NO20026167L - Condensed cyclic compounds as modulators of nuclear hormone receptor function - Google Patents

Condensed cyclic compounds as modulators of nuclear hormone receptor function

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Publication number
NO20026167L
NO20026167L NO20026167A NO20026167A NO20026167L NO 20026167 L NO20026167 L NO 20026167L NO 20026167 A NO20026167 A NO 20026167A NO 20026167 A NO20026167 A NO 20026167A NO 20026167 L NO20026167 L NO 20026167L
Authority
NO
Norway
Prior art keywords
modulators
hormone receptor
cyclic compounds
receptor function
nuclear hormone
Prior art date
Application number
NO20026167A
Other languages
Norwegian (no)
Other versions
NO20026167D0 (en
Inventor
Mark Ernest Salvati
James Aaron Balog
Weifang Shan
Soren Giese
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20026167D0 publication Critical patent/NO20026167D0/en
Publication of NO20026167L publication Critical patent/NO20026167L/en

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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NO20026167A 2000-06-28 2002-12-20 Condensed cyclic compounds as modulators of nuclear hormone receptor function NO20026167L (en)

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000264876A (en) * 1998-09-10 2000-09-26 Sumitomo Chem Co Ltd Condensed heterocyclic ring compound
EP1299094A2 (en) * 2000-06-28 2003-04-09 Bristol-Myers Squibb Company Selective androgen receptor modulators and methods for their identification, design and use
US20030114420A1 (en) * 2000-06-28 2003-06-19 Salvati Mark E. Fused cyclic modulators of nuclear hormone receptor function
CN1395467A (en) * 2000-09-07 2003-02-05 美国拜尔公司 Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents
HUP0500096A3 (en) * 2001-12-19 2012-08-28 Bristol Myers Squibb Co Fused heterocyclic compounds and analogs thereof: modulators of nuclear hormone receptor function, process for producing them and pharmaceutical compositions containing them
DE10162375A1 (en) * 2001-12-19 2003-07-10 Bayer Ag Bicyclic N-aryl amides
BR0308494A (en) * 2002-03-18 2005-05-03 Pharmacia Corp Combination of an aldosterone receptor antagonist and a fbric acid derivative
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
CA2495383A1 (en) 2002-08-12 2004-02-26 Takeda Pharmaceutical Company Limited Fused benzene derivative and use
US7199125B2 (en) 2003-10-02 2007-04-03 Bristol-Myers Squibb Company Spiro-cyclic compounds useful as anti-inflammatory agents
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7417040B2 (en) 2004-03-01 2008-08-26 Bristol-Myers Squibb Company Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7625923B2 (en) * 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US8546451B2 (en) 2005-11-28 2013-10-01 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
ES2377667T3 (en) * 2006-02-10 2012-03-29 Janssen Pharmaceutica N.V. Heterocycles of bicyclic imidazole or thiadiazole useful as selective androgen receptor modulators
WO2008007664A1 (en) 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Bicyclic heterocyclic compound and use thereof
EP2334683B1 (en) 2008-08-29 2017-03-22 MSD Italia S.r.l. Saturated bicyclic heterocyclic derivatives as smo antagonists
US9624161B2 (en) 2009-02-23 2017-04-18 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
US9427418B2 (en) 2009-02-23 2016-08-30 Gtx, Inc. Estrogen receptor ligands and methods of use thereof

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* Cited by examiner, † Cited by third party
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NZ300739A (en) * 1994-12-22 2000-05-26 Ligand Pharm Inc Steroid receptor modulator compounds
EP0918774B9 (en) * 1996-06-27 2002-04-10 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
EP1299094A2 (en) * 2000-06-28 2003-04-09 Bristol-Myers Squibb Company Selective androgen receptor modulators and methods for their identification, design and use

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WO2002000653A3 (en) 2002-07-25
NZ523802A (en) 2005-11-25
EP1299385A2 (en) 2003-04-09
CA2413683A1 (en) 2002-01-03
NO20026167D0 (en) 2002-12-20
HUP0303165A3 (en) 2006-05-29
WO2002000653A2 (en) 2002-01-03
HUP0303165A2 (en) 2003-12-29
JP2004515462A (en) 2004-05-27
AU2002215609A1 (en) 2002-01-08
BR0111869A (en) 2003-09-23
MXPA02012563A (en) 2003-05-14

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