NO20091095L - Fremgangsmate og mellomprodukter for syntetisering av 2-(kinolin-5-yl)-4,5-disubstituerte azolderivater - Google Patents

Fremgangsmate og mellomprodukter for syntetisering av 2-(kinolin-5-yl)-4,5-disubstituerte azolderivater

Info

Publication number
NO20091095L
NO20091095L NO20091095A NO20091095A NO20091095L NO 20091095 L NO20091095 L NO 20091095L NO 20091095 A NO20091095 A NO 20091095A NO 20091095 A NO20091095 A NO 20091095A NO 20091095 L NO20091095 L NO 20091095L
Authority
NO
Norway
Prior art keywords
quinolin
intermediates
synthesis
azole derivatives
disubstituted azole
Prior art date
Application number
NO20091095A
Other languages
English (en)
Inventor
Jianguo Yin
Xiaoyong Fu
Shuyi Zhang
Michael R Reeder
Timothy D Cutarelli
Timothy L Mcallister
Kelvin H Yong
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of NO20091095L publication Critical patent/NO20091095L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ny fremgangsmåte for å syntetisere 2- (kinolin-5-yl)-4,5-disubstituerte azolderivater som kan anvendes f.eks. som PDE-IV-inhibitorforbindelser i farmasøytisk preparater.
NO20091095A 2006-08-14 2009-03-12 Fremgangsmate og mellomprodukter for syntetisering av 2-(kinolin-5-yl)-4,5-disubstituerte azolderivater NO20091095L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83756706P 2006-08-14 2006-08-14
US95925207P 2007-07-10 2007-07-10
PCT/US2007/017796 WO2008021235A2 (en) 2006-08-14 2007-08-10 Process and intermediates for the synthesis of 2-(quinolin-5-yl)-4,5 disubstituted-azole derivatives

Publications (1)

Publication Number Publication Date
NO20091095L true NO20091095L (no) 2009-05-12

Family

ID=38787609

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20091095A NO20091095L (no) 2006-08-14 2009-03-12 Fremgangsmate og mellomprodukter for syntetisering av 2-(kinolin-5-yl)-4,5-disubstituerte azolderivater

Country Status (12)

Country Link
US (1) US7985860B2 (no)
EP (3) EP2385050A1 (no)
JP (1) JP2010500405A (no)
KR (1) KR20090040378A (no)
AR (1) AR062361A1 (no)
AU (1) AU2007284688A1 (no)
BR (1) BRPI0715051A2 (no)
CA (1) CA2660736A1 (no)
CO (1) CO6160220A2 (no)
MX (1) MX2009001767A (no)
NO (1) NO20091095L (no)
WO (1) WO2008021235A2 (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5581219B2 (ja) 2008-01-25 2014-08-27 ミレニアム ファーマシューティカルズ， インコーポレイテッド チオフェンおよびホスファチジルイノシトール３−キナーゼ（ｐｉ３ｋ）阻害薬としてのその使用
US8796314B2 (en) 2009-01-30 2014-08-05 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
JP2012516329A (ja) 2009-01-30 2012-07-19 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｐｉ３ｋ阻害剤としてのヘテロアリールおよびその使用
US9090601B2 (en) 2009-01-30 2015-07-28 Millennium Pharmaceuticals, Inc. Thiazole derivatives
JP2013533318A (ja) 2010-08-11 2013-08-22 ミレニアム ファーマシューティカルズ， インコーポレイテッド ヘテロアリールおよびその使用
WO2012021611A1 (en) 2010-08-11 2012-02-16 Millennium Pharmaceuticals, Inc. Heteroaryls and uses thereof
AR082665A1 (es) 2010-08-11 2012-12-26 Millennium Pharm Inc Derivados heteroarilicos inhibidores de quinasas pi3k, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos proliferativos, inflamatorios y/o cardiovasculares
TW201307309A (zh) 2010-10-13 2013-02-16 Millennium Pharm Inc 雜芳基化合物及其用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100907354B1 (ko) * 2004-05-18 2009-07-10 쉐링 코포레이션 Ｐｄｅ4 억제제로서 유용한 치환된 2-퀴놀릴-옥사졸
BRPI0712915A2 (pt) * 2006-07-11 2012-10-09 Schering Corp sal de xinafoato de um composto de 5-oxazal-2-il-quinolina substituìdo

