NO762002L - - Google Patents
Info
- Publication number
- NO762002L NO762002L NO762002A NO762002A NO762002L NO 762002 L NO762002 L NO 762002L NO 762002 A NO762002 A NO 762002A NO 762002 A NO762002 A NO 762002A NO 762002 L NO762002 L NO 762002L
- Authority
- NO
- Norway
- Prior art keywords
- formula
- compound
- compounds
- benzo
- stands
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 claims description 22
- 238000000034 method Methods 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 125000000217 alkyl group Chemical group 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- FMRWQLAJBBKXDM-UHFFFAOYSA-N 2,2,5,5-tetramethylpyrrolidine Chemical compound CC1(C)CCC(C)(C)N1 FMRWQLAJBBKXDM-UHFFFAOYSA-N 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims description 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- -1 3-amino-2-hydroxy-propoxy compounds Chemical class 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 150000002924 oxiranes Chemical class 0.000 description 2
- 235000011121 sodium hydroxide Nutrition 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- SDGKUVSVPIIUCF-KNVOCYPGSA-N (2r,6s)-2,6-dimethylpiperidine Chemical compound C[C@H]1CCC[C@@H](C)N1 SDGKUVSVPIIUCF-KNVOCYPGSA-N 0.000 description 1
- YYTSGNJTASLUOY-UHFFFAOYSA-N 1-chloropropan-2-ol Chemical class CC(O)CCl YYTSGNJTASLUOY-UHFFFAOYSA-N 0.000 description 1
- CGDANWBJDWOAMN-UHFFFAOYSA-N 4-(3-chloro-2-hydroxypropoxy)benzo[1,2]cyclohepta[3,4-b]thiophen-10-one Chemical compound ClCC(O)COC1=CC2=CC=CC=C2C(=O)C2=C1SC=C2 CGDANWBJDWOAMN-UHFFFAOYSA-N 0.000 description 1
- LLBZPESJRQGYMB-UHFFFAOYSA-N 4-one Natural products O1C(C(=O)CC)CC(C)C11C2(C)CCC(C3(C)C(C(C)(CO)C(OC4C(C(O)C(O)C(COC5C(C(O)C(O)CO5)OC5C(C(OC6C(C(O)C(O)C(CO)O6)O)C(O)C(CO)O5)OC5C(C(O)C(O)C(C)O5)O)O4)O)CC3)CC3)=C3C2(C)CC1 LLBZPESJRQGYMB-UHFFFAOYSA-N 0.000 description 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 125000005605 benzo group Chemical group 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001721 carbon Chemical group 0.000 description 1
- 206010061592 cardiac fibrillation Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002600 fibrillogenic effect Effects 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH792275A CH615928A5 (de) | 1975-06-18 | 1975-06-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO762002L true NO762002L (de) | 1976-12-21 |
Family
ID=4332426
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO762002A NO762002L (de) | 1975-06-18 | 1976-06-10 |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4031225A (de) |
| JP (1) | JPS523053A (de) |
| AT (1) | ATA443576A (de) |
| AU (1) | AU505336B2 (de) |
| BE (1) | BE843039A (de) |
| CA (1) | CA1069509A (de) |
| CH (1) | CH615928A5 (de) |
| DD (1) | DD125077A5 (de) |
| DE (1) | DE2625642A1 (de) |
| DK (1) | DK256676A (de) |
| ES (1) | ES448995A1 (de) |
| FI (1) | FI761643A (de) |
| FR (1) | FR2314715A1 (de) |
| GB (1) | GB1545521A (de) |
| IE (1) | IE43602B1 (de) |
| IL (1) | IL49806A (de) |
| NL (1) | NL7606387A (de) |
| NO (1) | NO762002L (de) |
| NZ (1) | NZ181177A (de) |
| PH (1) | PH11642A (de) |
| PT (1) | PT65235B (de) |
| SE (1) | SE7606460L (de) |
| SU (1) | SU597337A3 (de) |
