NO316874B1 - Anvendelse av D-tagatose som en prebiotisk naering, naeringstilsetning eller naeringssupplement - Google Patents
Anvendelse av D-tagatose som en prebiotisk naering, naeringstilsetning eller naeringssupplement Download PDFInfo
- Publication number
- NO316874B1 NO316874B1 NO20004224A NO20004224A NO316874B1 NO 316874 B1 NO316874 B1 NO 316874B1 NO 20004224 A NO20004224 A NO 20004224A NO 20004224 A NO20004224 A NO 20004224A NO 316874 B1 NO316874 B1 NO 316874B1
- Authority
- NO
- Norway
- Prior art keywords
- tagatose
- butyrate
- production
- bacteria
- colon
- Prior art date
Links
- 235000013406 prebiotics Nutrition 0.000 title claims abstract description 14
- 235000015872 dietary supplement Nutrition 0.000 title claims description 5
- LKDRXBCSQODPBY-OEXCPVAWSA-N D-tagatose Chemical compound OCC1(O)OC[C@@H](O)[C@H](O)[C@@H]1O LKDRXBCSQODPBY-OEXCPVAWSA-N 0.000 claims abstract description 90
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims abstract description 73
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims abstract description 70
- 238000004519 manufacturing process Methods 0.000 claims abstract description 37
- 241000894006 Bacteria Species 0.000 claims abstract description 34
- 210000001072 colon Anatomy 0.000 claims abstract description 33
- 241000282414 Homo sapiens Species 0.000 claims abstract description 29
- 235000013305 food Nutrition 0.000 claims abstract description 11
- 230000012010 growth Effects 0.000 claims abstract description 11
- 206010009944 Colon cancer Diseases 0.000 claims abstract description 9
- 208000029742 colonic neoplasm Diseases 0.000 claims abstract description 9
- 229940079593 drug Drugs 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims abstract description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 14
- 241000186660 Lactobacillus Species 0.000 claims description 13
- 230000036541 health Effects 0.000 claims description 8
- 235000016709 nutrition Nutrition 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 239000004310 lactic acid Substances 0.000 claims description 7
- 235000014655 lactic acid Nutrition 0.000 claims description 7
- 230000002265 prevention Effects 0.000 claims description 6
- IJKRDVKGCQRKBI-UHFFFAOYSA-N Lactobacillinsaeure Natural products CCCCCCC1CC1CCCCCCCCCC(O)=O IJKRDVKGCQRKBI-UHFFFAOYSA-N 0.000 claims description 5
- IJKRDVKGCQRKBI-ZWKOTPCHSA-N lactobacillic acid Chemical compound CCCCCC[C@H]1C[C@H]1CCCCCCCCCC(O)=O IJKRDVKGCQRKBI-ZWKOTPCHSA-N 0.000 claims description 5
- 235000019219 chocolate Nutrition 0.000 claims description 4
- 235000009508 confectionery Nutrition 0.000 claims description 4
- 235000013618 yogurt Nutrition 0.000 claims description 4
- 235000015496 breakfast cereal Nutrition 0.000 claims description 3
- 235000015218 chewing gum Nutrition 0.000 claims description 3
- 229940112822 chewing gum Drugs 0.000 claims description 3
- 235000013373 food additive Nutrition 0.000 claims description 3
- 239000002778 food additive Substances 0.000 claims description 3
- 235000015243 ice cream Nutrition 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 229940126701 oral medication Drugs 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 235000021185 dessert Nutrition 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000010755 mineral Nutrition 0.000 claims description 2
- 230000009286 beneficial effect Effects 0.000 abstract description 6
- 230000003449 preventive effect Effects 0.000 abstract 1
- 235000021391 short chain fatty acids Nutrition 0.000 description 29
- 150000004666 short chain fatty acids Chemical class 0.000 description 29
- 241000282887 Suidae Species 0.000 description 22
- 235000005911 diet Nutrition 0.000 description 19
- 230000037213 diet Effects 0.000 description 19
- 238000011534 incubation Methods 0.000 description 17
- 238000000855 fermentation Methods 0.000 description 14
- 230000004151 fermentation Effects 0.000 description 14
- 238000010521 absorption reaction Methods 0.000 description 13
- 238000000338 in vitro Methods 0.000 description 12
- 241000282412 Homo Species 0.000 description 11
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 11
- 229930006000 Sucrose Natural products 0.000 description 11
- 239000008280 blood Substances 0.000 description 11
- 210000004369 blood Anatomy 0.000 description 11
- 230000000112 colonic effect Effects 0.000 description 11
- 239000005720 sucrose Substances 0.000 description 11
- 210000003608 fece Anatomy 0.000 description 10
- 230000000968 intestinal effect Effects 0.000 description 9
- 210000003240 portal vein Anatomy 0.000 description 8
- 230000006978 adaptation Effects 0.000 description 7
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 7
- 210000001035 gastrointestinal tract Anatomy 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 6
- 239000000835 fiber Substances 0.000 description 6
- 210000000936 intestine Anatomy 0.000 description 6
- 239000002002 slurry Substances 0.000 description 6
- 210000000813 small intestine Anatomy 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 230000006907 apoptotic process Effects 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 230000001965 increasing effect Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229920002472 Starch Polymers 0.000 description 4
- 201000011510 cancer Diseases 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 231100000673 dose–response relationship Toxicity 0.000 description 4
- 244000005706 microflora Species 0.000 description 4
- 210000004877 mucosa Anatomy 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 3
- 244000299461 Theobroma cacao Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 235000013365 dairy product Nutrition 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 210000000981 epithelium Anatomy 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 3
- KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical group CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 239000000845 maltitol Substances 0.000 description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 3
- 229940035436 maltitol Drugs 0.000 description 3
- 235000010449 maltitol Nutrition 0.000 description 3
- 230000001613 neoplastic effect Effects 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 210000000664 rectum Anatomy 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- WQZGKKKJIJFFOK-SVZMEOIVSA-N (+)-Galactose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-SVZMEOIVSA-N 0.000 description 2
- AEMOLEFTQBMNLQ-UHFFFAOYSA-N 3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound OC1OC(C(O)=O)C(O)C(O)C1O AEMOLEFTQBMNLQ-UHFFFAOYSA-N 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-M 3-Methylbutanoic acid Natural products CC(C)CC([O-])=O GWYFCOCPABKNJV-UHFFFAOYSA-M 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Natural products CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 235000016068 Berberis vulgaris Nutrition 0.000 description 2
- 241000335053 Beta vulgaris Species 0.000 description 2
- 241000305071 Enterobacterales Species 0.000 description 2
- 240000005979 Hordeum vulgare Species 0.000 description 2
- 235000007340 Hordeum vulgare Nutrition 0.000 description 2
- 229920000294 Resistant starch Polymers 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N beta-methyl-butyric acid Natural products CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000004067 bulking agent Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 210000004922 colonic epithelial cell Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000013325 dietary fiber Nutrition 0.000 description 2
- 210000002249 digestive system Anatomy 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 150000002016 disaccharides Chemical class 0.000 description 2
- 210000002919 epithelial cell Anatomy 0.000 description 2
- 235000012041 food component Nutrition 0.000 description 2
- 210000003405 ileum Anatomy 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 235000021590 normal diet Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 235000021254 resistant starch Nutrition 0.000 description 2
- 239000006152 selective media Substances 0.000 description 2
- 238000003307 slaughter Methods 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000001228 trophic effect Effects 0.000 description 2
- 229940070710 valerate Drugs 0.000 description 2
- XYHKNCXZYYTLRG-UHFFFAOYSA-N 1h-imidazole-2-carbaldehyde Chemical compound O=CC1=NC=CN1 XYHKNCXZYYTLRG-UHFFFAOYSA-N 0.000 description 1
