NO347360B1 - Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. - Google Patents
Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. Download PDFInfo
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- NO347360B1 NO347360B1 NO20150450A NO20150450A NO347360B1 NO 347360 B1 NO347360 B1 NO 347360B1 NO 20150450 A NO20150450 A NO 20150450A NO 20150450 A NO20150450 A NO 20150450A NO 347360 B1 NO347360 B1 NO 347360B1
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- Prior art keywords
- maytansinoid
- binding agent
- conjugate
- cell
- cell binding
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50990103P | 2003-10-10 | 2003-10-10 | |
| PCT/US2004/030917 WO2005037992A2 (en) | 2003-10-10 | 2004-10-12 | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
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| Publication Number | Publication Date |
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| NO20150450L NO20150450L (no) | 2006-04-21 |
| NO347360B1 true NO347360B1 (no) | 2023-09-25 |
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| NO20150450A NO347360B1 (no) | 2003-10-10 | 2004-10-12 | Cellebindingsmiddelmaytansinoid-konjugat med formel trastuzumab-SMCC-DM1 eller trastuzumab-SIABDM1, fremgangsmåte for fremstilling av disse og en in vitro fremgangsmåte for å styre maytansinoider til en valgt cellepopulasjon eller for å eliminere celler, samt anvendelse. |
| NO20160447A NO20160447A1 (no) | 2003-10-10 | 2016-03-16 | Fremgangsmåte for målsøking av spesifikke cellepopulasjoner ved å benytte cellebindings-middelmaytansinoidkonjugater bundet via en ikke-kløyvbar linker, nevnte konjugater og fremstilling av nevnte konjugater |
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| NO20160447A NO20160447A1 (no) | 2003-10-10 | 2016-03-16 | Fremgangsmåte for målsøking av spesifikke cellepopulasjoner ved å benytte cellebindings-middelmaytansinoidkonjugater bundet via en ikke-kløyvbar linker, nevnte konjugater og fremstilling av nevnte konjugater |
Country Status (3)
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| CN (1) | CN101087611B (zh) |
| NO (2) | NO347360B1 (zh) |
| ZA (1) | ZA200601182B (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06014065A (es) * | 2004-06-01 | 2007-01-31 | Genentech Inc | Conjugados de droga-anticuerpo y metodos. |
| CN109045307A (zh) * | 2004-06-01 | 2018-12-21 | 健泰科生物技术公司 | 抗体-药物偶联物和方法 |
| BRPI0911442A2 (pt) * | 2008-04-30 | 2019-03-12 | Immunogen, Inc. | conjugados potentes e ligantes hidrofílicos |
| CA2816426A1 (en) * | 2010-11-17 | 2012-06-07 | Genentech, Inc. | Alaninyl maytansinol antibody conjugates |
| CA2831562A1 (en) * | 2011-03-29 | 2012-10-04 | Immunogen, Inc. | Process for manufacturing conjugates of improved homogeneity |
| CN107982545B (zh) * | 2012-05-15 | 2021-04-09 | 联宁（苏州）生物制药有限公司 | 药物偶联物，偶联方法，及其用途 |
| CN104688740A (zh) * | 2012-12-21 | 2015-06-10 | 百奥泰生物科技(广州)有限公司 | 类美登素衍生物及其制备方法和用途 |
| US9498532B2 (en) * | 2013-03-13 | 2016-11-22 | Novartis Ag | Antibody drug conjugates |
| MA38396B1 (fr) * | 2013-03-15 | 2019-05-31 | Novartis Ag | Anticorps medicamenteux conjugues et leurs compositions pharmaceutiques pour traiter un cancer positif a ckit |
| CN103254311B (zh) * | 2013-05-09 | 2015-05-13 | 齐鲁制药有限公司 | 一种制备抗体-美登素类生物碱药物偶联物的方法 |
| CN110177569A (zh) | 2017-03-30 | 2019-08-27 | 江苏恒瑞医药股份有限公司 | 抗体药物偶联物的制备方法 |
| CN110075315B (zh) * | 2018-01-26 | 2023-08-11 | 上海复旦张江生物医药股份有限公司 | 一种抗体偶联物及其制备方法和应用 |
| CN109652376B (zh) * | 2019-01-08 | 2021-10-15 | 创芯国际生物科技(广州)有限公司 | 一种用于卵巢癌组织3d培养的培养基 |
| US20220226334A1 (en) * | 2019-05-21 | 2022-07-21 | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | Antibody conjugate and application of pharmaceutical composition thereof |
| CN112691190A (zh) * | 2019-10-23 | 2021-04-23 | 东曜药业有限公司 | 抗体-高活性细胞毒小分子药物偶联药物及制备和应用 |
| CN113336823A (zh) * | 2021-05-28 | 2021-09-03 | 联宁（苏州）生物制药有限公司 | 一种用于抗体偶联药物连接子lnd1067的合成方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001024763A2 (en) * | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| WO2002098883A1 (en) * | 2001-05-31 | 2002-12-12 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| EP1354896A1 (en) * | 2000-12-28 | 2003-10-22 | Kirin Beer Kabushiki Kaisha | Novel monoclonal antibody |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US6531131B1 (en) * | 1999-08-10 | 2003-03-11 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for Neisseria meningitidis |
| US7097840B2 (en) * | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| AU2002332838B2 (en) * | 2001-09-05 | 2007-08-02 | Genentech, Inc. | Methods for the identification of polypeptide antigens associated with disorders involving aberrant cell proliferation and compositions useful for the treatment of such disorders |
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001024763A2 (en) * | 1999-10-01 | 2001-04-12 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| EP1354896A1 (en) * | 2000-12-28 | 2003-10-22 | Kirin Beer Kabushiki Kaisha | Novel monoclonal antibody |
| WO2002098883A1 (en) * | 2001-05-31 | 2002-12-12 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
Non-Patent Citations (1)
| Title |
|---|
| CHARI RAVI V.J. ET AL.; "Immunoconjugates containing novel maytansinoids: promising anticancer drugs"; Cancer Research, vol. 52, nr. 1, 1992, s. 127-131, ISSN 0008-5472., Dated: 01.01.0001 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101087611B (zh) | 2019-04-23 |
| ZA200601182B (en) | 2007-04-25 |
| CN101087611A (zh) | 2007-12-12 |
| NO20150450L (no) | 2006-04-21 |
| NO20160447A1 (no) | 2016-03-16 |
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