NO860204L - Behandling av kvinners haartap. - Google Patents
Behandling av kvinners haartap.Info
- Publication number
- NO860204L NO860204L NO860204A NO860204A NO860204L NO 860204 L NO860204 L NO 860204L NO 860204 A NO860204 A NO 860204A NO 860204 A NO860204 A NO 860204A NO 860204 L NO860204 L NO 860204L
- Authority
- NO
- Norway
- Prior art keywords
- estrogen
- cyproterone acetate
- treatment
- series
- formulation according
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims description 41
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims description 40
- 229960000978 cyproterone acetate Drugs 0.000 claims description 39
- 201000004384 Alopecia Diseases 0.000 claims description 33
- 229940011871 estrogen Drugs 0.000 claims description 32
- 239000000262 estrogen Substances 0.000 claims description 32
- 230000003676 hair loss Effects 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 26
- 239000002552 dosage form Substances 0.000 claims description 24
- 238000009472 formulation Methods 0.000 claims description 24
- 208000024963 hair loss Diseases 0.000 claims description 24
- 238000002360 preparation method Methods 0.000 claims description 19
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 18
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical group OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 18
- 229960002568 ethinylestradiol Drugs 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 15
- 210000004761 scalp Anatomy 0.000 claims description 11
- 230000003779 hair growth Effects 0.000 claims description 10
- 230000000699 topical effect Effects 0.000 claims description 10
- 230000027758 ovulation cycle Effects 0.000 claims description 6
- 239000002207 metabolite Substances 0.000 claims description 4
- 239000000725 suspension Substances 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000004606 Fillers/Extenders Substances 0.000 claims 1
- 230000003645 female-pattern hair loss Effects 0.000 claims 1
- 229940102223 injectable solution Drugs 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000003340 retarding agent Substances 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 210000004209 hair Anatomy 0.000 description 56
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 19
- 230000003803 hair density Effects 0.000 description 14
- 239000003826 tablet Substances 0.000 description 8
- 230000008859 change Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 230000002280 anti-androgenic effect Effects 0.000 description 6
- 239000000051 antiandrogen Substances 0.000 description 6
- 230000009467 reduction Effects 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- 230000002254 contraceptive effect Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 208000002874 Acne Vulgaris Diseases 0.000 description 4
- 206010000496 acne Diseases 0.000 description 4
- 201000002996 androgenic alopecia Diseases 0.000 description 4
- 239000003433 contraceptive agent Substances 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- 230000004044 response Effects 0.000 description 4
- 210000003625 skull Anatomy 0.000 description 4
- 230000009885 systemic effect Effects 0.000 description 4
- 229940124549 vasodilator Drugs 0.000 description 4
- 239000003071 vasodilator agent Substances 0.000 description 4
- 206010047998 Withdrawal bleed Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000003098 androgen Substances 0.000 description 3
- -1 cyclic monophosphate Chemical class 0.000 description 3
- 239000001177 diphosphate Substances 0.000 description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 3
- 235000011180 diphosphates Nutrition 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000011272 standard treatment Methods 0.000 description 3
- 239000001226 triphosphate Substances 0.000 description 3
- 235000011178 triphosphate Nutrition 0.000 description 3
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 206010020112 Hirsutism Diseases 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 2
- 206010047486 Virilism Diseases 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000481 breast Anatomy 0.000 description 2
