NO20081376L - Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferens - Google Patents

Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferens

Info

Publication number
NO20081376L
NO20081376L NO20081376A NO20081376A NO20081376L NO 20081376 L NO20081376 L NO 20081376L NO 20081376 A NO20081376 A NO 20081376A NO 20081376 A NO20081376 A NO 20081376A NO 20081376 L NO20081376 L NO 20081376L
Authority
NO
Norway
Prior art keywords
nucleic acid
acid molecules
rna
gene expression
small nucleic
Prior art date
Application number
NO20081376A
Other languages
English (en)
Inventor
David Morrisey
James Mcswiggen
Leonid Beigelman
Original Assignee
Sirna Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/205,646 external-priority patent/US20080161256A1/en
Priority claimed from US11/234,730 external-priority patent/US20070270579A1/en
Priority claimed from US11/299,254 external-priority patent/US20060217331A1/en
Priority claimed from PCT/US2006/032168 external-priority patent/WO2007022369A2/en
Application filed by Sirna Therapeutics Inc filed Critical Sirna Therapeutics Inc
Publication of NO20081376L publication Critical patent/NO20081376L/no

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Sammendrag Foreliggende oppfinnelse gjelder forbindelser, preparater og fremgangsmåter for undersøkelse, diagnose og behandling av trekk, sykdommer og tilstander som responderer på modulering av genekspresjon og/eller genaktivitet. Foreliggende oppfinnelse er også rettet mot forbindelser, preparater og fremgangsmåter forbundet med trekk, sykdommer og tilstander som responderer på modulering av ekspresjonen og/eller aktiviteten av gener som deltar i genekspresjons-reaksjonsveier eller andre cellulære prosesser som fomiidler vedlikeholdelse eller utvikling av slike trekk, sykdommer og tilstander. Nærmere bestemt gjelder oppfinnelsen dobbelttrådede nukleinsyremolekyler, innbefattet små nukle insyremolekyler, for eksempel korte interfererende nukleinsyremolekyler (siNA), korte interfererende RNA-molekyler (siRNA), dobbelttrådede RNA-molekyler (dsRNA), mikro- RNA-molekyler (miRNA) og korte håmåls-RNA- molekyler (shRNA) som kan formidle RNAinterferens (RNAi) mot genekspresjon, innbefattet blandinger av slike små nukleinsyremolekyler og lipidnanopartikkel (LNP)-utforniinger av slike små nukleinsyremolekyler. Foreliggende oppfinnelse gjelder også små nukleinsyremolekyler, for eksempel siNA, siRNA og andre, som kan inhibere funksjonen av endogene RNA-molekyler, for eksempel endogent mikro-RNA (miRNA) (for eksempel miRNAinhibitorer) eller endogene, korte interfererende RNA (siRNA) (for eksempel siRNA-inhibitorer) eller som kan inhibere funksjonen av RISC (for eksempel RISCinhibitorer) for modulering av genekspresjon ved å interferere med den regulatoriske funksjonen av slike.
NO20081376A 2005-08-17 2008-03-14 Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferens NO20081376L (no)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11/205,646 US20080161256A1 (en) 2001-05-18 2005-08-17 RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US11/234,730 US20070270579A1 (en) 2001-05-18 2005-09-23 RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US73702405P 2005-11-15 2005-11-15
US11/299,254 US20060217331A1 (en) 2001-05-18 2005-12-08 Chemically modified double stranded nucleic acid molecules that mediate RNA interference
PCT/US2006/032168 WO2007022369A2 (en) 2005-08-17 2006-08-17 Chemically modified short interfering nucleic acid molecules that mediate rna interference

Publications (1)

Publication Number Publication Date
NO20081376L true NO20081376L (no) 2008-05-16

Family

ID=40328218

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081376A NO20081376L (no) 2005-08-17 2008-03-14 Kjemisk modifiserte, korte, interfererende nukleinsyremolekyler som medierer RNA-interferens

Country Status (6)

Country Link
JP (1) JP2009504190A (no)
BR (1) BRPI0614407A2 (no)
IL (1) IL189540A0 (no)
MX (1) MX2008002369A (no)
NO (1) NO20081376L (no)
NZ (1) NZ565712A (no)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8315398B2 (en) 2007-12-21 2012-11-20 Dts Llc System for adjusting perceived loudness of audio signals
JP5730508B2 (ja) * 2009-07-10 2015-06-10 アンジェスＭｇ株式会社 炎症性腸疾患の治療又は予防剤
US8538042B2 (en) 2009-08-11 2013-09-17 Dts Llc System for increasing perceived loudness of speakers
US9312829B2 (en) 2012-04-12 2016-04-12 Dts Llc System for adjusting loudness of audio signals in real time

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050233996A1 (en) * 2002-02-20 2005-10-20 Sirna Therapeutics, Inc. RNA interference mediated inhibition of hairless (HR) gene expression using short interfering nucleic acid (siNA)
AU2003207708A1 (en) * 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes

Also Published As

Publication number Publication date
BRPI0614407A2 (pt) 2009-08-18
JP2009504190A (ja) 2009-02-05
IL189540A0 (en) 2008-08-07
MX2008002369A (es) 2008-03-18
NZ565712A (en) 2011-09-30

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