NO20044882L - Acyl-4-carboxylphenylurea derivatives, their preparation and use - Google Patents

Acyl-4-carboxylphenylurea derivatives, their preparation and use

Info

Publication number
NO20044882L
NO20044882L NO20044882A NO20044882A NO20044882L NO 20044882 L NO20044882 L NO 20044882L NO 20044882 A NO20044882 A NO 20044882A NO 20044882 A NO20044882 A NO 20044882A NO 20044882 L NO20044882 L NO 20044882L
Authority
NO
Norway
Prior art keywords
derivatives
acyl
carboxylphenylurea
preparation
compounds
Prior art date
Application number
NO20044882A
Other languages
Norwegian (no)
Inventor
Alfons Enhsen
Andreas Herling
Elisabeth Defossa
Karl Schoenafinger
Thomas Klabunde
Karl-Ulrich Wendt
Dieter Kadereit
Hans-Joerg Burger
Erich Von Rodern
Jorg Rieke-Zapp
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of NO20044882L publication Critical patent/NO20044882L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/46—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylureas
    • C07C275/48—Y being a hydrogen or a carbon atom
    • C07C275/54—Y being a carbon atom of a six-membered aromatic ring, e.g. benzoylureas

Abstract

Det beskrives acyl-4-karboksyfenylurinstoffderivater samt deres fysiologisk godtagbare salter og fysiologisk fimksjonelle derivater. Forbindelsene har formel (I) der restene har de angitte betydninger. Det beskrives videre fysiologisk godtagbare salter samt fremgangsmåte for fremstilling av forbindelsene og saltene. Forbindelsene egner seg blant annet som anti-diabetika.Acyl-4-carboxyphenylurea derivatives as well as their physiologically acceptable salts and physiologically functional derivatives are disclosed. The compounds have formula (I) wherein the residues have the meanings specified. Further, physiologically acceptable salts are disclosed as well as methods for preparing the compounds and salts. The compounds are suitable, among other things, as anti-diabetics.

NO20044882A 2002-04-11 2004-11-09 Acyl-4-carboxylphenylurea derivatives, their preparation and use NO20044882L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10215907A DE10215907A1 (en) 2002-04-11 2002-04-11 Acyl-4-carboxyphenyl-urea derivatives, processes for their preparation and their use
PCT/EP2003/003251 WO2003084922A1 (en) 2002-04-11 2003-03-28 Acyl-4-carboxyphenylurea derivatives, method for production and use thereof

Publications (1)

Publication Number Publication Date
NO20044882L true NO20044882L (en) 2004-11-09

Family

ID=28684935

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20044882A NO20044882L (en) 2002-04-11 2004-11-09 Acyl-4-carboxylphenylurea derivatives, their preparation and use

Country Status (28)

Country Link
EP (1) EP1497262B1 (en)
JP (1) JP4328211B2 (en)
KR (1) KR20040097333A (en)
CN (1) CN1286805C (en)
AR (1) AR039403A1 (en)
AT (1) ATE476412T1 (en)
AU (1) AU2003216900A1 (en)
BR (1) BR0309242A (en)
CA (1) CA2481817A1 (en)
DE (2) DE10215907A1 (en)
EC (1) ECSP045347A (en)
HR (1) HRPK20040930B3 (en)
HU (1) HUP0500440A2 (en)
IL (1) IL164249A0 (en)
MA (1) MA26390A1 (en)
MX (1) MXPA04009468A (en)
NO (1) NO20044882L (en)
NZ (1) NZ535834A (en)
OA (1) OA12805A (en)
PA (1) PA8570901A1 (en)
PE (1) PE20040374A1 (en)
PL (1) PL371279A1 (en)
RU (1) RU2004133045A (en)
TN (1) TNSN04199A1 (en)
TW (1) TW200404762A (en)
UA (1) UA78040C2 (en)
UY (1) UY27761A1 (en)
WO (1) WO2003084922A1 (en)

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DE102007042154A1 (en) 2007-09-05 2009-03-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Arylsulfonylaminomethyphosphonsäure derivatives, their preparation and their use as medicaments
DE102007054497B3 (en) 2007-11-13 2009-07-23 Sanofi-Aventis Deutschland Gmbh New crystalline hydrate form of dodecanedioic acid 4-((2S,3R)-3-((S)-3-(4-fluoro-phenyl)-3-hydroxy-propyl)-2-(4-methoxy-phenyl)-4-oxo-azetidin-1-yl)-benzylamide ((2S,3R,4R,5R)-pentahydroxy-hexyl)-amide useful e.g. to treat hyperlipidemia
WO2010003624A2 (en) 2008-07-09 2010-01-14 Sanofi-Aventis Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof
WO2010068601A1 (en) 2008-12-08 2010-06-17 Sanofi-Aventis A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof
WO2011023754A1 (en) 2009-08-26 2011-03-03 Sanofi-Aventis Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
EP2582709B1 (en) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
EP2683702B1 (en) 2011-03-08 2014-12-24 Sanofi New substituted phenyl oxathiazine derivatives, method for their manufacture, medicines containing these compounds and their application
EP2683704B1 (en) 2011-03-08 2014-12-17 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683699B1 (en) 2011-03-08 2015-06-24 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120054A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120051A1 (en) 2011-03-08 2012-09-13 Sanofi Benzyl-oxathiazine derivates substituted with adamantane or noradamantane, medicaments containing said compounds and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2683701B1 (en) 2011-03-08 2014-12-24 Sanofi Oxathiazine derivatives substituted with benzyl or heteromethylene groups, method for their preparation, their usage as medicament, medicament containing same and its use
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Also Published As

Publication number Publication date
HRP20040930A2 (en) 2005-04-30
MXPA04009468A (en) 2005-01-25
TNSN04199A1 (en) 2007-03-12
NZ535834A (en) 2006-07-28
MA26390A1 (en) 2004-11-01
PL371279A1 (en) 2005-06-13
HUP0500440A2 (en) 2005-08-29
WO2003084922A8 (en) 2005-01-13
PE20040374A1 (en) 2004-07-20
AU2003216900A1 (en) 2003-10-20
TW200404762A (en) 2004-04-01
JP2005522480A (en) 2005-07-28
BR0309242A (en) 2005-02-09
UA78040C2 (en) 2007-02-15
EP1497262A1 (en) 2005-01-19
JP4328211B2 (en) 2009-09-09
EP1497262B1 (en) 2010-08-04
HRPK20040930B3 (en) 2006-09-30
OA12805A (en) 2006-07-11
CN1646485A (en) 2005-07-27
ATE476412T1 (en) 2010-08-15
DE10215907A1 (en) 2003-11-06
RU2004133045A (en) 2005-05-27
UY27761A1 (en) 2003-10-31
DE50312949D1 (en) 2010-09-16
ECSP045347A (en) 2004-11-26
IL164249A0 (en) 2005-12-18
AR039403A1 (en) 2005-02-16
CA2481817A1 (en) 2003-10-16
KR20040097333A (en) 2004-11-17
PA8570901A1 (en) 2003-11-12
CN1286805C (en) 2006-11-29
WO2003084922A1 (en) 2003-10-16

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