NO325989B1 - Anvendelse av leptin, i kombinasjon med en hemmer av VEGF og/eller angiogenese, for a hemme angiogenese. - Google Patents

Anvendelse av leptin, i kombinasjon med en hemmer av VEGF og/eller angiogenese, for a hemme angiogenese. Download PDF

Info

Publication number
NO325989B1
NO325989B1 NO20020920A NO20020920A NO325989B1 NO 325989 B1 NO325989 B1 NO 325989B1 NO 20020920 A NO20020920 A NO 20020920A NO 20020920 A NO20020920 A NO 20020920A NO 325989 B1 NO325989 B1 NO 325989B1
Authority
NO
Norway
Prior art keywords
leptin
angiogenesis
vegf
inhibitor
inhibitors
Prior art date
Application number
NO20020920A
Other languages
English (en)
Norwegian (no)
Other versions
NO20020920L (no
NO20020920D0 (no
Inventor
Batya Cohen
Menachem Rubinstein
Dalit Barkan
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13173999A external-priority patent/IL131739A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of NO20020920D0 publication Critical patent/NO20020920D0/no
Publication of NO20020920L publication Critical patent/NO20020920L/no
Publication of NO325989B1 publication Critical patent/NO325989B1/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/2264Obesity-gene products, e.g. leptin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/484Plasmin (3.4.21.7)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20020920A 1999-09-05 2002-02-25 Anvendelse av leptin, i kombinasjon med en hemmer av VEGF og/eller angiogenese, for a hemme angiogenese. NO325989B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL13173999A IL131739A0 (en) 1999-09-05 1999-09-05 Use of leptin in inhibition of endothelial cell proliferation
IL13231299A IL132312A0 (en) 1999-09-05 1999-10-10 Use of leptin in inhibition of endothelial cell proliferation
PCT/IL2000/000525 WO2001018040A2 (fr) 1999-09-05 2000-09-04 Utilisation de leptine en vue d'empecher la proliferation de la cellule endotheliale

Publications (3)

Publication Number Publication Date
NO20020920D0 NO20020920D0 (no) 2002-02-25
NO20020920L NO20020920L (no) 2002-05-03
NO325989B1 true NO325989B1 (no) 2008-09-01

Family

ID=26323878

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020920A NO325989B1 (no) 1999-09-05 2002-02-25 Anvendelse av leptin, i kombinasjon med en hemmer av VEGF og/eller angiogenese, for a hemme angiogenese.

Country Status (19)

Country Link
EP (1) EP1210108B1 (fr)
JP (1) JP2003508544A (fr)
KR (1) KR100683362B1 (fr)
CN (1) CN1189479C (fr)
AR (1) AR025494A1 (fr)
AT (1) ATE449609T1 (fr)
AU (1) AU781390B2 (fr)
BR (1) BR0013778A (fr)
CA (1) CA2382941C (fr)
DE (1) DE60043391D1 (fr)
EA (1) EA005066B1 (fr)
EE (1) EE05262B1 (fr)
ES (1) ES2335569T3 (fr)
HK (1) HK1048075B (fr)
IL (1) IL132312A0 (fr)
MX (1) MXPA02002448A (fr)
NO (1) NO325989B1 (fr)
UA (1) UA74163C2 (fr)
WO (1) WO2001018040A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355237B1 (en) * 1994-09-14 2002-03-12 Progenitor, Inc. Methods for using the obese gene and its gene product to stimulate hematopoietic development
US8633250B2 (en) * 2006-01-12 2014-01-21 Musc Foundation For Research Development Cell repair and regeneration by suramin and related polysulfonated napthylureas
CA2765847A1 (fr) * 2009-06-17 2010-12-23 National University Corporation Kumamoto University Agent prophylactique et/ou therapeutique pour dysmenorrhee

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997027286A1 (fr) * 1996-01-23 1997-07-31 Progenitor, Inc. Procedes d'utilisation du gene obese et de son produit genique afin de stimuler le developpement des cellules hematopoïetiques
IT1288388B1 (it) * 1996-11-19 1998-09-22 Angeletti P Ist Richerche Bio Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia
IL120733A0 (en) * 1997-04-29 1997-08-14 Yeda Res & Dev Leptin as an inhibitor of cell proliferation
WO1999059614A1 (fr) * 1998-05-20 1999-11-25 Yale University Modulation de l'angiogenese et de la cicatrisation

