NO166643C - Fremg.maate for fremst. av den hoeyredreiende, optiske isomer av diastereomer a av ym-09730, med kjem. navn (+)-2,6-dimethyl-4-(n-nitrofenyl)-1,4-dihydropyridin-3,5-dicarboxylsyre-3-(1-benzylpyrrolidin-3-yl)-ester-5-methylester. - Google Patents

Fremg.maate for fremst. av den hoeyredreiende, optiske isomer av diastereomer a av ym-09730, med kjem. navn (+)-2,6-dimethyl-4-(n-nitrofenyl)-1,4-dihydropyridin-3,5-dicarboxylsyre-3-(1-benzylpyrrolidin-3-yl)-ester-5-methylester.

Info

Publication number
NO166643C
NO166643C NO854062A NO854062A NO166643C NO 166643 C NO166643 C NO 166643C NO 854062 A NO854062 A NO 854062A NO 854062 A NO854062 A NO 854062A NO 166643 C NO166643 C NO 166643C
Authority
NO
Norway
Prior art keywords
ester
isoms
benzylpyrrolidin
dihydropyridine
diastereomer
Prior art date
Application number
NO854062A
Other languages
English (en)
Norwegian (no)
Other versions
NO166643B (no
NO854062L (no
Inventor
Kazuharu Tamazawa
Hideki Arima
Minoru Okada
Yasuo Isomura
Klaus K Schmiegel
James H Wikel
Original Assignee
Yamanouchi Pharma Co Ltd
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd, Lilly Co Eli filed Critical Yamanouchi Pharma Co Ltd
Publication of NO854062L publication Critical patent/NO854062L/no
Publication of NO166643B publication Critical patent/NO166643B/no
Publication of NO166643C publication Critical patent/NO166643C/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
NO854062A 1985-01-24 1985-10-14 Fremg.maate for fremst. av den hoeyredreiende, optiske isomer av diastereomer a av ym-09730, med kjem. navn (+)-2,6-dimethyl-4-(n-nitrofenyl)-1,4-dihydropyridin-3,5-dicarboxylsyre-3-(1-benzylpyrrolidin-3-yl)-ester-5-methylester. NO166643C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1205185 1985-01-24

Publications (3)

Publication Number Publication Date
NO854062L NO854062L (no) 1986-07-25
NO166643B NO166643B (no) 1991-05-13
NO166643C true NO166643C (no) 1991-08-21

Family

ID=11794796

Family Applications (1)

Application Number Title Priority Date Filing Date
NO854062A NO166643C (no) 1985-01-24 1985-10-14 Fremg.maate for fremst. av den hoeyredreiende, optiske isomer av diastereomer a av ym-09730, med kjem. navn (+)-2,6-dimethyl-4-(n-nitrofenyl)-1,4-dihydropyridin-3,5-dicarboxylsyre-3-(1-benzylpyrrolidin-3-yl)-ester-5-methylester.

Country Status (12)

Country Link
JP (1) JPS61267577A (enrdf_load_stackoverflow)
KR (1) KR900002342B1 (enrdf_load_stackoverflow)
CN (1) CN1023483C (enrdf_load_stackoverflow)
AT (1) AT390613B (enrdf_load_stackoverflow)
CA (1) CA1273931A (enrdf_load_stackoverflow)
DK (1) DK468385A (enrdf_load_stackoverflow)
ES (1) ES8607284A1 (enrdf_load_stackoverflow)
FI (1) FI83517C (enrdf_load_stackoverflow)
GR (1) GR852497B (enrdf_load_stackoverflow)
IT (1) IT1221762B (enrdf_load_stackoverflow)
MX (1) MX260A (enrdf_load_stackoverflow)
NO (1) NO166643C (enrdf_load_stackoverflow)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE399208T1 (de) 2000-08-01 2008-07-15 Kaneka Corp Neue carbonylreduktase, deren gen und verfahren zu dessen verwendung
KR100939347B1 (ko) 2005-07-20 2010-01-29 (주)카이로드 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법
CN101643469B (zh) * 2008-12-27 2012-11-21 武汉百科药物开发有限公司 一种盐酸巴尼地平的合成工艺
EP4382529A1 (en) 2022-12-07 2024-06-12 Bayer Consumer Care AG A process for preparing pure (3s)-pyrrolidin-3-ol and pure (3s)-pyrrolidin-3-ol hydrochloride

Also Published As

Publication number Publication date
IT8522489A0 (it) 1985-10-15
KR860005637A (ko) 1986-08-11
FI853697L (fi) 1986-07-25
NO166643B (no) 1991-05-13
AT390613B (de) 1990-06-11
IT1221762B (it) 1990-07-12
ES8607284A1 (es) 1986-05-16
ES547696A0 (es) 1986-05-16
GR852497B (enrdf_load_stackoverflow) 1986-02-18
DK468385D0 (da) 1985-10-14
MX260A (es) 1995-01-31
CN1023483C (zh) 1994-01-12
DK468385A (da) 1986-07-25
ATA297085A (de) 1989-11-15
FI83517B (fi) 1991-04-15
CA1273931A (en) 1990-09-11
FI853697A0 (fi) 1985-09-26
CN85107590A (zh) 1986-07-23
FI83517C (fi) 1991-07-25
JPS61267577A (ja) 1986-11-27
NO854062L (no) 1986-07-25
KR900002342B1 (ko) 1990-04-12

Similar Documents

Publication Publication Date Title
GB2164336B (en) 4-aryl-1,4-dihydropyridine-3,5-dicarboxylate derivatives
IL86335A0 (en) Enhancers for the transdermal flux of certain 1,4-dihydropyridine derivatives
NL990014I1 (nl) Methyl, isopropyl-4-(2,1,3-benzoxadiazool-4-yl)-2,6-dimethyl-1,4-dihydro pyridine-3,5-dicarboxylaat en farmaceutisch preparaat dat deze verbinding bevat.
DE69003906D1 (de) Triacetin enthaltende, langwirkende injizierbare Zusammensetzungen.
KR910018025A (ko) 약제로서 n-알킬화 1,4-디히드로피리딘디카르복실산 에스테르의 용도, 신규 화합물-및 그의 제조방법
NO166643C (no) Fremg.maate for fremst. av den hoeyredreiende, optiske isomer av diastereomer a av ym-09730, med kjem. navn (+)-2,6-dimethyl-4-(n-nitrofenyl)-1,4-dihydropyridin-3,5-dicarboxylsyre-3-(1-benzylpyrrolidin-3-yl)-ester-5-methylester.
FI862111A7 (fi) Foerfarande foer framstaellning av 2(n-bensyl-n-metylamino)-etylmetyl-2,6-dimetyl-4-(m-nitrofenyl) -1,4-dihydropyridin-3,5-dikarboxylat och dess hydrokloridsalt.
NL7711827A (nl) 1.4-dihydro-2.6-dimethyl-4-(3-nitrofenyl)- 3.5-pyridinedicarbonzuur-isopropyl-(2-pro- poxy-ethyl)ester, werkwijzen ter bereiding ervan, alsmede de toepassing als perifere vasodilatator.
DK165686A (da) 1,4-dihydropyridin-3,5-dicarboxylatderivater
ES551768A0 (es) Un procedimiento para la preparacion del isomero optico dextrogiro del diastereomero a del 2,6-dimetil-4-(m-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-(1-bencilpirrolidin-3-ilo) y 5-metilo
PT84566B (pt) Processo para a preparacao do novo composto com actividade optica (+)-1,4- -dihidro-2,6-dimetil-4-(3-nitrofenil)-piridina-3,5-dicarboxilato de 3-metil-5- -{3-(4,4-difenil-piperidil-1)-profilo} e de composicoes farmaceuticas que o contem
EP0260605A3 (en) Dihydropyridine-5-phosphonic acid cyclic ester
DK0525537T3 (da) Anvendelse af 1,4 dihydropyridiner til fremstilling af lægemiddel til behandling af neuropatier fremkaldt af diabetes mellitus
IT8320800A0 (it) 2,6-dimetil-3,5-bis-(1-adamantilossicarbonil)-4-(2-difluorometossifenil)-1,4-diidropiridina.
FI853574L (fi) Dihydropyridin -3,5-dikarboxylsyraesterderivat.
DK162442C (da) 3-(2-(furoyl)-5-(eventuelt substitueret)alkoxy-carbonyl-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridiner og farmaceutisk praeparat indeholdende saadanne forbindelser
FI854858L (fi) 1,4-dihydropyridinderivat, deras framstaellning och farmaceutiska preparat innehaollande desamma.
DK550683D0 (da) Racematet og den optiske (+)-isomer af den diastereomere alfa-form af 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylsyre-3-(1-benzyl-3-piperidyl)ester-5-methylester og salte deraf samt farmaceutiske praeparater indeholdende disse forbindelser
ATE126190T1 (de) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-5-
AU575946B2 (en) 1,4-dihydro-2,6-dimethyl-4-(substituted phenyl)- 3,5-dicarboxylate derivatives
SE8303617D0 (sv) 2,6-dimetyl-4-(2,3-diklorfenyl)-1,4-dihydropyridin-3,5-dikarboxylsyra-3-metylester-5-etylester
LV5477A3 (lv) 2,6-Dimetil-3,5-dikarbmetoski-4-(o-difluormetoksifenil)-1,4-dihidropiridina iegusanas panemiens
IT8620305A0 (it) Processo per la preparazione di 2-(n-benzil-n-metilammino)-etil-metil1,4-diidro-2,6-dimetil-4-(3-nitro fenil)-3,5-piridin-dicarbossilato cloridrato.
ATE93851T1 (de) 1,4-dihydropyridin-enantiomere.
RO91076A2 (ro) Procedeu de obtinere a 4-(2'-nitrofenil)-2,6-dimetil-3,5-dicarboximetoxi-1,4-dihidropiridinei

Legal Events

Date Code Title Description
MK1K Patent expired