Also Published As

Publication number Publication date
US20080045718A1 (en) 2008-02-21
KR20090040378A (ko) 2009-04-23
EP2385051A1 (en) 2011-11-09
BRPI0715051A2 (pt) 2015-05-19
AR062361A1 (es) 2008-11-05
WO2008021235A3 (en) 2008-08-07
WO2008021235A2 (en) 2008-02-21
CO6160220A2 (es) 2010-05-20
AU2007284688A1 (en) 2008-02-21
JP2010500405A (ja) 2010-01-07
CA2660736A1 (en) 2008-02-21
US7985860B2 (en) 2011-07-26
EP2069284A2 (en) 2009-06-17
EP2385050A1 (en) 2011-11-09
MX2009001767A (es) 2009-02-25

Similar Documents

Publication Publication Date Title
NO20091095L (no) Fremgangsmate og mellomprodukter for syntetisering av 2-(kinolin-5-yl)-4,5-disubstituerte azolderivater
CY1117324T1 (el) Παραγωγα 1-φαινυλ-2-πυριδινυλ αλκυλ αλκοολων ως αναστολεις φωσφοδιεστερασης
NO20090628L (no) Pyridizinon derivativater
ATE522518T1 (de) Indazol- und isoindolderivate als glucokinaseaktivierende stoffe
EA200801428A1 (ru) Производные пиридиазинона для лечения опухолей
DE602007012589D1 (de) 4-ä4-Ä(ä3-TERT-BUTYL-1-Ä3-(HYDROXYMETHYL)-PHENYLÜ-1H-PYRAZOL-5-YLü-CARBAMOYL)-AMINOÜ-3-FLUOROPHENOXYü -N-METHYLPYRIDIN-2-CARBOXAMID SOWIE PRODRUGS UND
NO20071619L (no) Fremgangsmate for fremstilling av indazol forbindelse
NO20092692L (no) MAPK/ERK kinaseinhibitorer
AU2009236256A8 (en) Small molecule inhibitors of the pleckstrin homology domain and methods for using same
DK1934174T3 (da) Azetidiner som MEK inhibitorer til behandling af proliferative sygdomme
RS54457B1 (en) CRYSTAL (R) - (E) -2- (4- (2- (5- (1- (3,5-Dichloropyridin-4-yl) ethoxy) -1H-indazol-3-yl) vinyl) -1H- PIRAZOL-1-IL) ETHANOL AND ITS USE AS FGFR INHIBITOR
CY1113314T1 (el) (3-αρυλ-πιπεραζιν-1-υλ) παραγωγα της 6,7-διαλκοξυκιναζολινης, 6,7-διαλκοξυφθαλαζινης και 6,7-διαλκοξυϊσοκινολινης
PL1899329T3 (pl) Pirymidyno-podstawione pochodne benzimidazolu jako inhibitory kinaz białkowych
TW200714589A (en) Phenylacetamides suitable as protein kinase inhibitors
TN2010000131A1 (en) Polo-like kinase inhibitors
WO2009046842A3 (de) Thialzolderivate zur behandlung von krebs
NO20084923L (no) N-(2-thiazolyl)-amid derivater som GSK-3 inhibitorer
NO20091626L (no) MGLUR5-modulatorer
NO20082256L (no) Pyrazolderivater, preparater som inneholder slike forbindelser, og fremgangsmåter for anvendelse
MX2010002938A (es) Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
NZ579928A (en) Fluorinated derivatives of deferiprone
NO20063944L (no) Piperidinylkarbonyl-pyrrolidiner og deres anvendelse som melanokortinagonister
NO20064351L (no) Caspaseinhibitorer og anvendelser derav
WO2007097981A3 (en) Alpha carbolines and uses thereof
MA32727B1 (fr) Pyrazolylaminopyridines au titre d'inhibiteurs de fak

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application