NO871720L - OXYALKYL CELLULOSE-CONTAINING GEL MATERIAL. - Google Patents
OXYALKYL CELLULOSE-CONTAINING GEL MATERIAL.Info
- Publication number
- NO871720L NO871720L NO871720A NO871720A NO871720L NO 871720 L NO871720 L NO 871720L NO 871720 A NO871720 A NO 871720A NO 871720 A NO871720 A NO 871720A NO 871720 L NO871720 L NO 871720L
- Authority
- NO
- Norway
- Prior art keywords
- gel
- cellulose
- gel material
- containing gel
- active material
- Prior art date
Links
- 239000000463 material Substances 0.000 title description 5
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000012876 carrier material Substances 0.000 claims description 6
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims description 5
- 229920013820 alkyl cellulose Polymers 0.000 claims description 4
- 239000000499 gel Substances 0.000 description 17
- 239000000203 mixture Substances 0.000 description 11
- 239000011149 active material Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 5
- 230000000622 irritating effect Effects 0.000 description 5
- 239000000600 sorbitol Substances 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- -1 PHB ester Chemical class 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 229920002678 cellulose Polymers 0.000 description 3
- 235000010980 cellulose Nutrition 0.000 description 3
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- OYPRJOBELJOOCE-IGMARMGPSA-N Calcium-40 Chemical compound [40Ca] OYPRJOBELJOOCE-IGMARMGPSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 description 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
- 239000008252 pharmaceutical gel Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000000979 retarding effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Jellies, Jams, And Syrups (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Description
Foreliggende oppfinnelse gjelder vandige, farma-søytiske gelmaterialer for lokal bruk. The present invention relates to aqueous pharmaceutical gel materials for local use.
For utvikling av lokalt anvendbare gelmaterialerFor the development of locally applicable gel materials
for å fremme sårheling, er det viktig å ha et bærermateriale som utøver en positiv virkning på forløpet av sårheling, men ikke har noen fysiologisk irriterende effekt eller ikke har en retarderende effekt på helbredelsesprosessen. to promote wound healing, it is important to have a carrier material that exerts a positive effect on the course of wound healing, but does not have a physiologically irritating effect or does not have a retarding effect on the healing process.
Dette er ikke lett siden vevet i åpne sår er eks-tremt følsomt og også irriteres av ikke-aggressive fremmede materialer, som forsinker helbredelsesprosessen og forårsaker smerte hos pasientene. This is not easy since the tissue in open wounds is extremely sensitive and is also irritated by non-aggressive foreign materials, which delays the healing process and causes pain to the patients.
Det er et formål med foreliggende oppfinnelse å til-veiebringe et bærermateriale for lokale gelpreparater som It is an aim of the present invention to provide a carrier material for local gel preparations which
ikke utøver en irriterende effekt på skadet vev hos varm-blodige dyr og mennesker og således fremmer sårheling. does not exert an irritating effect on damaged tissue in warm-blooded animals and humans and thus promotes wound healing.
Det er nu funnet at hydroxyalkylcellulose utgjør et slikt bærermateriale som, i form av en vandig gelblanding (hydrogel), ikke utøver noen irriterende virkning på vev og, under visse omstendigheter, selv oppviser en helbredelses-fremmende effekt selv uten aktive materialer. It has now been found that hydroxyalkyl cellulose constitutes such a carrier material which, in the form of an aqueous gel mixture (hydrogel), exerts no irritating effect on tissue and, under certain circumstances, even exhibits a healing-promoting effect even without active materials.
Ifølge foreliggende oppfinnelse tilveiebringes således et farmasøytisk, vandig gelpreparat for lokal admini-strasjon som, som bærermateriale for et farmasøytisk aktivt materiale, inneholder en C^-Cg-alkylhydroxy-C-^-Cg-alkyl-cellulose eller en hydroxy-C^-Cg-alkylcellulose. According to the present invention, a pharmaceutical, aqueous gel preparation for local administration is thus provided which, as a carrier material for a pharmaceutical active material, contains a C₁-C₆-alkylhydroxy-C-₆-C₆-alkyl cellulose or a hydroxy-C₆- C 6 -alkyl cellulose.
Hydrogelen ifølge foreliggende oppfinnelse inneholder fortrinnsvis et helbredelses-fremmende, aktivt materiale som, i sin tur, ikke har en irriterende virkning på vev for ikke å oppheve fordelene ved bærermaterialet. The hydrogel according to the present invention preferably contains a healing-promoting active material which, in turn, does not have an irritating effect on tissue so as not to nullify the benefits of the carrier material.
Aktive materialblandinger ifølge DE patentActive material mixtures according to DE patent
3 416 777 er eksempelvis enestående egnet for dette formål, siden disse materialer i isotoniske preparater ikke bare har en virkning som i sterk grad hemmer sårhelbredelsen, men også på samme tid er forenelig med vevene uten noen irriterende virkning. 3 416 777 is, for example, uniquely suitable for this purpose, since these materials in isotonic preparations not only have an effect which strongly inhibits wound healing, but are also compatible with the tissues without any irritating effect.
Hydroxyalkylcelluloser skal forståes å være de celluloser som inneholder lavere alkylradikaler, dvs. de med opp til 4 og fortrinnsvis 1 eller 2 carbonatomer eller hydrogen- atomer og en lavere alkylradikal. Disse omfatter for eksempel methylhydroxymethylcellulose, methylhydroxypropyl-cellulose, butylhydroxymethylcellulose, ethylhydroxypropyl-cellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxybutylcellulose og methylhydroxyethylcellulose er foretrukket. Hydroxyalkylcelluloses shall be understood to be those celluloses which contain lower alkyl radicals, i.e. those with up to 4 and preferably 1 or 2 carbon atoms or hydrogen atoms and a lower alkyl radical. These include, for example, methylhydroxymethylcellulose, methylhydroxypropylcellulose, butylhydroxymethylcellulose, ethylhydroxypropylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxybutylcellulose and methylhydroxyethylcellulose are preferred.
Med celluloser skal det forståes de" som har et polymerisasjonstall på fra 120 til 1200, for eksempel slike som er kommersielt tilgjengelige under varenavnet "Tylose". Celluloses are to be understood as having a polymerization number of from 120 to 1200, for example those that are commercially available under the trade name "Tylose".
Disse danner klare geler med vann, kan belegges og, kan i en steril form som er så isotonisk som mulig, lett på-føres, sammen med passende doserte, aktive materialer, på såroverflater. These form clear gels with water, can be coated and, in a sterile form that is as isotonic as possible, can be easily applied, together with suitably dosed active materials, to wound surfaces.
Gelen kan fremstilles ved langsomt å innføre hydroxyalkylcellulosen i varmt vann under omrøring og tillate den å gelere inntil den er homogen. Midler for justering av den isotoniske tilstand, f.eks. natriumklorid, glycerol eller sorbitol, såvel som konserveringsmidler, f.eks. PBB-estere, kan på forhånd være tilsatt til vannet. The gel can be prepared by slowly introducing the hydroxyalkyl cellulose into hot water with stirring and allowing it to gel until it is homogeneous. Means for adjusting the isotonic state, e.g. sodium chloride, glycerol or sorbitol, as well as preservatives, e.g. PBB esters can be added to the water in advance.
Gelpreparatet kan vanligvis også blandes med andre blandinger, f.eks. olje-i-vann- eller vann-i-olje-emulsjoner, avhengig av bruksformålet, for å meddele en viss grad av lipofili til preparatene som kan hindre skorpedannelse på såroverflaten. The gel preparation can usually also be mixed with other mixtures, e.g. oil-in-water or water-in-oil emulsions, depending on the purpose of use, to impart a certain degree of lipophilicity to the preparations that can prevent crusting on the wound surface.
Ved fremstilling av gelpreparatet må det også ut-vises forsiktighet slik at et pH-område som er fordelaktig for sårhelbredelse på ca. 3,5 til 7,5 og fortrinnsvis fra 4 til 7 ikke underskrides eller overstiges. I forforsøk er det påvist at en sorbitol-holdig gel med pH på 4 er meget lett forenelig. When preparing the gel preparation, care must also be taken so that a pH range that is beneficial for wound healing of approx. 3.5 to 7.5 and preferably from 4 to 7 is not undercut or exceeded. In preliminary tests, it has been shown that a sorbitol-containing gel with a pH of 4 is very easily compatible.
Viskositeten skal, på basis av forholdet mellom cellulose og vann, være justert slik at gelen ikke strømmer for lett på den varme hudoverflate, og på den annen side. lett kan fordeles. En viskositet på fra 30 til 60 Pa.s later til å være fordelaktig. The viscosity must, on the basis of the ratio between cellulose and water, be adjusted so that the gel does not flow too easily on the warm skin surface, and on the other side. can easily be distributed. A viscosity of from 30 to 60 Pa.s appears to be advantageous.