Also Published As

Publication number Publication date
NO20020920L (no) 2002-05-03
EP1210108A2 (fr) 2002-06-05
ES2335569T3 (es) 2010-03-30
JP2003508544A (ja) 2003-03-04
AR025494A1 (es) 2002-11-27
EP1210108B1 (fr) 2009-11-25
KR100683362B1 (ko) 2007-02-15
CN1377277A (zh) 2002-10-30
CN1189479C (zh) 2005-02-16
AU6862000A (en) 2001-04-10
HK1048075B (zh) 2005-07-29
NO20020920D0 (no) 2002-02-25
BR0013778A (pt) 2002-05-14
KR20020040781A (ko) 2002-05-30
EE200200116A (et) 2003-04-15
ATE449609T1 (de) 2009-12-15
CA2382941A1 (fr) 2001-03-15
IL132312A0 (en) 2001-03-19
WO2001018040A2 (fr) 2001-03-15
EA200200331A1 (ru) 2002-08-29
AU781390B2 (en) 2005-05-19
MXPA02002448A (es) 2002-07-30
EA005066B1 (ru) 2004-10-28
CA2382941C (fr) 2011-08-16
EE05262B1 (et) 2010-02-15
WO2001018040A3 (fr) 2001-06-14
UA74163C2 (uk) 2005-11-15
HK1048075A1 (en) 2003-03-21
DE60043391D1 (de) 2010-01-07

Similar Documents

Publication Publication Date Title
Franke et al. The NLRP3 inflammasome drives inflammation in ischemia/reperfusion injury after transient middle cerebral artery occlusion in mice
Bloch et al. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing
US20110104139A1 (en) ANGIOSTATIC COMPOSITIONS COMPRISING TRUNCATED TYROSYL-tRNA SYNTHETASE POLYPEPTIDES AND METHODS OF USING SAME
US5994292A (en) Interferon-inducible protein 10 is a potent inhibitor of angiogenesis
WO1998034634A1 (fr) Compositions et procedes destines a inhiber la proliferation cellulaire
BRPI0708791A2 (pt) medicamentos e proteÍnas
JP5400006B2 (ja) 虚血性疾患の予防または治療剤
US7261881B1 (en) Modulation of angiogenesis and wound healing
Ul-hasan et al. Expression of TGF-beta-1 mRNA and ultrastructural alterations in pharmacologically induced prolonged penile erection in a canine model
US20040001818A1 (en) Methods of inhibiting angiogenesis using NADPH oxidase inhibitors
NO325989B1 (no) Anvendelse av leptin, i kombinasjon med en hemmer av VEGF og/eller angiogenese, for a hemme angiogenese.
WO1999059614A1 (fr) Modulation de l'angiogenese et de la cicatrisation
CA2401096A1 (fr) Procedes et compositions permettant d'inhiber l'angiogenese
CA2494542A1 (fr) Prevention de lymphoedeme secondaire avec un adn de vegf-d
US20030054988A1 (en) Modified plasminogen related peptide fragments and their use as angiogenesis inhibitors
US8389476B2 (en) Parstatin peptides and uses thereof
ZA200201400B (en) Use of leptin in inhibition of endothelial cell proliferation.
CA2561841A1 (fr) Procedes permettant d'eliminer la neovascularisation au moyen de l'ephrine b2
AU1731300A (en) Compositions comprising angiostatin and kringle 5 region of plasminogen and methods of use thereof
US20040121955A1 (en) Methods for modulating angiogenesis
US7510714B2 (en) Methods for modulating angiogenesis
JPWO2002100441A1 (ja) 血管再生療法
WO2001089450A2 (fr) Traitement de pathologies musculosquelettiques par le polypeptide lp85 et des analogues de celui-ci
Mueller et al. Angiogenesis in endometriosis
CN111407881A (zh) 神经调节蛋白用于预防、治疗或延迟心肌损伤的方法和组合物

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees