NO860366L - Fremgangsm¨te for fremstilling av derivater av oktahydro-1 h-indol-2-karboksylsyrer med antihypertensiv aktivitet. - Google Patents

Fremgangsm¨te for fremstilling av derivater av oktahydro-1 h-indol-2-karboksylsyrer med antihypertensiv aktivitet.

Info

Publication number
NO860366L
NO860366L NO860366A NO860366A NO860366L NO 860366 L NO860366 L NO 860366L NO 860366 A NO860366 A NO 860366A NO 860366 A NO860366 A NO 860366A NO 860366 L NO860366 L NO 860366L
Authority
NO
Norway
Prior art keywords
octahydro
indol
procedure
carboxylic acids
antihypertensive activity
Prior art date
Application number
NO860366A
Other languages
English (en)
Other versions
NO156898C (no
NO156898B (no
Inventor
Milton L Hoefle
George Bobowski
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/233,940 external-priority patent/US4350704A/en
Priority claimed from NO811121A external-priority patent/NO156609C/no
Publication of NO860366L publication Critical patent/NO860366L/no
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO156898B publication Critical patent/NO156898B/no
Publication of NO156898C publication Critical patent/NO156898C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
NO86860366A 1980-04-02 1986-02-03 Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte acylderivater av oktahydro-1h-indol-2-karboksylsyre. NO156898C (no)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13710680A 1980-04-02 1980-04-02
US19430780A 1980-10-06 1980-10-06
US06/233,940 US4350704A (en) 1980-10-06 1981-02-17 Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
NO811121A NO156609C (no) 1980-04-02 1981-04-01 Analogifremgangsmaate for fremstilling av derivater av oktahydro-1h-indol-2-karboksylsyrer med antihypertensiv aktivitet.

Publications (3)

Publication Number Publication Date
NO860366L true NO860366L (no) 1981-10-05
NO156898B NO156898B (no) 1987-09-07
NO156898C NO156898C (no) 1987-12-16

Family

ID=40103606

Family Applications (1)

Application Number Title Priority Date Filing Date
NO86860366A NO156898C (no) 1980-04-02 1986-02-03 Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte acylderivater av oktahydro-1h-indol-2-karboksylsyre.

Country Status (1)

Country Link
NO (1) NO156898C (no)

Also Published As

Publication number Publication date
NO156898C (no) 1987-12-16
NO156898B (no) 1987-09-07

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