NO792586L - PACKAGE. - Google Patents
PACKAGE.Info
- Publication number
- NO792586L NO792586L NO792586A NO792586A NO792586L NO 792586 L NO792586 L NO 792586L NO 792586 A NO792586 A NO 792586A NO 792586 A NO792586 A NO 792586A NO 792586 L NO792586 L NO 792586L
- Authority
- NO
- Norway
- Prior art keywords
- inner container
- protective sleeve
- package
- outer protective
- plastic
- Prior art date
Links
- 230000001681 protective effect Effects 0.000 claims description 20
- 229920003023 plastic Polymers 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000004033 plastic Substances 0.000 claims description 8
- 239000007787 solid Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000007911 parenteral administration Methods 0.000 claims description 2
- 239000002274 desiccant Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 238000012856 packing Methods 0.000 description 5
- 230000001954 sterilising effect Effects 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 4
- 239000004800 polyvinyl chloride Substances 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 3
- 239000004927 clay Substances 0.000 description 3
- -1 polypropylene Polymers 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 229920000915 polyvinyl chloride Polymers 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002650 laminated plastic Substances 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 229920004439 Aclar® Polymers 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 239000005023 polychlorotrifluoroethylene (PCTFE) polymer Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Food Science & Technology (AREA)
- Packages (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Description
Pakning.Packing.
Den foreliggende oppfinnelse vedrører enThe present invention relates to a
pakning for oppløsninger for parenteral administrering og bestående av en indre lukket beholder av plast, i hvilken indre beholder nevnte oppløsning er innesluttet, og et ytre, for mikroorganismer ugjennomtrengelig beskyttelseshylster av plast som omslutter nevnte indre beholder. package for solutions for parenteral administration and consisting of an inner closed container made of plastic, in which inner container said solution is contained, and an outer, for micro-organisms impermeable protective sleeve made of plastic which encloses said inner container.
Pakninger av dette slag er kjent fra ålmentSeals of this type are known from the commons
bruk.use.
Den indre beholder er når det gjelderThe inner container is where it belongs
materialet begrenset til av myndighetene godkjent materiale, fortrinnsvis polyvinylklorid (PVC) og polypropen. Det ytre beskyttelseshylster har vært fremstilt av diverse plastmaterialer og tjener foruten som beskyttelseshylster, til å minske fuktgjennomgangen fra den innesluttede oppløsning. the material limited to materials approved by the authorities, preferably polyvinyl chloride (PVC) and polypropylene. The outer protective sleeve has been made of various plastic materials and also serves as a protective sleeve to reduce the passage of moisture from the enclosed solution.
Ved varmesterilisering av en slik pakning i autoklav med vanndamp, skjer en vannopptagning i materialet til den indre beholder slik at dette blir opakt. Denne opasitet forblir etter steriliseringens slutt og er observert på pakninger som har vært lagret i flere år. Ettersom opasiteten forhindrer eller vanskeliggjør inspeksjon av den innesluttede oppløsning, innebærer den en høyst vesentlig ulempe. When heat sterilizing such a package in an autoclave with steam, water is absorbed into the material of the inner container so that it becomes opaque. This opacity remains after the end of sterilization and has been observed on packages that have been stored for several years. As the opacity prevents or makes inspection of the contained solution difficult, it entails a very significant disadvantage.
Ifølge foreliggende oppfinnelse har en nåAccording to the present invention, one now has
funnet at nevnte ulempe kan unngås med en pakning av oven-nevnte slag, hvilken erkarakterisert vedat såvel den indre beholder som det ytre beskyttelseshylster består av transparente plastmaterialer og at det på minst ett sted i mellomrommet mellom den indre beholder og det' ytre beskyttelseshylster, er anbrakt et fysiologisk akseptabelt middel som found that said disadvantage can be avoided with a package of the above-mentioned type, which is characterized by the fact that both the inner container and the outer protective sleeve consist of transparent plastic materials and that in at least one place in the space between the inner container and the outer protective sleeve, placed a physiologically acceptable agent which
foreligger i fast form ved de forskjellige temperatur- og andre betingelser som pakningen utsettes for og som ved kontakt med vannholdig luft kan oppta vanndamp fra luften, exists in solid form at the various temperature and other conditions to which the packing is exposed and which, on contact with water-containing air, can absorb water vapor from the air,
i det minste innen et temperaturintérvall fra 10 til 30°C. at least within a temperature interval from 10 to 30°C.
