NO823124L - Fremgangsmaate for fremstilling av en vaksine mot vibrio anguillarum. - Google Patents
Fremgangsmaate for fremstilling av en vaksine mot vibrio anguillarum.Info
- Publication number
- NO823124L NO823124L NO823124A NO823124A NO823124L NO 823124 L NO823124 L NO 823124L NO 823124 A NO823124 A NO 823124A NO 823124 A NO823124 A NO 823124A NO 823124 L NO823124 L NO 823124L
- Authority
- NO
- Norway
- Prior art keywords
- cells
- vibrio anguillarum
- iron
- plasmid
- protein
- Prior art date
Links
- 241000544286 Vibrio anguillarum Species 0.000 title claims description 37
- 229960005486 vaccine Drugs 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 14
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 99
- 229910052742 iron Inorganic materials 0.000 claims description 49
- 102000004169 proteins and genes Human genes 0.000 claims description 16
- 108090000623 proteins and genes Proteins 0.000 claims description 16
- 230000001717 pathogenic effect Effects 0.000 claims description 11
- 241000607598 Vibrio Species 0.000 claims description 10
- 101710116435 Outer membrane protein Proteins 0.000 claims description 9
- 239000012528 membrane Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 239000001963 growth medium Substances 0.000 claims description 2
- 230000003313 weakening effect Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 description 35
- 239000013612 plasmid Substances 0.000 description 34
- 230000001018 virulence Effects 0.000 description 19
- 235000018102 proteins Nutrition 0.000 description 14
- 239000002609 medium Substances 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 8
- 235000019688 fish Nutrition 0.000 description 7
- 244000052769 pathogen Species 0.000 description 7
- 241000707150 Vibrio anguillarum 775 Species 0.000 description 6
- 206010047400 Vibrio infections Diseases 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 102000004338 Transferrin Human genes 0.000 description 5
- 108090000901 Transferrin Proteins 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229910021578 Iron(III) chloride Inorganic materials 0.000 description 4
- 102000018697 Membrane Proteins Human genes 0.000 description 4
- 108010052285 Membrane Proteins Proteins 0.000 description 4
- 241000277338 Oncorhynchus kisutch Species 0.000 description 4
- 230000035508 accumulation Effects 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 230000001580 bacterial effect Effects 0.000 description 4
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 4
- 230000002285 radioactive effect Effects 0.000 description 4
- 239000012581 transferrin Substances 0.000 description 4
- 241000972773 Aulopiformes Species 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 3
- 241000277277 Oncorhynchus nerka Species 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 235000019515 salmon Nutrition 0.000 description 3
- 241000251468 Actinopterygii Species 0.000 description 2
- 229910021577 Iron(II) chloride Inorganic materials 0.000 description 2
- 102000008133 Iron-Binding Proteins Human genes 0.000 description 2
- 108010035210 Iron-Binding Proteins Proteins 0.000 description 2
- 108010063045 Lactoferrin Proteins 0.000 description 2
- 102100032241 Lactotransferrin Human genes 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- NMCUIPGRVMDVDB-UHFFFAOYSA-L iron dichloride Chemical compound Cl[Fe]Cl NMCUIPGRVMDVDB-UHFFFAOYSA-L 0.000 description 2
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 2
- 229940078795 lactoferrin Drugs 0.000 description 2
- 235000021242 lactoferrin Nutrition 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000000241 respiratory effect Effects 0.000 description 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- 229920000936 Agarose Polymers 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102100034349 Integrase Human genes 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- 101710164702 Major outer membrane protein Proteins 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241000277331 Salmonidae Species 0.000 description 1
- 101100294399 Schizosaccharomyces pombe (strain 972 / ATCC 24843) not1 gene Proteins 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 239000000589 Siderophore Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000008260 defense mechanism Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 235000014304 histidine Nutrition 0.000 description 1
- 230000009215 host defense mechanism Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007154 intracellular accumulation Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 238000009372 pisciculture Methods 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000013223 septicemia Diseases 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 235000010344 sodium nitrate Nutrition 0.000 description 1
- 239000004317 sodium nitrate Substances 0.000 description 1
- DZCAZXAJPZCSCU-UHFFFAOYSA-K sodium nitrilotriacetate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O DZCAZXAJPZCSCU-UHFFFAOYSA-K 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/107—Vibrio
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22576481A | 1981-01-16 | 1981-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO823124L true NO823124L (no) | 1982-09-15 |
Family
ID=22846135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO823124A NO823124L (no) | 1981-01-16 | 1982-09-15 | Fremgangsmaate for fremstilling av en vaksine mot vibrio anguillarum. |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS58500026A (da) |
| DK (1) | DK414082A (da) |
| ES (1) | ES8304801A1 (da) |
| FR (1) | FR2509177A1 (da) |
| IT (1) | IT1154265B (da) |
| NO (1) | NO823124L (da) |
| SE (1) | SE8205247D0 (da) |
| WO (1) | WO1982002491A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK189788D0 (da) * | 1988-04-07 | 1988-04-07 | Wolf Watz Hans | Vaccine |
| CA2097830C (en) * | 1990-12-04 | 2000-02-01 | Stephen G. Newman | Spray-dried antigenic products and method of preparation |
| GB9112310D0 (en) * | 1991-06-07 | 1991-07-24 | United Kingdom Government | Fish vaccine |
| EP0640348A1 (en) * | 1993-07-26 | 1995-03-01 | Akzo Nobel N.V. | Oil-based and water-based adjuvant mixture |
| CN1276076C (zh) | 2004-12-14 | 2006-09-20 | 华东理工大学 | 一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862313A (en) * | 1974-01-17 | 1975-01-21 | Us Interior | Vibrio vaccine and immunization |
-
1982
- 1982-01-14 FR FR8200510A patent/FR2509177A1/fr active Pending
- 1982-01-15 WO PCT/US1982/000039 patent/WO1982002491A1/en active Application Filing
- 1982-01-15 ES ES508767A patent/ES8304801A1/es not_active Expired
- 1982-01-15 JP JP57500739A patent/JPS58500026A/ja active Pending
- 1982-01-15 IT IT47575/82A patent/IT1154265B/it active
- 1982-09-14 SE SE8205247A patent/SE8205247D0/xx not_active Application Discontinuation
- 1982-09-15 NO NO823124A patent/NO823124L/no unknown
- 1982-09-16 DK DK414082A patent/DK414082A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2509177A1 (fr) | 1983-01-14 |
| ES508767A0 (es) | 1983-03-16 |
| IT1154265B (it) | 1987-01-21 |
| ES8304801A1 (es) | 1983-03-16 |
| DK414082A (da) | 1982-09-16 |
| IT8247575A0 (it) | 1982-01-15 |
| SE8205247L (sv) | 1982-09-14 |
| WO1982002491A1 (en) | 1982-08-05 |
| SE8205247D0 (sv) | 1982-09-14 |
| JPS58500026A (ja) | 1983-01-06 |
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