NO20076297L - New compounds II - Google Patents
New compounds IIInfo
- Publication number
- NO20076297L NO20076297L NO20076297A NO20076297A NO20076297L NO 20076297 L NO20076297 L NO 20076297L NO 20076297 A NO20076297 A NO 20076297A NO 20076297 A NO20076297 A NO 20076297A NO 20076297 L NO20076297 L NO 20076297L
- Authority
- NO
- Norway
- Prior art keywords
- halo
- alkyl
- heteroaryl
- ocf
- heterocycloalkyl
- Prior art date
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- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Forbindelse med formel 1, hvori Y = H, -OH, halo, -OCI-6alkyl, -C1-6a1kyl, de to sistnevnte eventuelt substituerte med halo, -CN, -OH, CF3, -NH2; RI = -C3-6 sykloalkyl, heterosykloalkyl, aryl, alkylaryl, heteroaryl, -C3-6-alkyl, eventuelt substituert med halo, -CN, -OH, CF3, -OCF3, -NH2, -CONH2; M= -C(O)-, -C(H2)-, -CH(ORa)-, -N(Ra)-, -S(O)r-, heteroaryl og en binding; hvori Ra= H eller CI-6alkyl og r = 0, 1 eller 2; R2 = H, halo, -CN, eller D = -C1-6alkyl, C3-6sykloalkyl, heterosykloalkyl, -N(CH3)2, aryl, alkylaryl, heteroaryl og heterosykliske grupper; hvor D er eventuelt substituert med G = halo, -NO2, -CN, -OH, CF3, -OCF3, -NH2, -CONH2, -COOH aryl, heteroaryl, heterosykliske grupper, -C1-6alkyl, -C1-6alkoksy, heterosykloalkyl og C1-6alkylkarboksylat; hvor D kan være bundet til G med L = -C(O)-, -S-, eller -S(O2)-; og G kan være ytterligere substituert med substituenter valgt fra halo, -NO2, -CN, -OH, -CH3, -OCH3, CF3, -OCF3, NH2, -CONH2, -COOH, C1-6 alkylkarboksylat; og R3 = -OH eller C1-6alkoksy.Compound of Formula 1 wherein Y = H, -OH, halo, -OCI-6alkyl, -C1-6alkyl, the latter two optionally substituted with halo, -CN, -OH, CF3, -NH2; R 1 = -C 3-6 cycloalkyl, heterocycloalkyl, aryl, alkylaryl, heteroaryl, -C 3-6 alkyl optionally substituted with halo, -CN, -OH, CF 3, -OCF 3, -NH 2, -CONH 2; M = -C (O) -, -C (H2) -, -CH (ORa) -, -N (Ra) -, -S (O) r-, heteroaryl and a bond; wherein R a = H or C 1-6 alkyl and r = 0, 1 or 2; R 2 = H, halo, -CN, or D = -C 1-6 alkyl, C 3-6 cycloalkyl, heterocycloalkyl, -N (CH 3) 2, aryl, alkylaryl, heteroaryl and heterocyclic groups; wherein D is optionally substituted with G = halo, -NO 2, -CN, -OH, CF 3, -OCF 3, -NH 2, -CONH 2, -COOH aryl, heteroaryl, heterocyclic groups, -C 1-6 alkyl, -C 1-6 alkoxy, heterocycloalkyl and C 1-6 alkyl carboxylate; wherein D may be bonded to G with L = -C (O) -, -S-, or -S (O2) -; and G may be further substituted with substituents selected from halo, -NO 2, -CN, -OH, -CH 3, -OCH 3, CF 3, -OCF 3, NH 2, -CONH 2, -COOH, C 1-6 alkyl carboxylate; and R 3 = -OH or C 1-6 alkoxy.
