NO20021959D0 - Tetrahydrotiopyranephthalazinone derivatives as PDE4 inhibitors - Google Patents

Tetrahydrotiopyranephthalazinone derivatives as PDE4 inhibitors

Info

Publication number
NO20021959D0
NO20021959D0 NO20021959A NO20021959A NO20021959D0 NO 20021959 D0 NO20021959 D0 NO 20021959D0 NO 20021959 A NO20021959 A NO 20021959A NO 20021959 A NO20021959 A NO 20021959A NO 20021959 D0 NO20021959 D0 NO 20021959D0
Authority
NO
Norway
Prior art keywords
tetrahydrotiopyranephthalazinone
derivatives
pde4 inhibitors
pde4
inhibitors
Prior art date
Application number
NO20021959A
Other languages
Norwegian (no)
Other versions
NO20021959L (en
Inventor
Armin Hatzelmann
Daniela Bundschuh
Hans-Peter Kley
Geert Jan Sterk
Ivonne Johanna Van Der Laan
Hendrik Timmerman
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of NO20021959D0 publication Critical patent/NO20021959D0/en
Publication of NO20021959L publication Critical patent/NO20021959L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
NO20021959A 1999-10-25 2002-04-25 Tetrahydrotiopyranephthalazinone derivatives as PDE4 inhibitors NO20021959L (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99121243 1999-10-25
US20395000P 2000-05-12 2000-05-12
PCT/EP2000/010445 WO2001030777A1 (en) 1999-10-25 2000-10-24 Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors

Publications (2)

Publication Number Publication Date
NO20021959D0 true NO20021959D0 (en) 2002-04-25
NO20021959L NO20021959L (en) 2002-05-29

Family

ID=26153155

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021959A NO20021959L (en) 1999-10-25 2002-04-25 Tetrahydrotiopyranephthalazinone derivatives as PDE4 inhibitors

Country Status (20)

Country Link
US (2) US6544993B1 (en)
EP (1) EP1244654A1 (en)
JP (1) JP2003512466A (en)
KR (1) KR20020043238A (en)
CN (1) CN1146562C (en)
AU (1) AU781137B2 (en)
BR (1) BR0014990A (en)
CA (1) CA2388119A1 (en)
CZ (1) CZ20021457A3 (en)
EA (1) EA005856B1 (en)
HK (1) HK1047276A1 (en)
HR (1) HRP20020350A2 (en)
HU (1) HUP0203487A2 (en)
IL (1) IL148807A0 (en)
MX (1) MXPA02003581A (en)
NO (1) NO20021959L (en)
PL (1) PL354979A1 (en)
SK (1) SK7232002A3 (en)
TR (1) TR200201128T2 (en)
WO (1) WO2001030777A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0203487A2 (en) * 1999-10-25 2003-02-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydrothiopyran-phthalazinone derivatives as pde4 inhibitors and pharmaceutical compositions containing them
HUP0303193A3 (en) * 2001-02-15 2007-08-28 Altana Pharma Ag Phthalayinone-piperidino-derivatives as pde4 inhibitors and pharmaceutical compositions containing them
MXPA03009583A (en) 2001-04-25 2004-02-12 Altana Pharma Ag Novel phthalazinones.
US7022696B2 (en) * 2001-04-25 2006-04-04 Altana Pharma Ag Piperazino-derivatives and their use as PDE4 inhibitor
TWI347845B (en) * 2002-03-06 2011-09-01 Nycomed Gmbh Pharmaceutical compositions,combinations,and kits for the treatment of respiratory diseases and use of the same
WO2004017974A1 (en) 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-pyridazones and phthalazones as pde4 inhibitors
AU2003255376A1 (en) * 2002-08-10 2004-03-11 Altana Pharma Ag Piperidine-derivatives as pde4 inhibitors
PL373146A1 (en) * 2002-08-10 2005-08-22 Altana Pharma Ag Pyridazinone-derivatives as pde4 inhibitors
WO2004018450A1 (en) * 2002-08-10 2004-03-04 Altana Pharma Ag Piperidine-n-oxide-derivatives
EP1587512A2 (en) * 2003-01-14 2005-10-26 ALTANA Pharma AG Pde4 inhibitors for the treatment of neoplasms of lymphoid cells
JP4778449B2 (en) 2004-02-04 2011-09-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング 2- (Piperidin-4-yl) -4,5-dihydro-2H-pyridazin-3-one derivatives as PDE4 inhibitors
EP1716123A1 (en) * 2004-02-04 2006-11-02 Altana Pharma AG Pyridazinone derivatives and their use as pde4 inhibitors
EA017282B1 (en) * 2004-03-03 2012-11-30 Никомед Гмбх Hydroxy-6-heteroarylphenanthridine derivative and use thereof as pde4 inhibitor
EP2651417B1 (en) * 2010-12-16 2016-11-30 Calchan Limited Ask1 inhibiting pyrrolopyrimidine derivatives
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
JP6545148B2 (en) 2013-03-13 2019-07-17 フラットリー ディスカバリー ラブ，エルエルシー Pyridazinone compounds and methods for the treatment of cystic fibrosis

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9204808D0 (en) * 1992-03-04 1992-04-15 Rhone Poulenc Rorer Ltd Novel compositions of matter
CA2400368A1 (en) 1992-12-02 1994-06-09 Allen J. Duplantier Catechol diethers as selective pde iv inhibitors
DE19533975A1 (en) 1995-09-14 1997-03-20 Merck Patent Gmbh Arylalkyl diazinones
JP2001508078A (en) 1997-01-15 2001-06-19 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Phthalazinone
WO1999031071A1 (en) * 1997-12-15 1999-06-24 Byk Gulden Lomberg Chemische Fabrik Gmbh New phthalazinones
EP1042319B1 (en) 1997-12-15 2004-02-04 ALTANA Pharma AG Dihydrobenzofurans
AU3328499A (en) 1998-03-14 1999-10-11 Byk Gulden Lomberg Chemische Fabrik Gmbh Phthalazinone pde iii/iv inhibitors
HUP0203487A2 (en) * 1999-10-25 2003-02-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tetrahydrothiopyran-phthalazinone derivatives as pde4 inhibitors and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
KR20020043238A (en) 2002-06-08
CZ20021457A3 (en) 2002-07-17
AU781137B2 (en) 2005-05-05
EA200200381A1 (en) 2002-10-31
CA2388119A1 (en) 2001-05-03
MXPA02003581A (en) 2002-10-23
BR0014990A (en) 2002-06-18
EA005856B1 (en) 2005-06-30
NO20021959L (en) 2002-05-29
PL354979A1 (en) 2004-03-22
CN1382137A (en) 2002-11-27
US20030166655A1 (en) 2003-09-04
US6544993B1 (en) 2003-04-08
EP1244654A1 (en) 2002-10-02
JP2003512466A (en) 2003-04-02
AU1515101A (en) 2001-05-08
HK1047276A1 (en) 2003-02-14
HRP20020350A2 (en) 2004-02-29
US6846821B2 (en) 2005-01-25
TR200201128T2 (en) 2002-08-21
CN1146562C (en) 2004-04-21
WO2001030777A1 (en) 2001-05-03
SK7232002A3 (en) 2002-09-10
IL148807A0 (en) 2002-09-12
HUP0203487A2 (en) 2003-02-28

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application