Oppfinnelsen skal beskrives nærmere i det følgende med henvisning til den vedlagte tegning som viser et perspektivriss av en utførelsesform av en jSakning ifølge oppfinnelsen. The invention shall be described in more detail below with reference to the attached drawing which shows a perspective view of an embodiment of a jSaking according to the invention.
Tegningen viser en indre beholder 1 som er forsynt med et lukke 2, et ytre beskyttelseshylster 3 og et mellom den indre beholder 1 og det ytre -beskyttelseshylster 3 plassert forråd 4 av tørkemiddel. The drawing shows an inner container 1 which is provided with a closure 2, an outer protective sleeve 3 and a supply 4 of desiccant placed between the inner container 1 and the outer protective sleeve 3.
Forrådet 4 utgjøres fortrinnsvis av en beholder med vegger av et for vanndamp gjennomtrengbart materiale, f.eks.papir eller tekstilmateriale,og i hvilket et tørkemiddel i mer eller mindre finfordelt form er inne-lukket. The supply 4 preferably consists of a container with walls of a material permeable to water vapour, e.g. paper or textile material, and in which a desiccant in more or less finely divided form is enclosed.
Som tørkemiddel kan anvendes hvert i og forAs a drying agent can be used in and for
seg som tørkemiddel kjent substans forutsatt at den besitter tilstrekkelig fysiologisk uskadelighet for å kunne bli godkjent..av myndighetene i denne anvendelsesforbindelse, samt foreligger i fast form ved de forskjellige temperatur- og andre betingelser som pakningen utsettes for, omfattende at den fortsatt foreligger i fast form ved steriliserings-temperaturen og ikke smelter eller oppsmuldres ved denne temperatur, samt at den ikke går i oppløsning ved kontakt med store mengder vanndamp. (Som tørkemiddel kan således f.eks. endog velges slike som opptar vanndamp fra luften i et større temperaturintérvallj(f.eks. 0-50°C) enn det ovenfor angitte og ved varierende relative fuktigheter (f.eks. 90-100%, 80 - 100% eller 70-100% eller eventuelt et større intervall).). Eksempel på hensiktsmessige substanser■for dette er tørket a substance known as a desiccant, provided that it possesses sufficient physiological innocuousness to be approved by the authorities in this application, and is in solid form at the various temperature and other conditions to which the packaging is exposed, including that it is still in solid form form at the sterilization temperature and does not melt or crumble at this temperature, and that it does not dissolve in contact with large quantities of water vapour. (As desiccants, for example, you can even choose those that absorb water vapor from the air in a larger temperature range (e.g. 0-50°C) than that stated above and at varying relative humidities (e.g. 90-100% , 80 - 100% or 70-100% or possibly a larger interval).). Examples of suitable substances■for this are dried
ren leire og silikagel. Mengden tørkemiddel beror av middelets vannopptagningsevne, steriliseringstidens lengde, pakningens flate samt materialene i den indre beholder og det ytre beskyttelseshylster. Por pakninger med 500 ml oppløsning er vanligvis en mengde på 5-10 g tørket ren leire fullt tilstrekkelig for oppnåelse av den ettersøkte effekt. Endog mengder under den laveste av disse verdier kan dog gi nevnte pure clay and silica gel. The amount of desiccant depends on the agent's water absorption capacity, the length of the sterilization time, the surface of the package and the materials in the inner container and the outer protective sleeve. Por packs with 500 ml of solution are usually an amount of 5-10 g of dried pure clay fully sufficient to achieve the desired effect. Even quantities below the lowest of these values can, however, give the aforementioned
effekt likeledes som mengder over den største av verdiene. effect as well as quantities above the largest of the values.
Pakningens størrelse kan varieres innen vide grenser og muliggjør anvendelse av pakningen for f.eks. The size of the packing can be varied within wide limits and enables the use of the packing for e.g.
100 - 3000 ml oppløsning. Oppfinnelsen kan således tillempes forekommende små pakninger på 100 - 300 ml og til forekommende større pakninger på f.eks. 500 ml, 1000 ml og 3000 ml. Avhengig av pakningens størrelse bør tørkemiddelét vanligvis kunne oppta 0,3 - 5 g vann ved de betingelser som råder i mellomrommet mellom den indre beholder og det ytre beskyttelseshylster. 100 - 3000 ml solution. The invention can thus be applied to existing small packages of 100 - 300 ml and to existing larger packages of e.g. 500 ml, 1000 ml and 3000 ml. Depending on the size of the package, the desiccant should usually be able to absorb 0.3 - 5 g of water under the conditions prevailing in the space between the inner container and the outer protective sleeve.