- 238000011284 combination treatment Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 230000035935 pregnancy Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 208000008811 Agoraphobia Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 101100392078 Caenorhabditis elegans cat-4 gene Proteins 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UQABYHGXWYXDTK-UUOKFMHZSA-N GppNP Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O UQABYHGXWYXDTK-UUOKFMHZSA-N 0.000 description 1
- 101600111816 Homo sapiens Sex hormone-binding globulin (isoform 1) Proteins 0.000 description 1
- 206010066364 Hypersexuality Diseases 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 102300044179 Sex hormone-binding globulin isoform 1 Human genes 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000340 anti-metabolite Effects 0.000 description 1
- 229940100197 antimetabolite Drugs 0.000 description 1
- 239000002256 antimetabolite Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 231100000640 hair analysis Toxicity 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000012731 long-acting form Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000004712 monophosphates Chemical class 0.000 description 1
- 238000012261 overproduction Methods 0.000 description 1
- 238000009595 pap smear Methods 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 208000006155 precocious puberty Diseases 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 229940035722 triiodothyronine Drugs 0.000 description 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
- 229940045145 uridine Drugs 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848413069A GB8413069D0 (en) | 1984-05-22 | 1984-05-22 | Treatment of hair loss |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO860204L true NO860204L (no) | 1986-01-21 |
Family
ID=10561337
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO860204A NO860204L (no) | 1984-05-22 | 1986-01-21 | Behandling av kvinners haartap. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0163489A1 (fr) |
| JP (1) | JPS61502190A (fr) |
| AU (1) | AU4407485A (fr) |
| DK (1) | DK32486A (fr) |
| GB (1) | GB8413069D0 (fr) |
| GR (1) | GR851239B (fr) |
| NO (1) | NO860204L (fr) |
| PT (1) | PT80510B (fr) |
| WO (1) | WO1985005272A1 (fr) |
| ZA (1) | ZA853844B (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571817A (en) * | 1984-02-27 | 1996-11-05 | Merck & Co., Inc. | Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones] |
| DE3738620A1 (de) * | 1987-11-13 | 1989-05-24 | Luderschmidt Christoph | Verwendung von ethisterone zur topischen behandlung von akne oder androgenetischer alopezie |
| WO2000018362A1 (fr) * | 1998-09-28 | 2000-04-06 | Petersen, Sharleen, Caron | Stimulant de la pousse de cheveux |
| US7871599B2 (en) | 2002-07-05 | 2011-01-18 | Unilever Home & Personal Care Usa Division Of Conopco, Inc. | Hair treatment compositions containing xanthine and alpha hydroxy acid |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3942641A (en) * | 1972-05-05 | 1976-03-09 | Syntex Corporation | Dispensing packages containing novel cyclic progestogen-interrupted estrogen oral contraceptive regimens |
| DE2757024C3 (de) * | 1977-12-21 | 1981-01-22 | Juergen Prof. Dr.Med. 2000 Hamburg Tamm | Kosmetisches Haar- und Hautpflegemittel |
| DE3003036A1 (de) * | 1980-01-29 | 1981-07-30 | Irmgard von Dr.med. 5300 Bonn Kistowski | Mittel zur verhinderung und beseitigung von glatzen |
-
1984
- 1984-05-22 GB GB848413069A patent/GB8413069D0/en active Pending
-
1985
- 1985-05-21 GR GR851239A patent/GR851239B/el unknown
- 1985-05-21 ZA ZA853844A patent/ZA853844B/xx unknown
- 1985-05-22 JP JP60502447A patent/JPS61502190A/ja active Pending
- 1985-05-22 EP EP85303623A patent/EP0163489A1/fr not_active Withdrawn
- 1985-05-22 AU AU44074/85A patent/AU4407485A/en not_active Abandoned
- 1985-05-22 WO PCT/GB1985/000218 patent/WO1985005272A1/fr unknown
- 1985-05-22 PT PT80510A patent/PT80510B/pt unknown
-
1986
- 1986-01-21 NO NO860204A patent/NO860204L/no unknown
- 1986-01-22 DK DK32486A patent/DK32486A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU4407485A (en) | 1985-12-13 |
| ZA853844B (en) | 1986-07-30 |
| DK32486D0 (da) | 1986-01-22 |
| PT80510A (en) | 1985-06-01 |
| JPS61502190A (ja) | 1986-10-02 |
| GR851239B (fr) | 1985-11-25 |
| EP0163489A1 (fr) | 1985-12-04 |
| GB8413069D0 (en) | 1984-06-27 |
| DK32486A (da) | 1986-01-22 |
| WO1985005272A1 (fr) | 1985-12-05 |
| PT80510B (en) | 1986-12-16 |
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