| YU (1) | YU150576A (de) |
| ZA (1) | ZA763628B (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5512017Y2 (de) * | 1974-12-24 | 1980-03-15 | ||
| WO2006079637A1 (en) | 2005-01-27 | 2006-08-03 | Janssen Pharmaceutica N.V. | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders |
| CN109293627B (zh) * | 2018-11-24 | 2022-08-30 | 临海市华南化工有限公司 | 一种酮替芬中间体母液的回收方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856818A (en) * | 1972-07-03 | 1974-12-24 | Squibb & Sons Inc | Tricyclic phenoxy aminopropanols |
-
1975
- 1975-06-18 CH CH792275A patent/CH615928A5/de not_active IP Right Cessation
-
1976
- 1976-05-31 FR FR7616311A patent/FR2314715A1/fr active Granted
- 1976-06-08 DE DE19762625642 patent/DE2625642A1/de not_active Withdrawn
- 1976-06-09 FI FI761643A patent/FI761643A/fi not_active Application Discontinuation
- 1976-06-09 SE SE7606460A patent/SE7606460L/xx unknown
- 1976-06-09 DK DK256676A patent/DK256676A/da not_active Application Discontinuation
- 1976-06-10 NO NO762002A patent/NO762002L/no unknown
- 1976-06-14 US US05/695,384 patent/US4031225A/en not_active Expired - Lifetime
- 1976-06-14 SU SU762371098A patent/SU597337A3/ru active
- 1976-06-14 NL NL7606387A patent/NL7606387A/xx not_active Application Discontinuation
- 1976-06-15 GB GB24723/76A patent/GB1545521A/en not_active Expired
- 1976-06-16 DD DD193395A patent/DD125077A5/xx unknown
- 1976-06-16 AT AT443576A patent/ATA443576A/de not_active Application Discontinuation
- 1976-06-16 CA CA254,980A patent/CA1069509A/en not_active Expired
- 1976-06-16 NZ NZ181177A patent/NZ181177A/xx unknown
- 1976-06-16 PH PH18576A patent/PH11642A/en unknown
- 1976-06-16 IL IL49806A patent/IL49806A/xx unknown
- 1976-06-16 PT PT65235A patent/PT65235B/pt unknown
- 1976-06-16 BE BE168004A patent/BE843039A/xx unknown
- 1976-06-17 JP JP51070457A patent/JPS523053A/ja active Pending
- 1976-06-17 IE IE1304/76A patent/IE43602B1/en unknown
- 1976-06-18 AU AU15064/76A patent/AU505336B2/en not_active Expired
- 1976-06-18 ES ES448995A patent/ES448995A1/es not_active Expired
- 1976-06-18 YU YU01505/76A patent/YU150576A/xx unknown
- 1976-06-18 ZA ZA00763628A patent/ZA763628B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SU597337A3 (ru) | 1978-03-05 |
| US4031225A (en) | 1977-06-21 |
| PH11642A (en) | 1978-05-08 |
| FI761643A (de) | 1976-12-19 |
| PT65235B (fr) | 1978-03-24 |
| ATA443576A (de) | 1981-04-15 |
| FR2314715A1 (fr) | 1977-01-14 |
| IE43602L (en) | 1976-12-18 |
| ZA763628B (en) | 1978-01-25 |
| IL49806A0 (en) | 1976-08-31 |
| FR2314715B1 (de) | 1978-11-03 |
| DD125077A5 (de) | 1977-03-30 |
| NZ181177A (en) | 1978-06-02 |
| NL7606387A (nl) | 1976-12-21 |
| PT65235A (fr) | 1976-07-01 |
| GB1545521A (en) | 1979-05-10 |
| AU1506476A (en) | 1977-12-22 |
| BE843039A (fr) | 1976-12-16 |
| IL49806A (en) | 1979-10-31 |
| YU150576A (en) | 1982-05-31 |
| CA1069509A (en) | 1980-01-08 |
| SE7606460L (sv) | 1976-12-19 |
| IE43602B1 (en) | 1981-04-08 |
| DK256676A (da) | 1976-12-19 |
| ES448995A1 (es) | 1977-12-01 |
| AU505336B2 (en) | 1979-11-15 |
| JPS523053A (en) | 1977-01-11 |
| DE2625642A1 (de) | 1977-01-13 |
| CH615928A5 (de) | 1980-02-29 |
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