De følgende eksempler gies for å illustrere foreliggende oppfinnelse: The following examples are given to illustrate the present invention:
Eksempel 1Example 1
Fremstilling av en gel som er fri for aktive materialer.Preparation of a gel that is free of active materials.
75 g av en 70 vekt%-ig sorbitolløsning oppløses i 883 ml vann inneholdende 2 g PHB-ester som konserveringsmid-del. Denne løsning oppvarmes til 60° C og blandes langsomt under omrøring med 40 g methylhydroxyethylcellulose. Blan-dingen omrøres i 1 - 2 timer inntil den blir homogen og avkjøles i løpet av samme tidsperiode til omgivelsestempera-tur. På denne måte oppnås en gjennomsiktig gel med et pH på 4 og en viskositet på 50 Pa.s ved 20° C som har følgende sammensetning: 75 g of a 70% by weight sorbitol solution is dissolved in 883 ml of water containing 2 g of PHB ester as preservative. This solution is heated to 60° C and mixed slowly with stirring with 40 g of methylhydroxyethylcellulose. The mixture is stirred for 1 - 2 hours until it becomes homogeneous and cooled during the same time period to ambient temperature. In this way, a transparent gel with a pH of 4 and a viscosity of 50 Pa.s at 20° C is obtained which has the following composition:
Eksempel 2 Example 2
Farmasøytisk preparat inneholdende en K<+>/Ca<++->blanding som aktivt materiale (ifølge DE patent 3 416 777). Pharmaceutical preparation containing a K<+>/Ca<++->mixture as active material (according to DE patent 3 416 777).
Ifølge eksempel 1 fremstilles en vandig løsning med en temperatur på 60° C med 30 mmol kalsiumklorid og 40 mmol kaliumklorid som aktiv materialblanding, såvel som med sorbitol for isotonisk justering og PHB-ester som konserve-ringsmiddel og blandes med methylhydroxyethylcellulose. Det oppnås en gel med en pH-verdi på 4,0 og en viskositet på 40 Pa.s. Gelen hadde følgende sammensetning: According to example 1, an aqueous solution with a temperature of 60° C is prepared with 30 mmol calcium chloride and 40 mmol potassium chloride as active material mixture, as well as with sorbitol for isotonic adjustment and PHB ester as preservative and mixed with methylhydroxyethyl cellulose. A gel with a pH value of 4.0 and a viscosity of 40 Pa.s is obtained. The gel had the following composition:
Eksempel 3 Example 3
Farmasøytisk preparat inneholdende en K<+>/Ca<++->blanding som aktivt materiale (ifølge DE patent 3 416 777) . Pharmaceutical preparation containing a K<+>/Ca<++->mixture as active material (according to DE patent 3 416 777).
Ifølge Eksempel 1 fremstilles en vandig løsning ved en temperatur på 60° C med 30 mmol kalsiumklorid og 40 mmol kaliumklorid som aktiv materialblanding, såvel som med sorbitol for isotonisk justering og PHB-ester som konserverings- middel og blandes med methylhydroxyethylcellulose. 0,01 N saltsyre tilsettes så og løsningen omrøres under avkjøling til omgivelsetemperatur for å oppnå en gel med en pH-verdi på 4,0 og en viskositet på 35 Pa.s. Gelen har følgende According to Example 1, an aqueous solution is prepared at a temperature of 60°C with 30 mmol of calcium chloride and 40 mmol of potassium chloride as active material mixture, as well as with sorbitol for isotonic adjustment and PHB ester as preservative and mixed with methylhydroxyethylcellulose. 0.01 N hydrochloric acid is then added and the solution is stirred while cooling to ambient temperature to obtain a gel with a pH value of 4.0 and a viscosity of 35 Pa.s. The gel has the following
sammensetning:composition:
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863614095 DE3614095A1 (en) | 1986-04-25 | 1986-04-25 | OXYALKYLCELLULOSE CONTAINING GEL PREPARATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO871720D0 NO871720D0 (en) | 1987-04-24 |
| NO871720L true NO871720L (en) | 1987-10-26 |
Family
ID=6299560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO871720A NO871720L (en) | 1986-04-25 | 1987-04-24 | OXYALKYL CELLULOSE-CONTAINING GEL MATERIAL. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0247362A3 (en) |
| JP (1) | JPS62254763A (en) |
| CN (1) | CN87103139A (en) |
| AU (1) | AU7196487A (en) |
| DD (1) | DD262530A5 (en) |
| DE (1) | DE3614095A1 (en) |
| DK (1) | DK209087A (en) |
| FI (1) | FI871811A (en) |
| HU (1) | HUT43783A (en) |
| IL (1) | IL82325A0 (en) |
| NO (1) | NO871720L (en) |
| PT (1) | PT84738B (en) |
| YU (1) | YU75187A (en) |
| ZA (1) | ZA872934B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5658592A (en) * | 1994-05-13 | 1997-08-19 | Kuraray Co., Ltd. | Medical crosslinked polymer gel of carboxylic polysaccharide and diaminoalkane |
| CA2906682C (en) | 2013-03-15 | 2024-05-14 | Synedgen Inc. | Compositions comprising poly(acetyl,arginyl) glucosamine (paag) and use thereof for wound healing |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE943793C (en) * | 1955-03-16 | 1956-06-01 | Kade Pharmazeutische Fabrik Dr | Process for the preparation of an agent for treating burn wounds |
| AU7776275A (en) * | 1974-04-11 | 1976-08-05 | Warner Lambert Co | Production of base for topical steroids |
| US4226849A (en) * | 1979-06-14 | 1980-10-07 | Forest Laboratories Inc. | Sustained release therapeutic compositions |
| DE3376957D1 (en) * | 1982-06-24 | 1988-07-14 | Robert Alan Smith | Pharmaceutical gel composition |
| DE3243546A1 (en) * | 1982-11-25 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | ANTIMYCOTIC AGENTS IN GEL FOR TREATING FUNGAL INFECTIONS OF THE ORAL CAVES |
| DE3435113A1 (en) * | 1984-05-07 | 1986-04-03 | Gödecke AG, 7800 Freiburg | PHARMACEUTICAL TOPICAL PREPARATIONS FOR PROMOTING WOUND GRANULATION AND EPITHELISATION |
| BE902226R (en) * | 1985-04-18 | 1985-08-16 | Kowa Co | Analgesic and antiinflammatory ointments - contg. indomethacine and neutralised with ammonia |
-
1986
- 1986-04-25 DE DE19863614095 patent/DE3614095A1/en not_active Withdrawn
-
1987
- 1987-04-22 JP JP62097656A patent/JPS62254763A/en active Pending
- 1987-04-22 PT PT84738A patent/PT84738B/en unknown
- 1987-04-23 DD DD87302067A patent/DD262530A5/en unknown
- 1987-04-24 HU HU871804A patent/HUT43783A/en unknown
- 1987-04-24 DK DK209087A patent/DK209087A/en not_active Application Discontinuation
- 1987-04-24 NO NO871720A patent/NO871720L/en unknown
- 1987-04-24 YU YU00751/87A patent/YU75187A/en unknown
- 1987-04-24 AU AU71964/87A patent/AU7196487A/en not_active Abandoned
- 1987-04-24 EP EP87105999A patent/EP0247362A3/en not_active Withdrawn
- 1987-04-24 ZA ZA872934A patent/ZA872934B/en unknown
- 1987-04-24 IL IL82325A patent/IL82325A0/en unknown
- 1987-04-24 FI FI871811A patent/FI871811A/en not_active Application Discontinuation
- 1987-04-25 CN CN198787103139A patent/CN87103139A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PT84738B (en) | 1989-06-08 |
| EP0247362A2 (en) | 1987-12-02 |
| HUT43783A (en) | 1987-12-28 |
| JPS62254763A (en) | 1987-11-06 |
| YU75187A (en) | 1988-12-31 |
| DD262530A5 (en) | 1988-11-30 |
| FI871811A0 (en) | 1987-04-24 |
| DK209087A (en) | 1987-10-26 |
| AU7196487A (en) | 1987-10-29 |
| DE3614095A1 (en) | 1987-10-29 |
| IL82325A0 (en) | 1987-10-30 |
| FI871811A (en) | 1987-10-26 |
| CN87103139A (en) | 1987-11-18 |
| PT84738A (en) | 1987-05-01 |
| DK209087D0 (en) | 1987-04-24 |
| ZA872934B (en) | 1987-10-19 |
| EP0247362A3 (en) | 1988-10-26 |
| NO871720D0 (en) | 1987-04-24 |
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