NO20071277L - Preparation of lodixanol. - Google Patents

Preparation of lodixanol.

Info

Publication number
NO20071277L
NO20071277L NO20071277A NO20071277A NO20071277L NO 20071277 L NO20071277 L NO 20071277L NO 20071277 A NO20071277 A NO 20071277A NO 20071277 A NO20071277 A NO 20071277A NO 20071277 L NO20071277 L NO 20071277L
Authority
NO
Norway
Prior art keywords
lodixanol
preparation
crude product
iodixanol
triiodo
Prior art date
Application number
NO20071277A
Other languages
Norwegian (no)
Other versions
NO338295B1 (en
Inventor
Jan Cervenka
Khalid Hussain
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20043305A external-priority patent/NO20043305D0/en
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Priority to NO20071277A priority Critical patent/NO338295B1/en
Publication of NO20071277L publication Critical patent/NO20071277L/en
Publication of NO338295B1 publication Critical patent/NO338295B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Fremgangsmåte for produksjon av iodixanol ved å utføre en renseprosess av urenset produkt i et løsningsmiddel som omfatter l-metoksy-2-propanol. Det urensede produktet oppnås i vandig løsning fiia dimerisering av 5-acetamido-N,N'-bis(2,3-dihydroksypropyl)-2,4,6-triiod-isoftalamid (forbindelse A).A process for the production of iodixanol by performing a purification process of the crude product in a solvent comprising 1-methoxy-2-propanol. The crude product is obtained in aqueous solution by dimerization of 5-acetamido-N, N'-bis (2,3-dihydroxypropyl) -2,4,6-triiodo-isophthalamide (Compound A).

NO20071277A 2004-08-09 2007-03-08 Preparation of iodixanol. NO338295B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO20071277A NO338295B1 (en) 2004-08-09 2007-03-08 Preparation of iodixanol.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20043305A NO20043305D0 (en) 2004-08-09 2004-08-09 Preparation of lodixanol
PCT/NO2005/000287 WO2006016815A1 (en) 2004-08-09 2005-08-08 Preparation of iodixanol
NO20071277A NO338295B1 (en) 2004-08-09 2007-03-08 Preparation of iodixanol.

Publications (2)

Publication Number Publication Date
NO20071277L true NO20071277L (en) 2007-03-08
NO338295B1 NO338295B1 (en) 2016-08-08

Family

ID=38198606

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071277A NO338295B1 (en) 2004-08-09 2007-03-08 Preparation of iodixanol.

Country Status (1)

Country Link
NO (1) NO338295B1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO342021B1 (en) * 2005-07-29 2018-03-12 Ge Healthcare As Continuous crystallization process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9720969D0 (en) * 1997-10-02 1997-12-03 Nycomed Imaging As Process
ITMI20010773A1 (en) * 2001-04-11 2002-10-11 Chemi Spa PROCESS FOR THE PRODUCTION OF HIGH PURITY IOEXOLO

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO342021B1 (en) * 2005-07-29 2018-03-12 Ge Healthcare As Continuous crystallization process

Also Published As

Publication number Publication date
NO338295B1 (en) 2016-08-08

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Legal Events

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Representative=s name: ZACCO NORWAY AS, POSTBOKS 2003 VIKA