- KVZLHPXEUGJPAH-UHFFFAOYSA-N 2-oxidanylpropanoic acid Chemical group CC(O)C(O)=O.CC(O)C(O)=O KVZLHPXEUGJPAH-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical group COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 241000606125 Bacteroides Species 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- RFSUNEUAIZKAJO-VRPWFDPXSA-N D-Fructose Natural products OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-VRPWFDPXSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000021068 Western diet Nutrition 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000003217 anti-cancerogenic effect Effects 0.000 description 1
- 230000002790 anti-mutagenic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000003613 bile acid Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000021152 breakfast Nutrition 0.000 description 1
- PASOAYSIZAJOCT-UHFFFAOYSA-N butanoic acid Chemical group CCCC(O)=O.CCCC(O)=O PASOAYSIZAJOCT-UHFFFAOYSA-N 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000003822 cell turnover Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 210000001100 crypt cell Anatomy 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 235000011850 desserts Nutrition 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000007407 health benefit Effects 0.000 description 1
- 235000021192 high fiber diet Nutrition 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000006317 isomerization reaction Methods 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 210000003550 mucous cell Anatomy 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000013310 pig model Methods 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000004767 rumen Anatomy 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- -1 short-chain fatty acid butyrate Chemical class 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 230000030968 tissue homeostasis Effects 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 239000000717 tumor promoter Substances 0.000 description 1
- 230000004222 uncontrolled growth Effects 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/30—Artificial sweetening agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- General Preparation And Processing Of Foods (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7569498P | 1998-02-24 | 1998-02-24 | |
PCT/DK1999/000074 WO1999043217A1 (en) | 1998-02-24 | 1999-02-23 | Use of d-tagatose as a prebiotic food component |
Publications (3)
Publication Number | Publication Date |
---|---|
NO20004224D0 NO20004224D0 (no) | 2000-08-23 |
NO20004224L NO20004224L (no) | 2000-10-23 |
NO316874B1 true NO316874B1 (no) | 2004-06-07 |
Family
ID=22127401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20004224A NO316874B1 (no) | 1998-02-24 | 2000-08-23 | Anvendelse av D-tagatose som en prebiotisk naering, naeringstilsetning eller naeringssupplement |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1056358B1 (de) |
JP (1) | JP2002504500A (de) |
KR (1) | KR100620477B1 (de) |
AT (1) | ATE241286T1 (de) |
AU (1) | AU742777B2 (de) |
BR (1) | BR9908221A (de) |
DE (1) | DE69908306T2 (de) |
DK (1) | DK1056358T3 (de) |
ES (1) | ES2198126T3 (de) |
NO (1) | NO316874B1 (de) |
PT (1) | PT1056358E (de) |
WO (1) | WO1999043217A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1151676B1 (de) * | 2000-05-01 | 2008-11-19 | Societe Des Produits Nestle S.A. | Herstellungsverfahren eines Getreideriegels |
US7189351B2 (en) * | 2001-10-25 | 2007-03-13 | Spherix Incorporated | D-tagatose as an anti-biofilm agent |
JP5749880B2 (ja) * | 2008-05-27 | 2015-07-15 | 松谷化学工業株式会社 | D−タガトースを有効成分とする体脂肪蓄積改善剤およびメタボリックシンドローム改善剤 |
KR101381794B1 (ko) | 2012-04-10 | 2014-04-07 | 씨제이제일제당 (주) | 타가토스 및 프로바이오틱 유산균을 함유하는 신바이오틱 식품 조성물 |
JP6475162B2 (ja) | 2012-09-11 | 2019-02-27 | ティラビスコ アーベー | プレバイオティックチラコイド組成物 |
KR101632687B1 (ko) * | 2013-01-14 | 2016-06-22 | 씨제이제일제당(주) | 타가토스를 함유하는 저지방 아이스크림용 조성물, 이를 이용한 저지방 아이스크림, 및 그 제조 방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4786722A (en) * | 1986-08-29 | 1988-11-22 | Biospherics Incorporated | D-tagatose as a low-calorie carbohydrate sweetener and bulking agent |
US5356879A (en) * | 1992-02-14 | 1994-10-18 | Biospherics, Incorporated | D-tagatose as anti-hyperglycemic agent |
JPH0665080A (ja) * | 1992-03-10 | 1994-03-08 | Godo Shiyusei Kk | α−グルコシダ−ゼ阻害剤を含有する、過血糖付随疾患の予防・治療剤、および保健食 |
-
1999
