NO20076297L - New compounds II - Google Patents

New compounds II

Info

Publication number
NO20076297L
NO20076297L NO20076297A NO20076297A NO20076297L NO 20076297 L NO20076297 L NO 20076297L NO 20076297 A NO20076297 A NO 20076297A NO 20076297 A NO20076297 A NO 20076297A NO 20076297 L NO20076297 L NO 20076297L
Authority
NO
Norway
Prior art keywords
halo
alkyl
heteroaryl
ocf
heterocycloalkyl
Prior art date
Application number
NO20076297A
Other languages
Norwegian (no)
Inventor
Niklas Plobeck
Helena Gyback
Markus Haeberlein
Catrin Jonasson
Jacob Kihlstrom
Hakan Molin
Andreas Svensson
Jenny Viklund
Ulrika Yngve
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of NO20076297L publication Critical patent/NO20076297L/en

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
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    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
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    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
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    • C07C65/32—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups
    • C07C65/40—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups containing singly bound oxygen-containing groups
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Forbindelse med formel 1, hvori Y = H, -OH, halo, -OCI-6alkyl, -C1-6a1kyl, de to sistnevnte eventuelt substituerte med halo, -CN, -OH, CF3, -NH2; RI = -C3-6 sykloalkyl, heterosykloalkyl, aryl, alkylaryl, heteroaryl, -C3-6-alkyl, eventuelt substituert med halo, -CN, -OH, CF3, -OCF3, -NH2, -CONH2; M= -C(O)-, -C(H2)-, -CH(ORa)-, -N(Ra)-, -S(O)r-, heteroaryl og en binding; hvori Ra= H eller CI-6alkyl og r = 0, 1 eller 2; R2 = H, halo, -CN, eller D = -C1-6alkyl, C3-6sykloalkyl, heterosykloalkyl, -N(CH3)2, aryl, alkylaryl, heteroaryl og heterosykliske grupper; hvor D er eventuelt substituert med G = halo, -NO2, -CN, -OH, CF3, -OCF3, -NH2, -CONH2, -COOH aryl, heteroaryl, heterosykliske grupper, -C1-6alkyl, -C1-6alkoksy, heterosykloalkyl og C1-6alkylkarboksylat; hvor D kan være bundet til G med L = -C(O)-, -S-, eller -S(O2)-; og G kan være ytterligere substituert med substituenter valgt fra halo, -NO2, -CN, -OH, -CH3, -OCH3, CF3, -OCF3, NH2, -CONH2, -COOH, C1-6 alkylkarboksylat; og R3 = -OH eller C1-6alkoksy.Compound of Formula 1 wherein Y = H, -OH, halo, -OCI-6alkyl, -C1-6alkyl, the latter two optionally substituted with halo, -CN, -OH, CF3, -NH2; R 1 = -C 3-6 cycloalkyl, heterocycloalkyl, aryl, alkylaryl, heteroaryl, -C 3-6 alkyl optionally substituted with halo, -CN, -OH, CF 3, -OCF 3, -NH 2, -CONH 2; M = -C (O) -, -C (H2) -, -CH (ORa) -, -N (Ra) -, -S (O) r-, heteroaryl and a bond; wherein R a = H or C 1-6 alkyl and r = 0, 1 or 2; R 2 = H, halo, -CN, or D = -C 1-6 alkyl, C 3-6 cycloalkyl, heterocycloalkyl, -N (CH 3) 2, aryl, alkylaryl, heteroaryl and heterocyclic groups; wherein D is optionally substituted with G = halo, -NO 2, -CN, -OH, CF 3, -OCF 3, -NH 2, -CONH 2, -COOH aryl, heteroaryl, heterocyclic groups, -C 1-6 alkyl, -C 1-6 alkoxy, heterocycloalkyl and C 1-6 alkyl carboxylate; wherein D may be bonded to G with L = -C (O) -, -S-, or -S (O2) -; and G may be further substituted with substituents selected from halo, -NO 2, -CN, -OH, -CH 3, -OCH 3, CF 3, -OCF 3, NH 2, -CONH 2, -COOH, C 1-6 alkyl carboxylate; and R 3 = -OH or C 1-6 alkoxy.

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