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SE0501058 | 2005-05-09 | ||
PCT/SE2006/000547 WO2006121390A2 (en) | 2005-05-09 | 2006-05-08 | Benzoic acid derivatives that are modulators or agonists of glyr |
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EP (1) | EP1890993A4 (en) |
JP (1) | JP2008540520A (en) |
KR (1) | KR20080015788A (en) |
CN (1) | CN101218201A (en) |
AR (1) | AR056339A1 (en) |
AU (1) | AU2006244709A1 (en) |
BR (1) | BRPI0610240A2 (en) |
CA (1) | CA2607938A1 (en) |
IL (1) | IL186852A0 (en) |
MX (1) | MX2007013879A (en) |
NO (1) | NO20076297L (en) |
TW (1) | TW200718684A (en) |
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EP2068871B1 (en) | 2006-09-25 | 2013-12-25 | PTC Therapeutics, Inc. | Hydroxylated 1,2,4-oxadiazole benzoic acid compounds, compositions thereof and the use for nonsense suppression |
JP2010100552A (en) * | 2008-10-22 | 2010-05-06 | Tosoh Corp | Method for producing 1,3,5-triazine compound |
TW201100398A (en) | 2009-03-31 | 2011-01-01 | Arqule Inc | Substituted indolo-pyridinone compounds |
JP5761971B2 (en) * | 2010-11-26 | 2015-08-12 | 興和株式会社 | Pyrazine derivatives having a bicyclic aryl ring or a bicyclic heteroaryl ring |
CN103142569B (en) * | 2013-02-27 | 2016-01-20 | 南京医科大学 | 2,6-diisopropyl benzoic acid and derivant thereof are as the application of neuroprotective |
CA2957785C (en) | 2014-08-11 | 2023-01-03 | Angion Biomedica Corporation | Cytochrome p450 inhibitors and uses thereof |
CN107531631B (en) | 2014-12-31 | 2021-09-03 | 安吉昂生物医药公司 | Methods and agents for treating diseases |
CN109942427B (en) * | 2019-04-17 | 2022-02-18 | 云南农业大学 | Monoterpene phenol derivative, and synthesis method and application thereof in pesticide |
CN114540844B (en) * | 2022-02-24 | 2024-02-20 | 青岛科技大学 | Preparation method of benzothiophene derivative under electrocatalytic action |
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BE795722A (en) * | 1972-02-24 | 1973-06-18 | Fabre Sa Pierre | NEW DERIVATIVES WITH ANTI-INFLAMMATORY AND ANTALGIC ACTIVITY |
DE2431360A1 (en) * | 1974-06-29 | 1976-01-15 | Castaigne Sa | O-Substd thymotic acid cpds - prepd by reacting thymotic acid with opt substd alkyl halide and hydrolysing resulting ester |
GB1493375A (en) * | 1974-09-20 | 1977-11-30 | Ici Ltd | Salicylanilide derivatives |
US4005218A (en) * | 1975-03-18 | 1977-01-25 | Janssen Pharmaceutica N.V. | Antiparasitic salicylanilide derivatives |
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BRPI0610240A2 (en) | 2012-09-25 |
CA2607938A1 (en) | 2006-11-16 |
ZA200709488B (en) | 2008-11-26 |
EP1890993A2 (en) | 2008-02-27 |
IL186852A0 (en) | 2008-02-09 |
US20090192190A1 (en) | 2009-07-30 |
EP1890993A4 (en) | 2010-09-08 |
KR20080015788A (en) | 2008-02-20 |
AU2006244709A1 (en) | 2006-11-16 |
WO2006121390A2 (en) | 2006-11-16 |
JP2008540520A (en) | 2008-11-20 |
CN101218201A (en) | 2008-07-09 |
AR056339A1 (en) | 2007-10-03 |
WO2006121390A8 (en) | 2007-11-15 |
WO2006121390A3 (en) | 2007-01-11 |
TW200718684A (en) | 2007-05-16 |
MX2007013879A (en) | 2008-01-24 |
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