Luftevolumet mellom den indre beholder og det ytre beskyttelseshylster velges'i avhengighet av pakningens størrelse og er vanligvis innen grensene 30 til 500 ml. The air volume between the inner container and the outer protective sleeve is chosen depending on the size of the package and is usually within the limits of 30 to 500 ml.
Tørkemiddelforrådets plassering i forhold tilThe location of the desiccant storage in relation to
den indre beholder kan være etter ønske. I tegningen er forrådet plassert utenfor den indre beholders ene kortende for tydelighets skyld, men av praktiske grunner ved fremstilling av pakningen, kan det være mer fordelaktig å plassere dette over eller under den indre beholder. the inner container can be as desired. In the drawing, the storage is placed outside the one short end of the inner container for the sake of clarity, but for practical reasons when manufacturing the packing, it may be more advantageous to place this above or below the inner container.
I stedet for et eneste stort forråd, kan detInstead of a single large warehouse, it can
i og for seg anvendes flere mindre forråd. Det er dog ønske-lig at spredningen til tørkemiddelét er liten for at det skal oppnås størst mulig siktbarhet i pakningen. in and of itself, several smaller stores are used. However, it is desirable that the spread of the desiccant is small in order to achieve the greatest possible visibility in the packaging.
Forrådet av tørkemiddel tørrdestileres fortrinnsvis før innføring i pakningen. Pakningens fremstilling skjer på i og for seg kjent vis idet tørkemiddelét innføres i mellomrommet mellom den indre beholder og beskyttelseshylsteret i forbindelse med sistnevntes anbringelse og før dettes lukking. The supply of desiccant is preferably dry-distilled before introduction into the package. The packaging is made in a manner known per se, as the desiccant is introduced into the space between the inner container and the protective sleeve in connection with the latter's placement and before its closure.
En fordel er at hele pakningsprosedyren og den derpå følgende sterilisering kan utføres i en rekkefølge. An advantage is that the entire packaging procedure and the subsequent sterilization can be carried out in a sequence.
Som plastmateriale i den indre beholder anvendes med fordel transparent PVC. Det ytre beskyttelseshylster kan med fordel bestå av et transparent plastlaminat, f.eks. av polypropen og polyester,(eller eventuelt polyamid eller fluprohalokarbonplaster (f.eks. Aclar ( R))). Transparent PVC is preferably used as plastic material in the inner container. The outer protective sleeve can advantageously consist of a transparent plastic laminate, e.g. of polypropylene and polyester, (or possibly polyamide or fluprohalocarbon plaster (e.g. Aclar ( R))).
En vesentlig fordel er at oppløsningen i den indre beholder kan besiktiges ikke bare etter at det ytre beskyttelseshylster er fjernet, men også når dette sitter igjen A significant advantage is that the solution in the inner container can be inspected not only after the outer protective sleeve has been removed, but also when it remains
rundt den indre beholder.around the inner container.
EksempelExample
Transparente plastposer av PVC (med tykkelse 0,35 mm for plastmaterialet) godkjent for parenterale infusjonsoppløsninger og som rommer 500 ml ble fylt med fysiologisk koksaltoppløsning (dvs. inneholdende 0,9 g NaCl pr. 100 ml vannoppløsning) og lukkes. Den fylte PVC-pose ble pakket i et indre beskyttelseshylster av transparent plastlaminat med en total tykkelse på 0,112 mm og bestående av et ytre sjikt av polypropen og et indre sjikt av polyester (tykkelse 0,012 mm) og samtidig ble det i mellomrommet mellom den indre pose og beskyttelseshylsteret anbrakt en liten papirpose fylt med 5 g Sen leire som på for-hånd var tørrdestillert ved 140°C i 8 timer. Deretter ble det ytre beskyttelseshylster helt lukket rundt den indre beholder ved ombretting og varmeforsegling. Deretter ble pakningene varmesterilisert i autoklav ved vanndamp ved 121°C i 10 minutter. Oppløsningen i de ferdige pakninger kunne , besiktiges med det ytre beskyttelseshylster rundt den indre plastposen. Transparent plastic bags made of PVC (with a thickness of 0.35 mm for the plastic material) approved for parenteral infusion solutions and holding 500 ml were filled with physiological saline solution (ie containing 0.9 g of NaCl per 100 ml of water solution) and closed. The filled PVC bag was packed in an inner protective sheath of transparent plastic laminate with a total thickness of 0.112 mm and consisting of an outer layer of polypropylene and an inner layer of polyester (thickness 0.012 mm) and at the same time in the space between the inner bag and the protective sleeve placed a small paper bag filled with 5 g of Sen clay which had previously been dry-distilled at 140°C for 8 hours. The outer protective sleeve was then completely closed around the inner container by crimping and heat sealing. The packs were then heat sterilized in an autoclave using steam at 121°C for 10 minutes. The solution in the finished packs could be inspected with the outer protective sleeve around the inner plastic bag.
