NO172114C - Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte bifenyler - Google Patents
Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte bifenylerInfo
- Publication number
- NO172114C NO172114C NO901076A NO901076A NO172114C NO 172114 C NO172114 C NO 172114C NO 901076 A NO901076 A NO 901076A NO 901076 A NO901076 A NO 901076A NO 172114 C NO172114 C NO 172114C
- Authority
- NO
- Norway
- Prior art keywords
- bifenyles
- preparation
- therapeutic active
- active substituted
- analogy procedure
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 235000010290 biphenyl Nutrition 0.000 abstract 2
- 150000004074 biphenyls Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/006—Palladium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
- C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
- C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/26—Polyhydroxylic alcohols containing only six-membered aromatic rings as cyclic part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1782—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
- C07C45/305—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation with halogenochromate reagents, e.g. pyridinium chlorochromate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
- C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyrane Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3909378A DE3909378A1 (de) | 1989-03-22 | 1989-03-22 | Substituierte biphenyle |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO901076D0 NO901076D0 (no) | 1990-03-07 |
| NO901076L NO901076L (no) | 1990-09-24 |
| NO172114B NO172114B (no) | 1993-03-01 |
| NO172114C true NO172114C (no) | 1993-06-09 |
Family
ID=6376933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO901076A NO172114C (no) | 1989-03-22 | 1990-03-07 | Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte bifenyler |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5138090A (fi) |
| EP (1) | EP0388732B1 (fi) |
| JP (1) | JP2965610B2 (fi) |
| KR (1) | KR900014297A (fi) |
| CN (1) | CN1025674C (fi) |
| AT (1) | ATE104949T1 (fi) |
| AU (1) | AU628145B2 (fi) |
| CA (1) | CA2012572A1 (fi) |
| DD (1) | DD297803A5 (fi) |
| DE (2) | DE3909378A1 (fi) |
| DK (1) | DK0388732T3 (fi) |
| ES (1) | ES2052089T3 (fi) |
| FI (1) | FI901391A0 (fi) |
| HU (1) | HU204762B (fi) |
| IE (1) | IE901041L (fi) |
| IL (1) | IL93791A0 (fi) |
| NO (1) | NO172114C (fi) |
| NZ (1) | NZ232978A (fi) |
| PT (1) | PT93517A (fi) |
| ZA (1) | ZA902165B (fi) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU660132B2 (en) * | 1992-12-21 | 1995-06-08 | Bayer Aktiengesellschaft | Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridine |
| US5393780A (en) * | 1993-03-26 | 1995-02-28 | Fujirebio Inc. | 4-fluorobiphenyl derivatives |
| KR940021505A (ko) * | 1993-03-26 | 1994-10-19 | 후꾸야마 마사루 | 4-플루오로비페닐 유도체 |
| AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
| DE19741400A1 (de) * | 1997-09-19 | 1999-03-25 | Bayer Ag | Benzyl-biphenyle |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE759053A (fr) * | 1969-11-17 | 1971-05-17 | Thomae Gmbh Dr K | Nouveaux acides hydroxycrotoniques et procedes pour les fabriquer |
| US4567289A (en) * | 1979-08-17 | 1986-01-28 | Merck & Co., Inc. | Substituted pyranone inhibitors of cholesterol synthesis |
| EP0068038B1 (en) * | 1981-06-29 | 1985-09-25 | Merck & Co. Inc. | (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same |
| US4453005A (en) * | 1982-12-06 | 1984-06-05 | Merck Frosst Canada, Inc. | Process for preparing substituted phenylalkenoic acids |
| US4537906A (en) * | 1982-12-06 | 1985-08-27 | Merck Frosst Canada, Inc. | Substituted phenylalkenoic acids and esters |
| US4536515A (en) * | 1982-12-06 | 1985-08-20 | Merck Frosst Canada, Inc. | Substituted phenylalkenoic acids and esters |
| US4855321A (en) * | 1986-01-31 | 1989-08-08 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4772626A (en) * | 1986-01-31 | 1988-09-20 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4863957A (en) * | 1987-12-21 | 1989-09-05 | Rorer Pharmaceutical Corporation | Novel HMG-CoA reductase inhibitors |
| US5001128A (en) * | 1987-12-21 | 1991-03-19 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | HMG-COA reductase inhibitors |
| DE3818570A1 (de) * | 1988-06-01 | 1989-12-21 | Boehringer Mannheim Gmbh | Neue 6-substituierte-4-hydroxy-tetrahydro-pyran -2-on-derivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen |
| US4992429A (en) * | 1989-08-24 | 1991-02-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel HMG-COA reductase inhibitors |
-
1989
- 1989-03-22 DE DE3909378A patent/DE3909378A1/de not_active Withdrawn
-
1990
- 1990-02-24 CN CN90100959A patent/CN1025674C/zh not_active Expired - Fee Related
- 1990-02-27 US US07/486,050 patent/US5138090A/en not_active Expired - Fee Related
- 1990-03-07 NO NO901076A patent/NO172114C/no unknown
- 1990-03-09 ES ES90104509T patent/ES2052089T3/es not_active Expired - Lifetime
- 1990-03-09 EP EP90104509A patent/EP0388732B1/de not_active Expired - Lifetime
- 1990-03-09 DK DK90104509.6T patent/DK0388732T3/da active
- 1990-03-09 AT AT9090104509T patent/ATE104949T1/de not_active IP Right Cessation
- 1990-03-09 DE DE59005499T patent/DE59005499D1/de not_active Expired - Fee Related
- 1990-03-19 JP JP2067383A patent/JP2965610B2/ja not_active Expired - Lifetime
- 1990-03-19 IL IL93791A patent/IL93791A0/xx unknown
- 1990-03-19 NZ NZ232978A patent/NZ232978A/en unknown
- 1990-03-20 DD DD90338913A patent/DD297803A5/de unknown
- 1990-03-20 FI FI901391A patent/FI901391A0/fi not_active Application Discontinuation
- 1990-03-20 CA CA002012572A patent/CA2012572A1/en not_active Abandoned
- 1990-03-20 PT PT93517A patent/PT93517A/pt not_active Application Discontinuation
- 1990-03-21 AU AU52084/90A patent/AU628145B2/en not_active Ceased
- 1990-03-21 ZA ZA902165A patent/ZA902165B/xx unknown
- 1990-03-21 IE IE901041A patent/IE901041L/xx unknown
- 1990-03-21 HU HU901633A patent/HU204762B/hu not_active IP Right Cessation
- 1990-03-22 KR KR1019900003855A patent/KR900014297A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1045769A (zh) | 1990-10-03 |
| EP0388732B1 (de) | 1994-04-27 |
| KR900014297A (ko) | 1990-10-23 |
| FI901391A0 (fi) | 1990-03-20 |
| NO172114B (no) | 1993-03-01 |
| JPH02286648A (ja) | 1990-11-26 |
| HUT54969A (en) | 1991-04-29 |
| HU204762B (en) | 1992-02-28 |
| DE3909378A1 (de) | 1990-09-27 |
| EP0388732A3 (de) | 1991-03-06 |
| NO901076L (no) | 1990-09-24 |
| DE59005499D1 (de) | 1994-06-01 |
| IE901041L (en) | 1990-09-22 |
| ATE104949T1 (de) | 1994-05-15 |
| AU628145B2 (en) | 1992-09-10 |
| CA2012572A1 (en) | 1990-09-22 |
| AU5208490A (en) | 1990-09-27 |
| PT93517A (pt) | 1990-11-07 |
| EP0388732A2 (de) | 1990-09-26 |
| JP2965610B2 (ja) | 1999-10-18 |
| ZA902165B (en) | 1990-12-28 |
| US5138090A (en) | 1992-08-11 |
| DK0388732T3 (da) | 1994-08-29 |
| NO901076D0 (no) | 1990-03-07 |
| NZ232978A (en) | 1992-05-26 |
| ES2052089T3 (es) | 1994-07-01 |
| DD297803A5 (de) | 1992-01-23 |
| CN1025674C (zh) | 1994-08-17 |
| HU901633D0 (en) | 1990-06-28 |
| IL93791A0 (en) | 1990-12-23 |
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