NO20045655L - Method of protecting endothelial and epithelial cells during chemotherapy - Google Patents
Method of protecting endothelial and epithelial cells during chemotherapyInfo
- Publication number
- NO20045655L NO20045655L NO20045655A NO20045655A NO20045655L NO 20045655 L NO20045655 L NO 20045655L NO 20045655 A NO20045655 A NO 20045655A NO 20045655 A NO20045655 A NO 20045655A NO 20045655 L NO20045655 L NO 20045655L
- Authority
- NO
- Norway
- Prior art keywords
- epithelial cells
- cells during
- during chemotherapy
- protecting endothelial
- endothelial
- Prior art date
Links
- 238000002512 chemotherapy Methods 0.000 title 1
- 210000002889 endothelial cell Anatomy 0.000 title 1
- 230000003511 endothelial effect Effects 0.000 title 1
- 210000002919 epithelial cell Anatomy 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108091034117 Oligonucleotide Proteins 0.000 abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 abstract 2
- 229940124276 oligodeoxyribonucleotide Drugs 0.000 abstract 2
- 230000001681 protective effect Effects 0.000 abstract 2
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Den foreliggende oppfirmelse er rettet på anvendelse av et beskyttende oligodeoksyribonukleotid til behandling av en pasient som gjermomgår behandling med et irrmiimundertrykkende middel. Oppfirmelsen er videre rettet på en farmasøytisk sammensetning som irmeholder en terapeutisk effektiv dose av et irmnimimdertrykkende middel og av et beskyttende oligodeoksyribonukleotid.The present invention is directed to the use of a protective oligodeoxyribonucleotide for the treatment of a patient undergoing treatment with an immunosuppressive agent. The invention is further directed to a pharmaceutical composition containing a therapeutically effective dose of an immunosuppressant and of a protective oligodeoxyribonucleotide.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38411402P | 2002-05-31 | 2002-05-31 | |
| US38743802P | 2002-06-11 | 2002-06-11 | |
| PCT/EP2003/005753 WO2003101468A1 (en) | 2002-05-31 | 2003-06-02 | Method for the protection of endothelial and epithelial cells during chemotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20045655L true NO20045655L (en) | 2004-12-27 |
Family
ID=29715309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20045655A NO20045655L (en) | 2002-05-31 | 2004-12-27 | Method of protecting endothelial and epithelial cells during chemotherapy |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1509235A1 (en) |
| JP (1) | JP2005527636A (en) |
| CN (1) | CN1304011C (en) |
| AU (1) | AU2003238189A1 (en) |
| CA (1) | CA2487171A1 (en) |
| EA (1) | EA008213B1 (en) |
| HR (1) | HRP20041213A2 (en) |
| IL (1) | IL165353A0 (en) |
| IS (1) | IS7548A (en) |
| MX (1) | MXPA04011941A (en) |
| NO (1) | NO20045655L (en) |
| NZ (1) | NZ536864A (en) |
| PL (1) | PL374402A1 (en) |
| RS (1) | RS102504A (en) |
| UA (1) | UA83628C2 (en) |
| WO (1) | WO2003101468A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20031714A1 (en) * | 2003-09-05 | 2005-03-06 | Gentium Spa | FORMATIONS FOR ANTITUMORAL ACTION. |
| DK2637672T3 (en) * | 2010-11-12 | 2018-10-22 | Gentium S R L | DEFIBROTID FOR USE IN PROPHYLAXY AND / OR TREATMENT OF GRAPHIC VERSUS HOST DISEASE (GVHD) |
| MX352085B (en) | 2012-06-22 | 2017-11-08 | Gentium S R L | Euglobulin-based method for determining the biological activity of defibrotide. |
| EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998048843A1 (en) * | 1997-04-28 | 1998-11-05 | Arsinur Burcoglu | Method of treating hiv infection and related secondary infections thereof |
-
2003
- 2003-06-02 JP JP2004508823A patent/JP2005527636A/en active Pending
- 2003-06-02 EA EA200401448A patent/EA008213B1/en not_active IP Right Cessation
- 2003-06-02 PL PL03374402A patent/PL374402A1/en not_active Application Discontinuation
- 2003-06-02 CA CA002487171A patent/CA2487171A1/en not_active Abandoned
- 2003-06-02 CN CNB038125013A patent/CN1304011C/en not_active Expired - Fee Related
- 2003-06-02 UA UA20041109654A patent/UA83628C2/en unknown
- 2003-06-02 WO PCT/EP2003/005753 patent/WO2003101468A1/en active Application Filing
- 2003-06-02 RS YU102504A patent/RS102504A/en unknown
- 2003-06-02 NZ NZ536864A patent/NZ536864A/en unknown
- 2003-06-02 AU AU2003238189A patent/AU2003238189A1/en not_active Abandoned
- 2003-06-02 EP EP03735516A patent/EP1509235A1/en not_active Withdrawn
- 2003-06-02 MX MXPA04011941A patent/MXPA04011941A/en unknown
-
2004
- 2004-11-23 IL IL16535304A patent/IL165353A0/en unknown
- 2004-11-24 IS IS7548A patent/IS7548A/en unknown
- 2004-12-27 HR HR20041213A patent/HRP20041213A2/en not_active Application Discontinuation
- 2004-12-27 NO NO20045655A patent/NO20045655L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| RS102504A (en) | 2006-12-15 |
| EA008213B1 (en) | 2007-04-27 |
| JP2005527636A (en) | 2005-09-15 |
| HRP20041213A2 (en) | 2006-04-30 |
| EA200401448A1 (en) | 2005-06-30 |
| WO2003101468A1 (en) | 2003-12-11 |
| PL374402A1 (en) | 2005-10-17 |
| UA83628C2 (en) | 2008-08-11 |
| IL165353A0 (en) | 2006-01-15 |
| CA2487171A1 (en) | 2003-12-11 |
| AU2003238189A1 (en) | 2003-12-19 |
| CN1655801A (en) | 2005-08-17 |
| NZ536864A (en) | 2008-08-29 |
| CN1304011C (en) | 2007-03-14 |
| MXPA04011941A (en) | 2005-07-26 |
| EP1509235A1 (en) | 2005-03-02 |
| IS7548A (en) | 2004-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |