NO165897B - PROGRAMMABLE CLUTCH CLOCK. - Google Patents
PROGRAMMABLE CLUTCH CLOCK. Download PDFInfo
- Publication number
- NO165897B NO165897B NO863055A NO863055A NO165897B NO 165897 B NO165897 B NO 165897B NO 863055 A NO863055 A NO 863055A NO 863055 A NO863055 A NO 863055A NO 165897 B NO165897 B NO 165897B
- Authority
- NO
- Norway
- Prior art keywords
- tartar
- hydroxy
- ethane
- ehdp
- agents
- Prior art date
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- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 claims description 27
- 150000003839 salts Chemical class 0.000 claims description 14
- 230000015572 biosynthetic process Effects 0.000 claims description 12
- 239000011575 calcium Substances 0.000 claims description 11
- 229910052791 calcium Inorganic materials 0.000 claims description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 9
- 239000008375 oral care agent Substances 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 3
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 2
- 230000002411 adverse Effects 0.000 claims 1
- 208000006558 Dental Calculus Diseases 0.000 description 21
- 239000000203 mixture Substances 0.000 description 18
- 229940034610 toothpaste Drugs 0.000 description 14
- 239000000606 toothpaste Substances 0.000 description 14
- 210000003298 dental enamel Anatomy 0.000 description 11
- 238000012360 testing method Methods 0.000 description 10
- -1 trisodium hydrogen salt Chemical class 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 8
- 239000003082 abrasive agent Substances 0.000 description 8
- 239000002253 acid Substances 0.000 description 6
- 239000002324 mouth wash Substances 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000001506 calcium phosphate Substances 0.000 description 4
- 229910000389 calcium phosphate Inorganic materials 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 239000004088 foaming agent Substances 0.000 description 4
- 239000001257 hydrogen Substances 0.000 description 4
- 229910052739 hydrogen Inorganic materials 0.000 description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- 239000000551 dentifrice Substances 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 150000003863 ammonium salts Chemical class 0.000 description 2
- 230000003698 anagen phase Effects 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 150000004687 hexahydrates Chemical class 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 229940051866 mouthwash Drugs 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 2
- JZLWSRCQCPAUDP-UHFFFAOYSA-N 1,3,5-triazine-2,4,6-triamine;urea Chemical compound NC(N)=O.NC1=NC(N)=NC(N)=N1 JZLWSRCQCPAUDP-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- MHUNPSARLCGSPP-UHFFFAOYSA-N CC.OP(=O)OP(O)(O)=O Chemical compound CC.OP(=O)OP(O)(O)=O MHUNPSARLCGSPP-UHFFFAOYSA-N 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000877 Melamine resin Polymers 0.000 description 1
- 240000005125 Myrtus communis Species 0.000 description 1
- 235000013418 Myrtus communis Nutrition 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 238000002441 X-ray diffraction Methods 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 229910052586 apatite Inorganic materials 0.000 description 1
- WXQWKYFPCLREEY-UHFFFAOYSA-N azane;ethanol Chemical class N.CCO.CCO.CCO WXQWKYFPCLREEY-UHFFFAOYSA-N 0.000 description 1
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 229940043256 calcium pyrophosphate Drugs 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229920003086 cellulose ether Polymers 0.000 description 1
- 239000013522 chelant Substances 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 239000000625 cyclamic acid and its Na and Ca salt Substances 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 210000004268 dentin Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013861 fat-free Nutrition 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000010794 food waste Substances 0.000 description 1
- 229960002737 fructose Drugs 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 229960001031 glucose Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 210000004283 incisor Anatomy 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229940045996 isethionic acid Drugs 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 150000002596 lactones Chemical class 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000007974 melamines Chemical class 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 235000019960 monoglycerides of fatty acid Nutrition 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 210000001581 salivary duct Anatomy 0.000 description 1
- 239000010672 sassafras oil Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229960001462 sodium cyclamate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-O triethanolammonium Chemical compound OCC[NH+](CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-O 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G04—HOROLOGY
- G04G—ELECTRONIC TIME-PIECES
- G04G15/00—Time-pieces comprising means to be operated at preselected times or after preselected time intervals
- G04G15/006—Time-pieces comprising means to be operated at preselected times or after preselected time intervals for operating at a number of different times
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Electric Clocks (AREA)
- Programmable Controllers (AREA)
- Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
- Selective Calling Equipment (AREA)
- Lock And Its Accessories (AREA)
Description
Munnpleiemidler for hemning av kalksten. Oral care agents for inhibition of calculus.
Nærværende oppfinnelse vedrorer munnpleiemidler som hemmer dan-nelse av tannsten. The present invention relates to oral care products which inhibit the formation of tartar.
Uttrykket "munnpleiemiddel" som her anvendt, angir et produkt som under den vanlige bruk blir tilbake i munnhulen i en tid tilstrekkelig til å komme i kontakt med i det vesentlige alle tannoverflater. Slike produkter er f.eks. tannpleiemidler, munnvannmidier, tabletter eller pastiller, og opplosninger for lokal anvendelse. The term "mouth care agent" as used here denotes a product which, during normal use, remains in the oral cavity for a time sufficient to come into contact with essentially all tooth surfaces. Such products are e.g. dentifrices, mouthwashes, tablets or lozenges, and solutions for local application.
Tannsten er en avsetning som danner seg på overflatene av tennene ved den gingivale grense. Supragingival tannsten viser seg hovedsakelig i områdene nær åpningene for salivakanalene, f.eks. på de linjuale overflater av de nedre fortenner og på de mot kinnet vendte overflater for forste og annen seksårsjeksler,• Tartar is a deposit that forms on the surfaces of the teeth at the gingival border. Supragingival calculus mainly appears in the areas near the openings for the salivary ducts, e.g. on the linear surfaces of the lower incisors and on the cheek-facing surfaces of the first and second molars,•
og på de bakre overflater av de bakerste jeksler. and on the posterior surfaces of the posterior molars.
Tannsten består av en uorganisk andel som stort sett er kalsiumfosfat anordnet i ethydroksyapatit krystallgitterstruktur lig-nende ben, emalje og dentin. En organisk andel er også til stede og består av avskallede epitelceller, leukocytter, mat-rester og forskjellige arter mikroorganismer. Tartar consists of an inorganic part which is mostly calcium phosphate arranged in a hydroxyapatite crystal lattice structure similar to bone, enamel and dentin. An organic part is also present and consists of desquamated epithelial cells, leukocytes, food residues and different species of microorganisms.
Ved utvikling av tannsten dannes en begynnende avsetning som stort sett er amorft kalsiumfosfat som fastlagt ved rontgen-analyse. Etter som tannsten utvikler seg ved en krystallveksts-fase blir den synlig hvit eller gulaktig i farge, med mindre flekker eller misfarget av et eller annet middel. Foruten å være synlig og uonsket fra et etisk standpunkt er tannstensav-setning en stadig kilde til irritasjon av tannkjottet og videre til gingivitis og andre sykdommer på tennenes bærende deler, During the development of tartar, an initial deposit is formed which is mostly amorphous calcium phosphate as determined by X-ray analysis. As calculus develops through a crystal growth phase, it becomes visibly white or yellowish in color, with minor staining or discolouration by some agent. Apart from being visible and undesirable from an ethical point of view, tartar deposition is a constant source of irritation to the gums and further to gingivitis and other diseases of the supporting parts of the teeth,
og irritasjon nedsetter vevenes motstandsevne overfor endogene og eksogene organismer. and irritation reduces the tissue's resistance to endogenous and exogenous organisms.
En rekke kjemiske og biologiske midler har vært foreslått for A number of chemical and biological agents have been proposed for
å hemme tannstensdannelse eller fjerne tannsten etter at den er dannet. Periodisk fjerning av tannsten ved tannlegen er selv-følgelig en rutinebehandling hos tannlegen. to inhibit tartar formation or remove tartar after it has formed. Periodic removal of tartar by the dentist is, of course, routine treatment at the dentist.
Det har generelt vært foreslått å hemme tannstensdannelse kjemisk ved chelering av kalsium som hindrer kalsiumfosfat-tannstens-prekursor i å danne og/eller nedbryte dannet tannsten ved å fjerne kalsium. En rekke cheleringsmidler, slik som etylen-diamin-tetraeddiksyre, nitrilotrieddiksyre og visse lactoner av sukkersyrer, har vært anvendt for dette formål. Imidlertid begrenser tannstens kjemiske likhet med tannstrukturen brukbar-heten av cheleringsmidler, da de mer effektive cheleringsmidler alvorlig kan skade tannstrukturen ved avkalkning, som det vises av Grossman, "Oral Surgery, Oral Medicine and Oran Patho-logy 7, 484 - 487 (1954)" og Draus og medarb . "Dental It has generally been proposed to inhibit tartar formation chemically by chelating calcium which prevents calcium phosphate tartar precursor from forming and/or breaking down formed tartar by removing calcium. A number of chelating agents, such as ethylenediaminetetraacetic acid, nitrilotriacetic acid and certain lactones of sugar acids, have been used for this purpose. However, the chemical similarity of tartar to the tooth structure limits the usefulness of chelating agents, as the more effective chelating agents can seriously damage the tooth structure by decalcification, as shown by Grossman, "Oral Surgery, Oral Medicine and Oran Pathology 7, 484-487 (1954) " and Draus et al. "Dental
Progress 3, nr. 2, 79 - 81 (1963)". Således har utviklingen Progress 3, No. 2, 79 - 81 (1963)". Thus has the development
av munnpleiemidler som effektivt hemmer tannsten ved kalsium-chelering vært hemmet av sikkerhetsbetraktninger. of oral care products that effectively inhibit tartar by calcium chelation has been hampered by safety considerations.
Det er nå blitt funnet at etan -1-hydroksy-l,1-difosfonsyre og vannopploselige salter av denne er i besiddelse av overraskende evne til å hemme utvikling av tannsten uten å fjerne kalk fra tannemaljen eller ellers skade tannstrukturen når den anvendes i blandinger som holdes innenfor angitte pH-grenser. It has now been found that ethane-1-hydroxy-1,1-diphosphonic acid and water-soluble salts thereof possess the surprising ability to inhibit the development of calculus without removing lime from the tooth enamel or otherwise damaging the tooth structure when used in mixtures such as kept within specified pH limits.
Nærværende oppfinnelse angår et munnpleiemiddel som her definert, som inneholder fra 0,01 til 10 vekts-% etan-l-hydroksy-1, 1-difosfonsyre eller et vannopploselig salt av denne, fortrinnsvis trinatriumsaltet, idet pH for midlet holdes innen området 5 - 11, fortrinnsvis 7 - 10, og eventuelt slipemiddel som er i det vesentlige fritt for vannopploselig kalsium. The present invention relates to an oral care agent as defined here, which contains from 0.01 to 10% by weight of ethane-1-hydroxy-1,1-diphosphonic acid or a water-soluble salt thereof, preferably the trisodium salt, the pH of the agent being kept within the range 5 - 11, preferably 7 - 10, and any abrasive which is essentially free of water-soluble calcium.
Etan-l-hydroksy-1,1-difosfonsyre har molekular formel Ethane-1-hydroxy-1,1-diphosphonic acid has molecular formula
CH^CtOH) (P03H2)2. (Ifolge nomenklatur ved radikaler kan syren også betegnes 1-hydroksyetylidendifosfonsyre). Det letteste krystallbare salt av denne syre oppnås når tre syrehydrogen-atomer erstattes med natrium. Folgelig er et foretrukket salt til bruk i munnpleiemidlet ifolge oppfinnelsen trinatrium-hydrogensalt som har strukturen: CH^CtOH) (PO 3 H 2 ) 2 . (According to the nomenclature for radicals, the acid can also be called 1-hydroxyethylidenediphosphonic acid). The most easily crystallizable salt of this acid is obtained when three acid hydrogen atoms are replaced by sodium. Consequently, a preferred salt for use in the oral care agent according to the invention is trisodium hydrogen salt which has the structure:
Denne forbindelse krystalliserer normalt som heksahydrat som taper noe vann under lufttorring og gir en blanding av heksa-og monohydrat med gjennomsnittlig 3 til 4 molekyler hydrata-sjonsvann. This compound normally crystallizes as hexahydrate which loses some water during air drying and gives a mixture of hexa- and monohydrate with an average of 3 to 4 molecules of water of hydration.
Skjont ethvert alkalimetall, ammonium eller substituert ammon-iumsalt av etan-l-hydroksy-1,1-difosfonsyre kan brukes ved ut-førelsen av oppfinnelsen, er tetranatriumsalt, trinatrium-hydrogensalt, dinatrium-dihydrogensalt, mononatriumtrihydrogen-salt, og blandinger av disse foretrukket. De andre natrium-, kalium-, ammonium- og mono-, di- og trietanolammoniumsalter og blandinger av disse er også egnet. Although any alkali metal, ammonium or substituted ammonium salt of ethane-1-hydroxy-1,1-diphosphonic acid may be used in the practice of the invention, tetrasodium salt, trisodium hydrogen salt, disodium dihydrogen salt, monosodium trihydrogen salt, and mixtures thereof preferred. The other sodium, potassium, ammonium and mono-, di- and triethanol ammonium salts and mixtures thereof are also suitable.
I den folgende beskrivelse betegnes etan-hydroksy-difosfonsyre som EHDP, hvilket uttrykk har til hensikt å angi såvel syreformen som alle de vannopploselige salter av denne. Når formen til EHDP ikke er angitt, betyr % EHDP prosentandelen av trinatrium-hydrogen EHDP og de molare ekvivalenter av den frie syre og andre vannopploselige salter. In the following description, ethane-hydroxy-diphosphonic acid is referred to as EHDP, which term is intended to indicate both the acid form and all the water-soluble salts thereof. When the form of EHDP is not stated, % EHDP means the percentage of trisodium hydrogen EHDP and the molar equivalents of the free acid and other water-soluble salts.
Konsentrasjon av EHDP i munnpleiemidlene etter nærværende oppfinnelse kan være 0,01 % til 10 vektsprosent. Munnpleiemidler som ved den vanlige bruk tilfeldigvis vil svelges i vesentlige mengder, skal inneholde lavere konsentrasjoner av EHDP. Således inneholder et munnvann i overensstemmelse med nærværende oppfinnelse fortrinnsvis mindre enn ca. 3 % og tabletter og tyggegummi mindre enn ca. 1 vekts-% EHDP. Tannpleiemidler og opplosninger for lokal anvendelse, hvor sistnevnte administreres profesjonelt kan inneholde opptil ca. 10 vekts-%, fortrinnsvis fra 0,1 til 5,0 vekts-% EHDP. Concentration of EHDP in the oral care products according to the present invention can be 0.01% to 10% by weight. Oral care products which, during normal use, will accidentally be swallowed in significant quantities, must contain lower concentrations of EHDP. Thus, a mouthwash in accordance with the present invention preferably contains less than approx. 3% and tablets and chewing gum less than approx. 1 wt% EHDP. Dental care products and solutions for local use, where the latter is administered professionally, can contain up to approx. 10% by weight, preferably from 0.1 to 5.0% by weight EHDP.
pH for blandinger etter nærværende oppfinnelse kan være fra 5,0 til 11. Under pH 5,0 kan skade på tannemaljen opptre til tross for det relativt sikre EHDP. Over pH 11,0 oppstår van-skeligheter i å sammensette produkter som har tilfredsstillende smak og mildhet. Et foretrukket pH-område er fra 7,0 til 10. Munnpleiemidlets pH-verdi bestemmer naturligvis omfanget av noytralisasjonen av EHDP. The pH for mixtures according to the present invention can be from 5.0 to 11. Below pH 5.0, damage to the tooth enamel can occur despite the relatively safe EHDP. Above pH 11.0, difficulties arise in putting together products that have a satisfactory taste and mildness. A preferred pH range is from 7.0 to 10. The mouth care agent's pH value naturally determines the extent of the neutralization of EHDP.
Skjont det ikke tilsiktes at nærværende oppfinnelse begrenses Although it is not intended that the present invention be limited
av en spesiell teori, er det blitt iakttatt at EHDP forstyrrer utviklingen av tannstendannelse fra amorft kalsiumfosfat gjen-nom krystallvekstfasen til kalsium-hydroksyapanit. Mengder av EHDP som er langt for små til å chelere noen vesentlige mengder av kalsium er blitt funnet å hemme dannelsen av kalsiumhydroksy- of a particular theory, it has been observed that EHDP interferes with the development of tartar formation from amorphous calcium phosphate through the crystal growth phase of calcium hydroxyapanite. Amounts of EHDP that are far too small to chelate any significant amounts of calcium have been found to inhibit the formation of calcium hydroxy-
apatit. Denne selektive virkning på dannelsen av tannstensavsetninger uten avmineralisering på tannemaljen er overraskende. apatite. This selective effect on the formation of tartar deposits without demineralization of the tooth enamel is surprising.
Effektivitet av midlene etter nærværende oppfinnelse i å fore-bygge tannsten ble vist ved Rottetannstensproven som ble utfort som folger: To grupper 20 til 21 dagers gamle rotter av stammen Holtsman-Sprague-Dawley, hvor hver gruppe består av et handyr og et hun-dyr fra hvert av 10 kull, ble anvendt ved denne prove, og den ene gruppe tjener som kontroll- og den annen som provegruppe. Begge dyregrupper ble foret med en tannstensfremkallende diet bestående av 62 % maisstivelse, 32 % ikke fet torrmelk, 2 % leverpulver og 3 % cellulosemel. Lokale anvendelser av en 0,5 % vandig opplosning av trinatrium-hydrogen-etan-l-hydroksy-1, 1-difosfonat justert til pH 10,0 ble anbragt på tennene til hver av dyrene i prbvegruppen to ganger daglig i 3 uker. Lig-nende påforinger av vann ble gjort på hvert dyr i kontrollgrup-pen under eksperimentsperioden. 3 uker etter begynnelsen av proven ble dyrene avlivet og deres jeksler ble gradert med hensyn til tannstensdannelse ved å undersoke områdene og dybden av akkumuleringen på hver av de 44 tannoverflater som ble undersokt i hvert dyr. Gradering ble gjort etter en skala på 0 - 3 for hver overflate. 0 er ingen påviselig kalkavsetning, 3 er dekning av vesentlig 100 % av overflaten med en tykk avsetning og de mellomliggende verdier respresenterer graderinger mellom disse grenser. Den totale tannstensberegning for hvert dyr ble bestemt ved å addere grade-ringene for hver av de 44 overflater. Effectiveness of the agents according to the present invention in preventing calculus was shown by the Rat Tartar Test which was carried out as follows: Two groups of 20 to 21 day old rats of the Holtsman-Sprague-Dawley strain, each group consisting of a male animal and a female animal from each of 10 litters, was used in this test, and one group serves as control and the other as test group. Both animal groups were fed a calculus-inducing diet consisting of 62% corn starch, 32% non-fat dry milk, 2% liver powder and 3% cellulose flour. Topical applications of a 0.5% aqueous solution of trisodium hydrogen ethane-1-hydroxy-1,1-diphosphonate adjusted to pH 10.0 were placed on the teeth of each of the animals in the test group twice daily for 3 weeks. Similar applications of water were made to each animal in the control group during the experimental period. 3 weeks after the start of the test, the animals were sacrificed and their molars were graded for calculus formation by examining the areas and depth of accumulation on each of the 44 tooth surfaces examined in each animal. Grading was done on a scale of 0 - 3 for each surface. 0 is no detectable lime deposit, 3 is coverage of substantially 100% of the surface with a thick deposit and the intermediate values represent gradations between these limits. The total calculus count for each animal was determined by adding the grade rings for each of the 44 surfaces.
Resultatene som oppnås i to eksperimenter er angitt i tabellen nedenfor. The results obtained in two experiments are given in the table below.
Det kan sees at vesentlige reduksjoner i tannstensdannelse oppnås med lokalt påforte munnpleiemidler ifolge nærværende oppfinnelse. It can be seen that significant reductions in tartar formation are achieved with locally applied oral care agents according to the present invention.
Sikkerheten for EHDP for anvendelse i kontakt med tannoverflåt-ene ble bestemt ved en kontinuerlig neddykningsprove som ut-fores som folger: Naturlige menneskelige tenner ble neddykket i vandige oppløsninger som inneholder 3 % EHDP ved pH 7,0 og pH 10. Hver fjerde time ble tennene undersokt på avkalkning. The safety of EHDP for use in contact with tooth surfaces was determined by a continuous immersion test performed as follows: Natural human teeth were immersed in aqueous solutions containing 3% EHDP at pH 7.0 and pH 10. Every four hours, teeth examined for decalcification.
I synlig lys kan emaljeavkalkning oppdages ved tap av glans, hvite opake punkter eller svake ruheter i overflatene. Tennene ble undersokt makroskopisk og mikroskopisk ved utlopet av 7 dager. Ingen avkalkning ble iakttatt under denne periode, som angir at disse blandinger forårsaker ingen skade på tannemaljen. In visible light, enamel decalcification can be detected by loss of gloss, white opaque points or slight roughness in the surfaces. The teeth were examined macroscopically and microscopically at the end of 7 days. No decalcification was observed during this period, indicating that these mixtures cause no damage to tooth enamel.
Et tannpleiemiddel, særlig tannpasta som inneholder EHDP er en foretrukket utforelsesform for nærværende oppfinnelse. Tann-pastablandinger inneholder vanligvis slipende materialer, skum-mende midler, bindemidler, fuktemidler, smak- og sotningsmidler. A dentifrice, particularly toothpaste containing EHDP is a preferred embodiment of the present invention. Toothpaste mixtures usually contain abrasive materials, foaming agents, binding agents, wetting agents, flavoring and sooting agents.
Slipematerialene og andre hjelpemidler som anvendes i tannpleiemidler ifolge nærværende oppfinnelse er fortrinnsvis i det vesentlig fri for opploselig kalsium, slik at den sekvesterende eller krystallveksthemmende evne for EHDP ikke reduseres i slik grad at dens anti-tannstensvirkning svekkes. Således brukes vanlige slipemidler som dikalsium-ortofosfat og kalsiumkarbonat fortrinnsvis ikke. Imidlertid kan overveiende p -fase kalsium-pyrofosfat som fremstilles i overensstemmelse med US-patent The abrasive materials and other auxiliaries used in dental care products according to the present invention are preferably essentially free of soluble calcium, so that the sequestering or crystal growth-inhibiting ability of EHDP is not reduced to such an extent that its anti-tartar effect is weakened. Thus, common abrasives such as dicalcium orthophosphate and calcium carbonate are preferably not used. However, predominantly p-phase calcium pyrophosphate which is prepared in accordance with US Pat
nr. 3.112.247, hvilket inneholder relativt lite opploselig kalsium, anvendes. En spesiell foretrukket klasse av slipemidler for anvendelse her er de partikkelformede termoherdende polyme-riserte harpikser, som er beskrevet i US-patent nr. 3.070.510. Egnede harpikser omfatter melaminer, fenolharpikser, urea, melamin-urea, kryss-bundne epoksyder og kryss-bundne polyestere. No. 3,112,247, which contains relatively little soluble calcium, is used. A particularly preferred class of abrasives for use herein are the particulate thermosetting polymerized resins described in US Patent No. 3,070,510. Suitable resins include melamines, phenolic resins, urea, melamine-urea, cross-linked epoxies and cross-linked polyesters.
Andre egnede slipemidler omfatter aluminiumoksyd og de uopplø-selige ikke-kalsium-metafosfater, slik som natrium-metafosfat. Blandinger av slipemidler kan også brukes. I hvert tilfelle kan den totale mengde av slipemidler i tannpleiemidler etter nærværende oppfinnelse være fra 0,5 til 95 vekts-% av tannpleiemidlet.. Fortrinnsvis inneholder tannpasta fra 20 til 60 vekts-% slipemiddel. Slipemiddelpartikkelstorrelsen er fortrinnsvis fra 2 - 20 (j . Other suitable abrasives include aluminum oxide and the insoluble non-calcium metaphosphates, such as sodium metaphosphate. Mixtures of abrasives can also be used. In each case, the total quantity of abrasives in dental care products according to the present invention can be from 0.5 to 95% by weight of the dental care product. Preferably, toothpaste contains from 20 to 60% by weight of abrasives. The abrasive particle size is preferably from 2 - 20 (j .
Egnede skummemidler er de som er rimelig stabile og danner skum over et utstrakt pH-område, fortrinnsvis anioniske organiske syntetiske rensemidler. Eksempler på slike midler er vannopploselige salter av alkylsulfat som har fra 10 til 18 karbonatomer i alkylradikalet, slik som natriumlaurylsulfat, vannopploselige salter av sulfonerte monoglycerider av fettsyrer med 10 til 18 karbonatomer, slik som natrium-monoglyceridsul-fonat, salter av C-^Q - C^g fettsyreamider av taurin, slik som natrium-N-mety 1-N-palmitoy 1-taurid, salter av - C-^g fett-syreestere av isetionsyre, og i det vesentlige mette-de ali-fatiske acylamider av mettede monoaminokarboksylsyrer med fra 2 til 6 karbonatomer og i hvilke acylradikalet inneholder 12 Suitable foaming agents are those which are reasonably stable and form foam over a wide pH range, preferably anionic organic synthetic cleaning agents. Examples of such agents are water-soluble salts of alkyl sulfate having from 10 to 18 carbon atoms in the alkyl radical, such as sodium lauryl sulfate, water-soluble salts of sulfonated monoglycerides of fatty acids with 10 to 18 carbon atoms, such as sodium monoglyceride sulfonate, salts of C-^Q - C^g fatty acid amides of taurine, such as sodium-N-methyl 1-N-palmitoy 1-tauride, salts of - C-^g fatty acid esters of isethionic acid, and essentially saturated aliphatic acylamides of saturated monoaminocarboxylic acids with from 2 to 6 carbon atoms and in which the acyl radical contains 12
til 16 karbonatomer, slik som natrium-N-lauroylsarcosid. Blandinger av to eller flere skummemidler kan brukes. to 16 carbon atoms, such as sodium N-lauroyl sarcoside. Mixtures of two or more foaming agents can be used.
Skummemidlet kan være til stede i tannpleiemidlene ettet nærværende oppfinnelse i en mengde fra 0,5 til 5 vekts-% av det totale middel. The foaming agent can be present in the dentifrices according to the present invention in an amount from 0.5 to 5% by weight of the total agent.
Ved fremstilling av tannpasta er det nodvendig å tilsette et fortykningsmateriale for å gi en onsket konsistens. Foretrukne fortykningsmidler er hydroksyetylcellulose og vannopploselige salter av celluloseetere, slik som natrium-karboksymety1-cellu-lose og natrium-karboksymety1-hydroksy-etyl-cellulose. Naturlige gummier, slik som karayagummi, arabisk gummi og tragacant-gummi kan også brukes. Kolloidalt magnesium-aluminiumsilikat eller, finfordelt silica kan brukes som del av fortykningsmidler i en mengde på fra 0,5 til 5,0 vekts-% av den totale blanding kan brukes. When making toothpaste, it is necessary to add a thickening material to give the desired consistency. Preferred thickeners are hydroxyethyl cellulose and water-soluble salts of cellulose ethers, such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose. Natural gums such as gum karaya, gum arabic and gum tragacanth can also be used. Colloidal magnesium aluminum silicate or finely divided silica can be used as part of thickening agents in an amount of from 0.5 to 5.0% by weight of the total mixture can be used.
Det er også onskelig å inkludere et fuktemiddel i en tannpasta for å forhindre herdning. Egnede fuktemidler omfatter glyserin, It is also desirable to include a humectant in a toothpaste to prevent hardening. Suitable humectants include glycerin,
sorbitol og andre spisbare flerverdige alkoholer. Fukte- sorbitol and other edible polyhydric alcohols. Moisturize
midlet kan utgjore opptil ca 36 vekts-% av tannpastablandingen. the agent can make up to about 36% by weight of the toothpaste mixture.
Egnede smaksmidler omfatter vintergrommolje, peppermynteolje, olje av gronn myrte, sassafrasolje og krydderolje. Sotningsmidler som kan anvendes inkluderer sakkarin, dekstrose, levulose og natriumcyklamat. Suitable flavoring agents include oil of wintergreen, peppermint oil, oil of green myrtle, sassafras oil and clove oil. Blackening agents that can be used include saccharin, dextrose, levulose and sodium cyclamate.
Flere representative munnpleiemidler som illustrerer nærværende oppfinnelse angis i de folgende eksempler. Several representative oral care products that illustrate the present invention are given in the following examples.
EKSEMPEL I EXAMPLE I
En tannpasta med folgende blandinger ble fremstilt ved konven-sjonelle metoder: A toothpaste with the following mixtures was prepared by conventional methods:
Denne blanding hemmer effektivt tannstensdannelse på tannemaljen og når den ble undersokt ved en kontinuerlig neddykningsprove som beskrevet her, ble ingen avkalkning bemerket etter 7 dagers, prove. This composition effectively inhibits calculus formation on tooth enamel and when tested by a continuous immersion test as described herein, no decalcification was noted after the 7 day test.
EKSEMPEL II EXAMPLE II
En tannpasta ble fremstilt som var identisk i sammensetning til tannpastaen etter eksempel I, borsett fra at 3,0 deler i stedet for 1,5 deler dinatrium-dihydrogen-etan-l-hydroksy-1,1-difosfonat og 30,08 deler i stedet for 31,58 deler vann ble brukt. Denne blanding ble også funnet å være effektiv og forårsaket ingen skade på tannemaljen etter 7 dagers behandling. A toothpaste was prepared which was identical in composition to the toothpaste according to Example I, except that 3.0 parts instead of 1.5 parts disodium dihydrogen ethane-1-hydroxy-1,1-diphosphonate and 30.08 parts in instead of 31.58 parts of water was used. This mixture was also found to be effective and caused no damage to tooth enamel after 7 days of treatment.
Dinatriumdihydrogensaltet av etan-l-hydroksy-1,1-difosfonsyre i forannevnte tannpasta kan erstattes med etan-l-hydroksy-1,1-difosfonsyre eller kalium, ammonium eller substituerte ammonium-salter av disse med i det vesentlige ekvivalente resultater. The disodium dihydrogen salt of ethane-1-hydroxy-1,1-diphosphonic acid in the aforementioned toothpaste can be replaced with ethane-1-hydroxy-1,1-diphosphonic acid or potassium, ammonium or substituted ammonium salts thereof with essentially equivalent results.
EKSEMPEL III EXAMPLE III
En annen tannpasta ble fremstilt med folgende sammensetning: Another toothpaste was produced with the following composition:
Når brukt på vanlig måte hemmer denne tannpasta dannelsen av tannsten og ingen avkalkning på tannemaljen ble iakttatt■etter 7 dagers prove. When used in the usual way, this toothpaste inhibits the formation of tartar and no decalcification of the tooth enamel was observed after a 7-day trial.
EKSEMPEL IV EXAMPLE IV
En tannpasta som inneholder 3 deler dinatrium-dihydrogen-etan-1-hydroKsy-l,1-difosfonat og 38,08 deler vann, men ellers identisk med tannpastaen etter eksempel III ble fremstilt. Denne pasta ble funnet å være effektiv og forårsaket ingen iakt-tagbar avkalkning av tannemaljen etter 7 dagers prove. A toothpaste containing 3 parts of disodium dihydrogen-ethane-1-hydroxy-1,1-diphosphonate and 38.08 parts of water, but otherwise identical to the toothpaste according to example III was prepared. This paste was found to be effective and caused no observable decalcification of tooth enamel after 7 days of testing.
Dinatrium-dihydrogensaltet av etan-l-hydroksy-1,1-difosfonsyre som brukes i dette eksempel kan erstattes med dikalium-dihydro-gen-etan-l-hydroksy-1,1-difosfonat, diammonium-dihydrogen-etan-1-hydroksy-l,1-difosfonat eller bis(trietanolammonium)-dihydro-gen-etan-l-hydroksy-1,1-difosfonat med ekvivalente resultater. The disodium dihydrogen salt of ethane-1-hydroxy-1,1-diphosphonic acid used in this example can be replaced by dipotassium dihydrogen-ethane-1-hydroxy-1,1-diphosphonate, diammonium dihydrogen-ethane-1-hydroxy -1,1-diphosphonate or bis(triethanolammonium)-dihydro-gen-ethane-1-hydroxy-1,1-diphosphonate with equivalent results.
Flere munnvannblandinger ble fremstilt i overensstemmelse med nærværende oppfinnelse som folger: Several mouthwash compositions were prepared in accordance with the present invention as follows:
Når brukt på samme måte som konvensonelt munnvann, minst en gang daglig, reduserer hver av ovennevnte munnvann materielt akkumulasjon av kalk på overflaten av tennene. Ingen avkalkning ble observert etter 7 dagers prove på tannemalje ved bruk av disse munnvann. When used in the same manner as conventional mouthwashes, at least once daily, each of the above mouthwashes materially reduces the accumulation of limescale on the surface of the teeth. No decalcification was observed after 7 days of testing on tooth enamel using these mouthwashes.
EKSEMPEL IX EXAMPLE IX
En tyggegummi i overensstemmelse med nærværende oppfinnelse ble sammensatt som folger: A chewing gum in accordance with the present invention was composed as follows:
Denne sammensetning gir et effektivt middel for å hemme tannstendannelse uten å skade tannstrukturen når det tygges regu-lært på vanlig måte. This composition provides an effective means of inhibiting calculus formation without damaging the tooth structure when chewing regularly in the usual way.
EKESMPEL X EXAMPLE X
En profylatisk pasta for bruk av tannlegen for fjerning av flekker og polere tennene etter mekanisk fjerning av tannsten-avsetning sammensettes som folger: A prophylactic paste for use by the dentist to remove stains and polish the teeth after mechanical removal of tartar deposits is composed as follows:
Når påfort på tennene ved hjelp av en profylatisk gummikopp på vanlig måte, hemmer denne pasta at nye tannstensavsetninger utvikler seg. When applied to the teeth using a prophylactic rubber cup in the usual way, this paste inhibits the development of new tartar deposits.
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK561184A DK163842C (en) | 1984-11-27 | 1984-11-27 | PROGRAMMABLE ELECTRICAL WATCH |
| PCT/DK1985/000110 WO1986003308A1 (en) | 1984-11-27 | 1985-11-26 | A programmable timer |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| NO863055D0 NO863055D0 (en) | 1986-07-28 |
| NO863055L NO863055L (en) | 1986-07-28 |
| NO165897B true NO165897B (en) | 1991-01-14 |
| NO165897C NO165897C (en) | 1991-04-24 |
Family
ID=8143930
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO863055A NO165897C (en) | 1984-11-27 | 1986-07-28 | PROGRAMMABLE CLUTCH CLOCK. |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0207098B1 (en) |
| AU (1) | AU5192286A (en) |
| DE (1) | DE3577758D1 (en) |
| DK (1) | DK163842C (en) |
| FI (1) | FI87403C (en) |
| NO (1) | NO165897C (en) |
| WO (1) | WO1986003308A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3668508D1 (en) * | 1985-04-03 | 1990-03-01 | Siemens Ag | OPERATING UNIT FOR A TIMER. |
| DE4210874C2 (en) * | 1992-04-01 | 1997-04-10 | Legrand Gmbh | Electronic timer |
| JPH06217219A (en) * | 1993-01-14 | 1994-08-05 | Toshiba Corp | Time diplay device |
| CH685179A5 (en) * | 1993-05-07 | 1995-04-13 | Landis & Gry Tech Innovat Ag | Operating means for a device for regulating and / or controlling a temperature. |
| FR2746300B1 (en) * | 1996-03-21 | 1998-08-07 | Theramex | NEW DEVICE FOR PROGRAMMING AND OBSERVING MEDICINAL TREATMENT AND USES THEREOF |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2019041B (en) * | 1978-04-03 | 1982-07-28 | Horstmann Gear Group Ltd | Programmable timer |
| FR2461972A1 (en) * | 1979-07-18 | 1981-02-06 | Vedette Horlogerie | HOUR-RESET SWITCH WITH MICROCALCULATOR OR MICROPROCESSOR |
| DE3214372A1 (en) * | 1982-04-20 | 1983-11-03 | Westdeutsche Elektrogerätebau GmbH, 4770 Soest | ELECTRONIC TIMER |
| DE3310344A1 (en) * | 1983-03-22 | 1984-10-04 | Viessmann Werke Kg, 3559 Allendorf | DIGITAL TIMER |
-
1984
- 1984-11-27 DK DK561184A patent/DK163842C/en not_active IP Right Cessation
-
1985
- 1985-11-26 AU AU51922/86A patent/AU5192286A/en not_active Abandoned
- 1985-11-26 EP EP85906045A patent/EP0207098B1/en not_active Expired - Lifetime
- 1985-11-26 DE DE8585906045T patent/DE3577758D1/en not_active Expired - Lifetime
- 1985-11-26 WO PCT/DK1985/000110 patent/WO1986003308A1/en active IP Right Grant
-
1986
- 1986-07-18 FI FI862986A patent/FI87403C/en not_active IP Right Cessation
- 1986-07-28 NO NO863055A patent/NO165897C/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI862986A0 (en) | 1986-07-18 |
| WO1986003308A1 (en) | 1986-06-05 |
| EP0207098B1 (en) | 1990-05-16 |
| FI87403C (en) | 1992-12-28 |
| NO165897C (en) | 1991-04-24 |
| NO863055D0 (en) | 1986-07-28 |
| NO863055L (en) | 1986-07-28 |
| DK561184A (en) | 1986-05-28 |
| EP0207098A1 (en) | 1987-01-07 |
| DK163842C (en) | 1992-08-24 |
| DK561184D0 (en) | 1984-11-27 |
| AU5192286A (en) | 1986-06-18 |
| DK163842B (en) | 1992-04-06 |
| DE3577758D1 (en) | 1990-06-21 |
| FI862986A (en) | 1986-07-18 |
| FI87403B (en) | 1992-09-15 |
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