogenic complex and its use in vaccination |
EP0529007A1 (en) | 1990-04-18 | 1993-03-03 | The Regents Of The University Of California | A 35kD TUMOR ASSOCIATED PROTEIN ANTIGEN: USES AND METHODS OF DETECTION |
US5723115A (en) * | 1991-05-02 | 1998-03-03 | W. Alton Jones Cell Science Center, Inc. | Inhibition of adipose tissue development and obesity |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5283066A (en) * | 1992-02-19 | 1994-02-01 | Development Center For Biotechnology | Method of stimulating an immune response by using a hapten |
CA2098960C (en) * | 1992-07-10 | 2004-11-02 | Richard Barner | Bio specifically recognizing surfaces on solid supports and method for their preparation |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
ES2355184T3 (es) | 1993-01-28 | 2011-03-23 | Boston Scientific Limited | Inhibidores terapéuticos de células de músculo liso vascular. |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US7611533B2 (en) | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
GB9606425D0 (en) * | 1996-03-27 | 1996-06-05 | Binding Site Ltd | Improvements in and relating to the production of antibodies and test kits incorporating antibodies |
US7361346B1 (en) * | 1996-05-15 | 2008-04-22 | Altarex Corp. | Therapeutic compositions that produce an immune response |
US8038994B2 (en) * | 1996-05-15 | 2011-10-18 | Quest Pharmatech Inc. | Combination therapy for treating disease |
US7318921B2 (en) * | 1996-05-15 | 2008-01-15 | Altarex Medical Corp. | Therapeutic compositions that alter the immune response |
US20080220012A1 (en) * | 1996-05-15 | 2008-09-11 | Ragupathy Madiyalakan | Therapeutic Compositions that alter the immune response |
US20060159688A1 (en) * | 1996-05-15 | 2006-07-20 | Ragupathy Madiyalakan | Method for diagnosing efficacy of xenotypic antibody therapy |
US6241985B1 (en) * | 1996-05-15 | 2001-06-05 | Altarex Corp. | Method and composition for reconforming multi-epitopic antigens to initiate an immune response |
WO1998043618A2 (en) | 1997-03-31 | 1998-10-08 | Neorx Corporation | Use of cytoskeletal inhibitors for the prevention of restenosis |
EP2386565A3 (en) | 1999-01-12 | 2013-11-20 | Cambridge Enterprise Ltd. | Compounds and methods to inhibit or augment an inflammatory response |
US7009040B2 (en) * | 2003-01-21 | 2006-03-07 | Arius Research, Inc. | Cancerous disease modifying antibodies |
US6613083B2 (en) | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
CA2481796A1 (en) * | 2002-04-11 | 2003-10-23 | Altarex Medical Corporation | Binding agents and their use in targeting tumor cells |
US7393531B2 (en) * | 2003-01-21 | 2008-07-01 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
US7468254B2 (en) * | 2003-01-21 | 2008-12-23 | Arius Research Inc. | Cytotoxicity mediation of cells evidencing surface expression of MCSP |
JP3600231B1 (ja) * | 2003-09-30 | 2004-12-15 | 森永製菓株式会社 | イムノアッセイ |
WO2019199918A1 (en) * | 2018-04-11 | 2019-10-17 | Cowan Fred M | Compositions and methods for prevention and treatment of immune complex disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3063736D1 (en) * | 1979-03-27 | 1983-07-21 | Nat Res Dev | Improvements in or relating to immunological preparations |
IL63220A (en) * | 1981-07-01 | 1985-09-29 | Yeda Res & Dev | Process for production of polyacrolein microspheres |
US4471058A (en) * | 1982-07-26 | 1984-09-11 | Board Of Trustees Operating Michigan State University | Method for the detection and/or determination of a polyvalent antigen using at least two different monoclonal antibodies |
US4693966A (en) * | 1983-03-11 | 1987-09-15 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies from lymphocytes of patients with malignant melanoma |
FR2558165B1 (fr) * | 1984-01-17 | 1986-07-04 | Anvar | Nouveaux conjugues d'oligo-muramylpeptides et compositions biologiques les contenant pour l'activation des macrophages |
-
1987
- 1987-03-11 US US07/024,632 patent/US4879225A/en not_active Expired - Fee Related
- 1987-06-19 NO NO872581A patent/NO872581L/no unknown
- 1987-06-19 EP EP87108792A patent/EP0251065A3/en not_active Ceased
- 1987-06-19 CN CN198787105716A patent/CN87105716A/zh active Pending
- 1987-06-19 AU AU74496/87A patent/AU615628B2/en not_active Ceased
- 1987-06-19 DK DK315187A patent/DK315187A/da not_active Application Discontinuation
- 1987-06-20 JP JP62152442A patent/JPS63258496A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0251065A2 (en) | 1988-01-07 |
CN87105716A (zh) | 1988-06-08 |
JPS63258496A (ja) | 1988-10-25 |
DK315187D0 (da) | 1987-06-19 |
NO872581D0 (no) | 1987-06-19 |
AU615628B2 (en) | 1991-10-10 |
DK315187A (da) | 1987-12-21 |
US4879225A (en) | 1989-11-07 |
AU7449687A (en) | 1987-12-24 |
EP0251065A3 (en) | 1989-08-30 |
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