Claims (1)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7808995A SE413304B (en) | 1978-08-25 | 1978-08-25 | pACKING |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO792586L true NO792586L (en) | 1980-02-26 |
Family
ID=20335659
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO792586A NO792586L (en) | 1978-08-25 | 1979-08-07 | PACKAGE. |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5564072A (en) |
| DE (1) | DE2933071A1 (en) |
| DK (1) | DK353879A (en) |
| FI (1) | FI792602A (en) |
| FR (1) | FR2433940A1 (en) |
| GB (1) | GB2029363A (en) |
| NO (1) | NO792586L (en) |
| SE (1) | SE413304B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3039093A1 (en) * | 1980-10-16 | 1982-05-13 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | METHOD FOR PACKAGING PARENTERALIA IN STEAM-STABILIZABLE, CLEAR-SIGHTED CONTAINERS MADE OF SOFT PLASTICS |
| JPS57206447A (en) * | 1981-06-12 | 1982-12-17 | Terumo Corp | Plastic container receiving liquid drug pasturized with high pressure steam and production thereof |
| US4777780A (en) * | 1987-04-21 | 1988-10-18 | United States Surgical Corporation | Method for forming a sealed sterile package |
| FR2618762B1 (en) * | 1987-07-30 | 1989-12-29 | Roussel Uclaf | DEVICE FOR THE EXTENDED STORAGE OF NUTRIENT PRODUCTS |
| GR1001148B (en) * | 1988-01-20 | 1993-05-24 | Roussel Uclaf | Disposition allowing an extended storing of nutrition products |
| US6406674B1 (en) | 1993-06-30 | 2002-06-18 | Kimberly-Clark Worldwide, Inc. | Single step sterilization wrap system |
| WO1996013449A1 (en) * | 1994-10-31 | 1996-05-09 | Getinge Ab | Waste disposal container |
| GB9505425D0 (en) * | 1995-03-17 | 1995-05-03 | Unilever Plc | Assay devices |
| DE19655056C2 (en) * | 1996-01-10 | 2001-03-01 | Nutrichem Diaet & Pharma Gmbh | Disposable bag for storing e.g. blood, blood plasma, etc. |
| US7922983B2 (en) | 2005-07-28 | 2011-04-12 | Kimberly-Clark Worldwide, Inc. | Sterilization wrap with additional strength sheet |
| WO2009024946A1 (en) * | 2007-08-21 | 2009-02-26 | Ranbaxy Laboratories Limited | A packaging kit comprising a light, moisture and/or oxygen sensitive drug |
| AT508683B1 (en) * | 2009-09-03 | 2013-09-15 | Croma Pharma Gmbh | METHOD FOR PRODUCING A CONTAINER INSERTED IN A PROTECTIVE CASING |
-
1978
- 1978-08-25 SE SE7808995A patent/SE413304B/en unknown
-
1979
- 1979-08-07 NO NO792586A patent/NO792586L/en unknown
- 1979-08-16 DE DE19792933071 patent/DE2933071A1/en not_active Withdrawn
- 1979-08-21 FI FI792602A patent/FI792602A/en not_active Application Discontinuation
- 1979-08-22 FR FR7921149A patent/FR2433940A1/en not_active Withdrawn
- 1979-08-24 JP JP10732179A patent/JPS5564072A/en active Pending
- 1979-08-24 DK DK353879A patent/DK353879A/en unknown
- 1979-08-24 GB GB7929530A patent/GB2029363A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5564072A (en) | 1980-05-14 |
| FR2433940A1 (en) | 1980-03-21 |
| DK353879A (en) | 1980-02-26 |
| SE7808995L (en) | 1980-02-26 |
| DE2933071A1 (en) | 1980-03-06 |
| GB2029363A (en) | 1980-03-19 |
| SE413304B (en) | 1980-05-19 |
| FI792602A (en) | 1980-02-26 |
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