- 1999-02-23 AT AT99904733T patent/ATE241286T1/de not_active IP Right Cessation
- 1999-02-23 BR BR9908221-7A patent/BR9908221A/pt not_active Application Discontinuation
- 1999-02-23 PT PT99904733T patent/PT1056358E/pt unknown
- 1999-02-23 EP EP99904733A patent/EP1056358B1/de not_active Expired - Lifetime
- 1999-02-23 WO PCT/DK1999/000074 patent/WO1999043217A1/en not_active Application Discontinuation
- 1999-02-23 DE DE69908306T patent/DE69908306T2/de not_active Expired - Fee Related
- 1999-02-23 DK DK99904733T patent/DK1056358T3/da active
- 1999-02-23 KR KR1020007009292A patent/KR100620477B1/ko not_active IP Right Cessation
- 1999-02-23 AU AU25126/99A patent/AU742777B2/en not_active Ceased
- 1999-02-23 ES ES99904733T patent/ES2198126T3/es not_active Expired - Lifetime
- 1999-02-23 JP JP2000533025A patent/JP2002504500A/ja active Pending
-
2000
- 2000-08-23 NO NO20004224A patent/NO316874B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100620477B1 (ko) | 2006-09-13 |
WO1999043217A1 (en) | 1999-09-02 |
EP1056358B1 (de) | 2003-05-28 |
NO20004224D0 (no) | 2000-08-23 |
DE69908306T2 (de) | 2003-11-27 |
AU2512699A (en) | 1999-09-15 |
DE69908306D1 (de) | 2003-07-03 |
EP1056358A1 (de) | 2000-12-06 |
JP2002504500A (ja) | 2002-02-12 |
DK1056358T3 (da) | 2003-09-22 |
BR9908221A (pt) | 2000-10-24 |
ATE241286T1 (de) | 2003-06-15 |
KR20010034534A (ko) | 2001-04-25 |
ES2198126T3 (es) | 2004-01-16 |
AU742777B2 (en) | 2002-01-10 |
NO20004224L (no) | 2000-10-23 |
PT1056358E (pt) | 2003-10-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Livesey | The energy values of dietary fibre and sugar alcohols for man | |
US5840860A (en) | Fatty acid delivery system comprising a hydrolyzable bond | |
Velázquez et al. | E¡ ect of Oligosaccharides and Fibre Substitutes on Short-chain Fatty Acid Production by Human Faecal Microflora | |
Topping et al. | Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides | |
Kleessen et al. | Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons | |
RU2358741C2 (ru) | Композиции, обладающие функцией снижения жировой ткани тела, и продукты питания и напитки, содержащие такие композиции | |
EP1465505B1 (de) | Stimulation des immunsystems mit polydextrose | |
US5840705A (en) | α-glucosidase inhibitor, composition principally comprising sugar and containing the same, sweetener, food and feed | |
Murai et al. | Control of postprandial hyperglycaemia by galactosyl maltobionolactone and its novel anti-amylase effect in mice | |
EP2977052B1 (de) | Wirkstoff für erkrankungen im zusammenhang mit dem lebensstil und orale zusammensetzung damit | |
Ohkuma et al. | 44 Fibersol-2: a Soluble, Non-digestible, Starch-derived Dietary Fibre | |
JP2004524040A (ja) | 低下したグリセミック指数を持つ低カロリーバルク甘味料としてのフルクトースとラクトースとの混合物 | |
Lærke et al. | D-Tagatose has low small intestinal digestibility but high large intestinal fermentability in pigs | |
Caspary | Diarrhoea associated with carbohydrate malabsorption | |
EP3976051A1 (de) | Zusammensetzungen mit 2 -fucosyllactose und gos | |
Walton et al. | A double-blind, placebo controlled human study investigating the effects of coffee derived manno-oligosaccharides on the faecal microbiota of a healthy adult population | |
AU742777B2 (en) | Use of D-tagatose as a prebiotic food component | |
Tinker et al. | The effects of guar gum or wheat bran on the disappearance of 14C-labeled starch from the rat gastrointestinal tract | |
US7202219B1 (en) | Use of D-tagatose as a prebiotic food component | |
Sinaud et al. | Net energy value of two low-digestible carbohydrates, Lycasin® HBC and the hydrogenated polysaccharide fraction of Lycasin® HBC in healthy human subjects and their impact on nutrient digestive utilization | |
Nishiyama et al. | Mannitol lowers fat digestibility and body fat accumulation in both normal and cecectomized rats | |
JPH09104624A (ja) | α−グルコシダーゼ阻害剤、それを含む糖を主体とする組成物、甘味料、食品及び飼料 | |
Knapp | Select novel carbohydrates affect glycemic and insulinemic response, energy value, and indices of gut health as measured using canine, avian, rodent, and in vitro model systems | |
US20230189864A1 (en) | Non-therapeutic methods for maintaining a healthy body weight or losing body weight | |
Beynen | Beet pulp in dog food |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |