NO20063952L - Chemokin-inhibiterende piperazinderivater og deres anvendelse for a behandle multippel myelom - Google Patents

Chemokin-inhibiterende piperazinderivater og deres anvendelse for a behandle multippel myelom

Info

Publication number
NO20063952L
NO20063952L NO20063952A NO20063952A NO20063952L NO 20063952 L NO20063952 L NO 20063952L NO 20063952 A NO20063952 A NO 20063952A NO 20063952 A NO20063952 A NO 20063952A NO 20063952 L NO20063952 L NO 20063952L
Authority
NO
Norway
Prior art keywords
multiple myeloma
chemokine
inhibiting
piperazine derivatives
treat multiple
Prior art date
Application number
NO20063952A
Other languages
English (en)
Inventor
Richard Horuk
Sun Jin Choi
G David Roodman
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO20063952L publication Critical patent/NO20063952L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Foreliggende oppfinnelse gjelder piperazinderivater med formlene Ia, Ib, Ic og Id, hvori R1a, R1b, R2, R3, R4, R5, R6, R9, R10 og Y er som definert heri, og anvendelse derav for behandling av multippelt myelom.
NO20063952A 2004-02-06 2006-09-05 Chemokin-inhibiterende piperazinderivater og deres anvendelse for a behandle multippel myelom NO20063952L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54280904P 2004-02-06 2004-02-06
PCT/US2005/003580 WO2005077372A1 (en) 2004-02-06 2005-02-04 Chemokine inhibiting piperazine derivatives and their use to treat multiple myeloma

Publications (1)

Publication Number Publication Date
NO20063952L true NO20063952L (no) 2006-11-03

Family

ID=34860343

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063952A NO20063952L (no) 2004-02-06 2006-09-05 Chemokin-inhibiterende piperazinderivater og deres anvendelse for a behandle multippel myelom

Country Status (13)

Country Link
US (1) US20050192282A1 (no)
EP (1) EP1713483A1 (no)
JP (1) JP2007521339A (no)
KR (1) KR20070015379A (no)
CN (1) CN1938029A (no)
AU (1) AU2005212290A1 (no)
BR (1) BRPI0507500A (no)
CA (1) CA2554974A1 (no)
IL (1) IL177197A0 (no)
NO (1) NO20063952L (no)
RU (1) RU2006131787A (no)
WO (1) WO2005077372A1 (no)
ZA (1) ZA200607436B (no)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1968590A2 (en) * 2005-12-15 2008-09-17 SmithKline Beecham Corporation Novel compounds
WO2011104307A2 (en) * 2010-02-25 2011-09-01 Graffinity Pharmaceuticals Gmbh Ligands for antibody purification by affinity chromatography
AU2014291711B2 (en) 2013-07-18 2017-02-02 Novartis Ag Autotaxin inhibitors comprising a heteroaromatic ring-benzyl-amide-cycle core

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3324117A (en) * 1967-06-06 Carboxylic acid piperazides and process for their manufacture
DE2730174C2 (de) * 1977-07-04 1981-12-10 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren Aminobenzoesäurederivate und Arzneimittel enthaltend solche Aminobenzoesäurederivate
CN1030415A (zh) * 1987-02-20 1989-01-18 山之内制药株式会社 饱和的杂环碳酰胺衍生物和它的制备方法
FR2623808B1 (fr) * 1987-12-01 1990-03-09 Adir Nouveaux derives flavonoides (benzyl-4 piperazinyl-1)-2 oxo-2 ethylene substitues, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US5272175A (en) * 1992-05-20 1993-12-21 G. D. Searle & Co. Substituted tyrosyl diamide compounds
US5389645A (en) * 1992-08-13 1995-02-14 G. D. Searle & Co. Substituted tyrosyl diamine amide compounds
EP0610487B1 (de) * 1992-09-03 1999-11-10 Boehringer Ingelheim Pharma KG Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
FR2724656B1 (fr) * 1994-09-15 1996-12-13 Adir Nouveaux derives du benzopyranne, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US5573266A (en) * 1995-02-13 1996-11-12 Safe-T-Vans, Inc. Vehicle body lowering system
US6207665B1 (en) * 1997-06-12 2001-03-27 Schering Aktiengesellschaft Piperazine derivatives and their use as anti-inflammatory agents
IL151923A0 (en) * 2000-03-31 2003-04-10 Pfizer Prod Inc Novel piperazine derivatives

Also Published As

Publication number Publication date
ZA200607436B (en) 2009-04-29
WO2005077372A1 (en) 2005-08-25
CN1938029A (zh) 2007-03-28
EP1713483A1 (en) 2006-10-25
BRPI0507500A (pt) 2007-06-26
JP2007521339A (ja) 2007-08-02
US20050192282A1 (en) 2005-09-01
KR20070015379A (ko) 2007-02-02
IL177197A0 (en) 2006-12-10
AU2005212290A1 (en) 2005-08-25
RU2006131787A (ru) 2008-03-20
CA2554974A1 (en) 2005-08-25

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Legal Events

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